The Human TREX-2 Complex Interacts with Subunits of the ORC Complex

Dokl Biochem Biophys. 2023 Dec;513(1):346-349. doi: 10.1134/S1607672923700552. Epub 2023 Dec 8.

Abstract

The TREX-2 protein complex is the key complex involved in the export of mRNA from the nucleus to the cytoplasm through the nuclear pores. Previously, a joint protein complex of TREX-2 with ORC was isolated in D. melanogaster. It was shown that the interaction of TREX-2 with ORC is necessary for efficient mRNA export from the nucleus to the cytoplasm. In this work, we showed that the TREX-2-ORC joint complex is also formed in human cells.

Keywords: GANP; ORC; Orc3; Orc4; PCID2; TREX-2; Xmas-2; mRNA export.

MeSH terms

  • Active Transport, Cell Nucleus
  • Animals
  • Cell Nucleus / genetics
  • Cell Nucleus / metabolism
  • Drosophila melanogaster* / metabolism
  • Humans
  • Nuclear Proteins* / metabolism
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism

Substances

  • Nuclear Proteins
  • RNA, Messenger
  • TREX2 protein, human