Tag, you're it: G-ICAT identifies p120-cysteine glutathionylation triggering E-cadherin destabilization

Kevin T Fridianto; Yimon Aye

doi:10.1016/j.chembiol.2023.11.012

Tag, you're it: G-ICAT identifies p120-cysteine glutathionylation triggering E-cadherin destabilization

Cell Chem Biol. 2023 Dec 21;30(12):1501-1504. doi: 10.1016/j.chembiol.2023.11.012.

Authors

Kevin T Fridianto¹, Yimon Aye²

Affiliations

¹ Swiss Federal Institute of Technology Lausanne, Lausanne, Switzerland.
² Swiss Federal Institute of Technology Lausanne, Lausanne, Switzerland. Electronic address: yimon.aye@epfl.ch.

PMID: 38134879
DOI: 10.1016/j.chembiol.2023.11.012

Abstract

Current methods have limited ability in directly quantifying the extent of glutathionylation on specific protein-cysteines. In this issue of Cell Chemical Biology, Ahn et al.¹ report G-ICAT (glutathione-based isotope-coded affinity tag), aimed at addressing this limitation. G-ICAT identifies Cysteine-692 within p120-catenin-a member of cadherin complex essential for cell-cell-contact maintenance-where C692-specific glutathionylation promotes E-cadherin destabilization.

Publication types

Comment

MeSH terms

Cadherins*
Cysteine*

Substances

Cysteine
Cadherins