Botanical extract combined with minoxidil improve hidrotic ectodermal dysplasia caused by p.G11R mutations: a case report

J Dermatolog Treat. 2024 Dec;35(1):2378163. doi: 10.1080/09546634.2024.2378163. Epub 2024 Jul 11.

Abstract

Purpose: We aim to explore a potential treatment strategy for hair loss.

Materials and methods: A male 6-year-old child was diagnosed with hidrotic ectodermal dysplasia 2 (HED2) caused by GJB6 (p.G11R) mutations. He presented at our clinic with diffuse thinning and fine and brittle hair since birth. Additionally, the child exhibited abnormal development of teeth, fingernails, and toenails. The condition of the child's hair had not improved significantly with age. He was treated with botanical extracts combined with Minoxidil.

Results: After one and a half months of treatment, the patient showed remarkable hair growth.

Conclusions: Our team has previously used botanical extracts in combination for the treatment of autosomal recessive wooly hair in children. In the present case, treatment with botanical extract combined with minoxidil was found to be equally efficacious. This case report provides valuable information for future studies on the use of botanical extracts in treating hair loss, as well as a safe and effective potential treatment strategy for children with congenital alopecia.

Keywords: Clouston syndrome; Hidrotic ectodermal dysplasia; botanical extracts; case report; congenital alopecia.

Publication types

  • Case Reports

MeSH terms

  • Alopecia* / drug therapy
  • Alopecia* / pathology
  • Child
  • Connexins / genetics
  • Drug Therapy, Combination
  • Ectodermal Dysplasia* / drug therapy
  • Ectodermal Dysplasia* / genetics
  • Ectodermal Dysplasia* / pathology
  • Humans
  • Male
  • Minoxidil*
  • Mutation
  • Plant Extracts* / administration & dosage
  • Treatment Outcome

Substances

  • Minoxidil
  • Plant Extracts
  • Connexins