Screening for malignant hyperpyrexia

Br Med J. 1972 Sep 2;3(5826):559-61. doi: 10.1136/bmj.3.5826.559.

Abstract

The methods used to screen patients for malignant hyperpyrexia at present are not sufficiently accurate. This paper reports more specific methods of detecting patients liable to develop malignant hyperpyrexia. A motor-point muscle biopsy is performed for histopathological examination and to detect muscle contracture in vitro after exposure to halothane and suxamethonium.

MeSH terms

  • Acidosis
  • Adolescent
  • Adult
  • Anesthesia, General / adverse effects*
  • Biopsy
  • Child
  • Child, Preschool
  • Creatine Kinase / blood
  • Female
  • Fructose-Bisphosphate Aldolase / blood
  • Halothane / pharmacology
  • Humans
  • Male
  • Malignant Hyperthermia / diagnosis*
  • Mass Screening*
  • Methods
  • Microscopy, Electron
  • Middle Aged
  • Muscle Contraction / drug effects
  • Neuromuscular Junction / drug effects
  • Neuromuscular Junction / pathology
  • Succinylcholine / pharmacology

Substances

  • Creatine Kinase
  • Fructose-Bisphosphate Aldolase
  • Succinylcholine
  • Halothane