Abstract
The methods used to screen patients for malignant hyperpyrexia at present are not sufficiently accurate. This paper reports more specific methods of detecting patients liable to develop malignant hyperpyrexia. A motor-point muscle biopsy is performed for histopathological examination and to detect muscle contracture in vitro after exposure to halothane and suxamethonium.
MeSH terms
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Acidosis
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Adolescent
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Adult
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Anesthesia, General / adverse effects*
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Biopsy
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Child
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Child, Preschool
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Creatine Kinase / blood
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Female
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Fructose-Bisphosphate Aldolase / blood
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Halothane / pharmacology
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Humans
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Male
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Malignant Hyperthermia / diagnosis*
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Mass Screening*
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Methods
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Microscopy, Electron
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Middle Aged
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Muscle Contraction / drug effects
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Neuromuscular Junction / drug effects
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Neuromuscular Junction / pathology
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Succinylcholine / pharmacology
Substances
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Creatine Kinase
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Fructose-Bisphosphate Aldolase
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Succinylcholine
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Halothane