Abstract
Sixteen cases of osteosclerotic myeloma and peripheral neuropathy (SM-PN) were reviewed. The neuropathy resembled chronic inflammatory-demyelinating polyneuropathy with predominantly motor disability, high CSF protein levels, and low motor nerve conduction velocities. Twelve of the 16 patients had detectable levels of monoclonal serum proteins, all with lambda light chains, but results of other laboratory studies were usually normal. Most of the patients also had organomegaly, endocrine abnormalities, or both. Treatment of solitary lesions with tumoricidal irradiation usually improved the neuropathy and reversed the nonneurologic abnormalities; chemotherapy for multiple osteosclerotic lesions was less helpful.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Aged
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Antibodies, Monoclonal / immunology
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Bone Neoplasms / complications
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Bone Neoplasms / diagnosis*
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Bone Neoplasms / drug therapy
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Female
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Humans
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Immunoglobulin kappa-Chains
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Male
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Melphalan / therapeutic use
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Middle Aged
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Multiple Myeloma / complications
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Multiple Myeloma / diagnosis*
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Multiple Myeloma / drug therapy
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Osteosclerosis / complications
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Osteosclerosis / diagnosis
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Osteosclerosis / drug therapy
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Peripheral Nervous System Diseases / complications
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Peripheral Nervous System Diseases / diagnosis*
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Peripheral Nervous System Diseases / drug therapy
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Peripheral Nervous System Diseases / immunology
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Prednisone / therapeutic use
Substances
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Antibodies, Monoclonal
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Immunoglobulin kappa-Chains
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Melphalan
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Prednisone