Gonadal and extragonadal germ cell neoplasia of childhood

Hum Pathol. 1983 Jun;14(6):493-511. doi: 10.1016/s0046-8177(83)80004-5.

Abstract

Germ cell tumors in children are characterized by diverse clinical, pathologic, and prognostic features. For this reason, it is difficult to generalize about the behavior of these tumors; cases must be evaluated individually, with consideration for the age of the patient at diagnosis, the anatomic site of the tumor, and its histologic appearance. Experimental models and cytogenetic studies of teratomatous development have contributed to our basic understanding of the biology of differentiation and tumorigenesis.

Publication types

  • Review

MeSH terms

  • Abdominal Neoplasms / pathology
  • Adolescent
  • Animals
  • Cell Transformation, Neoplastic / pathology
  • Child
  • Child, Preschool
  • Choriocarcinoma / pathology
  • Dysgerminoma / classification
  • Dysgerminoma / epidemiology
  • Dysgerminoma / pathology*
  • Female
  • Head and Neck Neoplasms / pathology
  • Humans
  • Infant, Newborn
  • Male
  • Mesonephroma / pathology
  • Mice
  • Ovarian Neoplasms / classification
  • Ovarian Neoplasms / epidemiology
  • Ovarian Neoplasms / pathology*
  • Pregnancy
  • Sacrococcygeal Region
  • Teratoma / classification
  • Teratoma / epidemiology
  • Teratoma / pathology*
  • Testicular Neoplasms / classification
  • Testicular Neoplasms / epidemiology
  • Testicular Neoplasms / pathology*
  • Thoracic Neoplasms / pathology
  • United States
  • Uterine Neoplasms / pathology