Biochemical aspects of tuftsin deficiency syndrome

Med Biol. 1981 Jun;59(3):134-8.

Abstract

From work reported so far it is possible to draw certain conclusions namely, that Tuftsin, Thr-Lys-Pro-Arg, is a biologically functional entity. The presence of congenital familial deficiency reinforces this conclusion. The fact that these patients suffer from repeated infections points at an in vivo system that parallels the in vitro studies showing tuftsin stimulation of the phagocytic activity of the tissue macrophage and blood granulocyte. Such stimulation occurs at hormonal concentrations; (half maximal at 100 M). Furthermore, tuftsin enchances pinocytosis, as it does phagocytosis, only in phagocytic cells. It stimulates the motility of these cells as well as their longevity. Tuftsin stimulates the hexosemonophosphate shunt and, presumably through the formation of active oxygen-derived compounds, augments the bactericidal as well as the tumoricidal activity of the macrophage. There are highly specific receptors on the cell membrane of phagocytic cells. The structure of tuftsin cannot be altered without producing inactive and/or inhibitory analogs, an exception being the interchange of lysine and arginine. The release of tuftsin from carrier leukokinin requires two enzymes, one of which is on the outer membrane of the phagocyte and the other in the spleen. The absence of the latter explains the deficiency observed after the abrogation of splenic function for whatever cause.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Bacteria / immunology
  • Humans
  • Immunoglobulin Fragments* / immunology
  • Immunologic Deficiency Syndromes / genetics
  • Immunologic Deficiency Syndromes / immunology*
  • Macrophage Activation
  • Macrophages / immunology
  • Mice
  • Neoplasms, Experimental / immunology
  • Phagocytosis
  • Tuftsin* / immunology

Substances

  • Immunoglobulin Fragments
  • Tuftsin