Myelofibrosis with complex chromosome abnormality in a patient with erythrocytosis due to hemoglobin Rainier and treated with 32P

Am J Hematol. 1978;5(1):63-9. doi: 10.1002/ajh.2830050109.

Abstract

A patient with familial erythrocytosis associated with Hemoglobin Rainier, and previously treated with 32P, developed myelofibrosis with a hyperdiploid chromosome clone in the myeloid cells (51,XX,+1,2q-(q33),+6,+9,+11,-19,+20q+,+mar 1.) This transformation from a benign disorder of differentiated erythrocytes to a malignant disorder may have been secondary to radiophosphorus therapy.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chromosome Aberrations / blood*
  • Chromosome Disorders
  • Female
  • Hemoglobins, Abnormal*
  • Humans
  • Karyotyping
  • Middle Aged
  • Phosphorus Radioisotopes / therapeutic use*
  • Polycythemia / blood
  • Polycythemia / complications*
  • Polycythemia / genetics
  • Polycythemia / therapy
  • Primary Myelofibrosis / blood
  • Primary Myelofibrosis / complications*
  • Primary Myelofibrosis / genetics
  • Washington

Substances

  • Hemoglobins, Abnormal
  • Phosphorus Radioisotopes