Abstract
The Wilms' tumor gene WT1 functions as a tumor suppressor gene, repressing transcription of several growth factors and growth factor receptors. The bcl-2 and c-myc proto-oncogenes are essential for regulation of apoptosis and cell proliferation with roles in development and oncogenesis. We found that WT1 can repress transcription of both the bcl-2 and c-myc promoters. This suggests that WT1 regulates bcl-2 and c-myc during renal development, and the loss of functional WT1 results in deregulation of bcl-2 and c-myc, contributing to tumor formation.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Base Sequence
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DNA-Binding Proteins / genetics*
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Gene Expression Regulation*
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Genes, Tumor Suppressor*
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Genes, myc*
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Humans
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Kidney Neoplasms / genetics*
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Molecular Sequence Data
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Promoter Regions, Genetic
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Proto-Oncogene Proteins / genetics*
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Proto-Oncogene Proteins c-bcl-2
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Proto-Oncogenes*
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Transcription Factors / genetics*
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WT1 Proteins
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Wilms Tumor / genetics*
Substances
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DNA-Binding Proteins
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Proto-Oncogene Proteins
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Proto-Oncogene Proteins c-bcl-2
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Transcription Factors
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WT1 Proteins