Abstract
We have isolated a human cDNA encoding a protein of 334 amino acids that shows 96% identity in amino acid sequence to murine cytosolic malate dehydrogenase. Heart and skeletal muscle expressed this gene most highly among the adult human tissues examined by Northern blot analysis. By fluorescence in situ hybridization, we determined its chromosomal location to be 2p15.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Amino Acid Sequence
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Animals
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Chromosome Banding
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Chromosome Mapping*
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Chromosomes, Human, Pair 2 / genetics
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Chromosomes, Human, Pair 2 / ultrastructure
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Cloning, Molecular
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Cytosol / enzymology
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DNA, Complementary / genetics*
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Humans
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In Situ Hybridization, Fluorescence
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Malate Dehydrogenase / genetics*
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Mice
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Molecular Sequence Data
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Muscle, Skeletal / enzymology
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Myocardium / enzymology
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Sequence Homology, Amino Acid
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Swine
Substances
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DNA, Complementary
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Malate Dehydrogenase