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Year | Number of Results |
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Page 1
The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis.
J Biol Chem. 1997 Mar 7;272(10):6097-100. doi: 10.1074/jbc.272.10.6097.
J Biol Chem. 1997.
PMID: 9045618
Free article.
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling.
Inoki K, Li Y, Zhu T, Wu J, Guan KL.
Inoki K, et al.
Nat Cell Biol. 2002 Sep;4(9):648-57. doi: 10.1038/ncb839.
Nat Cell Biol. 2002.
PMID: 12172553
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Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner.
Castro AF, Rebhun JF, Clark GJ, Quilliam LA.
Castro AF, et al.
J Biol Chem. 2003 Aug 29;278(35):32493-6. doi: 10.1074/jbc.C300226200. Epub 2003 Jul 3.
J Biol Chem. 2003.
PMID: 12842888
Free article.
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Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb.
Tee AR, Manning BD, Roux PP, Cantley LC, Blenis J.
Tee AR, et al.
Curr Biol. 2003 Aug 5;13(15):1259-68. doi: 10.1016/s0960-9822(03)00506-2.
Curr Biol. 2003.
PMID: 12906785
Free article.
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An autoinhibited noncanonical mechanism of GTP hydrolysis by Rheb maintains mTORC1 homeostasis.
Mazhab-Jafari MT, Marshall CB, Ishiyama N, Ho J, Di Palma V, Stambolic V, Ikura M.
Mazhab-Jafari MT, et al.
Structure. 2012 Sep 5;20(9):1528-39. doi: 10.1016/j.str.2012.06.013. Epub 2012 Jul 19.
Structure. 2012.
PMID: 22819219
Free article.
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Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome.
Menon S, Dibble CC, Talbott G, Hoxhaj G, Valvezan AJ, Takahashi H, Cantley LC, Manning BD.
Menon S, et al.
Cell. 2014 Feb 13;156(4):771-85. doi: 10.1016/j.cell.2013.11.049.
Cell. 2014.
PMID: 24529379
Free PMC article.
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Structural insights into TSC complex assembly and GAP activity on Rheb.
Yang H, Yu Z, Chen X, Li J, Li N, Cheng J, Gao N, Yuan HX, Ye D, Guan KL, Xu Y.
Yang H, et al.
Nat Commun. 2021 Jan 12;12(1):339. doi: 10.1038/s41467-020-20522-4.
Nat Commun. 2021.
PMID: 33436626
Free PMC article.
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