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38347000,38231539,38036052,37522970,37490874,37477779,36698167,36648607,36335114,36331687,36084573,35970994,35931675,35887382,35784559,35749888,35460500,35362533,35325324,35300993,34915523,34092618,33554951,33168159,33145961,33113547,32727431,32710851,32583001,32494007,32493414,32467349,32457113,32356191,32275863,32200486,32037650,31875653,31847392,31823290,31771180,31738383,31680140,31586944,31508890,31122679,31113820,30945690,30848790,30682326,30653502,30594023,30365147,30350263,30338346,30056117,30053089,29779108,29687007,29621572,29615365,29524179,29470850,29328495,29226546,29150385,28946136,28945762,28822014,28766847,28447314,28395282,28382840,28364785,28349238,28218468,27819360,27812134,27716204,27644646,27623941,27590586,27532210,27373487,27353258,27299695,27272834,27255663,27246621,27172746,26738606,26706833,26689622,26648141,26563994,26497996,26463630,26430715,26337161,26291053,26252249,26219921,26211576,26148588,26082409,26012212,25896444,25866162,25693948,25693802,25680198,25473182,25446090,25425114,25400749,25388513,25362932,25339573,25268741,25189651,25175038,25153223,25119174,25118293,25110710,25081930,25081697,25050889,25040157,24999547,24997432,24922664,24809702,24770843,24745653,24745618,24713135,24637962,24489919,24489728,24438088,24392142,24354797,24336871,24222252,24186206,24130778,23823800,23818948,23817810,23797814,23664098,23663564,23619944,23527719,23515613,23506534,23486542,23402816,23365645,23266446,23252569,23106397,23082760,22998174,22972910,22932330,22909219,22892600,22738321,22682017,22626974,22623732,22508822,22406993,22394253,22348393,22339909,22325222,22309212,22303694,22285568,22218435,22172258,22133293,22130793,22128190,22058336,22044563,22042973,22020329,21994939,21931726,21866554,21811077,21748295,21732141,21728395,21713359,21677874,21654344,21595894,21574055,21442237,21402719,21396585,21330319,21304894,21292299,21273178,21217522,21204214,21197570,21159245,21124078,21123183,21122407,21057462,20976540,20962017,20950153,20847162,20736806,20713879,20648549,20592355,20569071,20432247,20357178,20351332,20233590,20193554,20179633,20178321,20104520,20103837,20103656,20078550,20061696,19877134,19853071,19838209,19806209,19767315,19679045,19672856,19669768,19582762,19460140,19406106,19318572,19241236,19240157,19240156,19176870,19160858,18788919,18766208,18611244,18566589,18535748,18508432,18469701,18452152,18418709,18095062,18050122,17956902,17649826,17634559,17627944,17442315,17349528,17277889,17264177,17196841,17145858,16827799,16805964,16804965,16793764,16648580,16647191,16595699,16584539,16362313,16328478,16127155,16053920,16035620,16000560,15921396,15805544,15671548,15638375,15623623,15564321,15472208,15334055,15059221,14769130,14729630,14726697,14710368,14710366,14710354,14633695,14615489,14575710,14551153,12884909,12820418,12784091,12644306,12634644,12493743,12379772,12147227,12138114,12031683,12019176,11782378,11754068,11591350,11250706,10655455,9745438,9491374,9355755,8710868,8648195,8550552,8111378,3003744,2948220,2877871,1850606,1711844,1316909,37497005,37173768,37081542,36598389,36332473,36243800,36189799,36106406,36054916,35931997,35786404,35780715,35688943,35211808,35199365,35083738,35030978,34988853,34891198,34747545,34438446,34218203,34074726,33932050,33894267,33637620,33429867,33415003,33143702,33116033,32945416,32708730,32700452,32572901,32570949,32546241,32495406,32467173,32417396,32343508,32308049,32202300,32154665,32150843,32033461,32027876,31941753,31894289,31758670,31728045,31724454,31705876,31702994,31558604,31539124,31374070,31357837,31190579,31126198,31115568,30926641,30664191,30628637,30515804,30458886,30371738,30213860,30167815,30165429,30119887,30078228,30063751,29989645,29901181,29789409,29743626,29650947,29642855,29540831,29483580,29421153,29257334,29217764,29180608,29126188,29051069,28932920,28830678,28810236,28800315,28795385,28757207,28745651,28714005,28696156,28656297,28651495,28498434,28468775,28440508,28439706,28418902,28417283,28365890,28351623,28348046,28266043,28213921,28202495,28188432,28092675,28079144,28050756,28030849,27896672,27891760,27836546,27813495,27586516,27384680,27312358,27226530,27213344,27185872,27180807,27177336,27144430,27105537,27091859,27089502,27088794,27044882,26991004,26884344,26862994,26861122,26850678,26845446,26801096,26745129,26722410,26701791,26670433,26656446,26655273,26554308,26536657,26450156,26438154,26342551,26306402,26297545,26191333,26173023,26165226,26112748,26097570,26027733,26025408,25916750,25852271,25786252,25758790,25617986,25609710,25556445,25483727,25348345,25341922,25305490,25274331,25184138,25117070,25115504,25092925,25017244,24999188,24970814,24874051,24870578,24811788,24809298,24801045,24758241,24751329,24667580,24458568,24410957,24378652,24307738,24282274,24266654,24227890,24127040,24065146,24039995,24039934,24026884,24013232,23994953,23990442,23989734,23983239,23974362,23962053,23899556,23873272,23867124,23801064,23792093,23724116,23710710,23689439,23564324,23548939,23531874,23453369,23431408,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GWAS-identified hyperuricemia-associated IGF1R variant rs6598541 has a limited role in urate mediated inflammation in human mononuclear cells.

Gaal OI, Liu R, Marginean D, Badii M, Cabău G, Hotea I, Nica V, Colcear D; HINT Consortium; Pamfil C, Merriman TR, Rednic S, Popp RA, Crișan TO, Joosten LAB. Gaal OI, et al. Sci Rep. 2024 Feb 12;14(1):3565. doi: 10.1038/s41598-024-53209-7. Sci Rep. 2024. PMID: 38347000 Free PMC article.

Mapping respiratory syncytial virus fusion protein interactions with the receptor IGF1R and the impact of alanine-scanning mutagenesis on viral infection.

Hayes RS, Oraby AK, Camargo C, Marchant DJ, Sagan SM. Hayes RS, et al. J Gen Virol. 2024 Jan;105(1). doi: 10.1099/jgv.0.001951. J Gen Virol. 2024. PMID: 38231539

Insulin promotes growth in breast cancer cells through the type I IGF receptor in insulin receptor deficient cells.

Monteiro M, Zhang X, Yee D. Monteiro M, et al. Exp Cell Res. 2024 Jan 1;434(1):113862. doi: 10.1016/j.yexcr.2023.113862. Epub 2023 Nov 28. Exp Cell Res. 2024. PMID: 38036052 Free article.

Insulin-like growth factor 1 receptor inhibits the proliferation of acute myeloid leukaemia cells via NK cell activation.

Wang S, Wang X, Shen K, Wei C, Li J. Wang S, et al. Ann Hematol. 2023 Sep;102(9):2353-2364. doi: 10.1007/s00277-023-05378-0. Epub 2023 Jul 31. Ann Hematol. 2023. PMID: 37522970

Insulin-like growth factor-1 receptor crosstalk with integrins, cadherins, and the tumor microenvironment: sticking points in understanding IGF1R function in cancer.

Galifi CA, Wood TL. Galifi CA, et al. Endocr Relat Cancer. 2023 Aug 25;30(10):e230031. doi: 10.1530/ERC-23-0031. Print 2023 Oct 1. Endocr Relat Cancer. 2023. PMID: 37490874 Review.

Association of IGF1R polymorphisms with kidney function-related traits.

Park S, Jin HS. Park S, et al. Genes Genomics. 2023 Dec;45(12):1509-1515. doi: 10.1007/s13258-023-01430-5. Epub 2023 Jul 21. Genes Genomics. 2023. PMID: 37477779

IGF-1R down regulates the sensitivity of hepatocellular carcinoma to sorafenib through the PI3K / akt and RAS / raf / ERK signaling pathways.

Cai W, Ma Y, Song L, Cao N, Gao J, Zhou S, Tang X. Cai W, et al. BMC Cancer. 2023 Jan 25;23(1):87. doi: 10.1186/s12885-023-10561-7. BMC Cancer. 2023. PMID: 36698167 Free PMC article.

LINC02381 suppresses cell proliferation and promotes apoptosis via attenuating IGF1R/PI3K/AKT signaling pathway in breast cancer.

Golestan S, Soltani BM, Jafarzadeh M, Ghaemi Z, Nafisi N. Golestan S, et al. Funct Integr Genomics. 2023 Jan 17;23(1):40. doi: 10.1007/s10142-023-00965-w. Funct Integr Genomics. 2023. PMID: 36648607

Interaction of a viral insulin-like peptide with the IGF-1 receptor produces a natural antagonist.

Moreau F, Kirk NS, Zhang F, Gelfanov V, List EO, Chrudinová M, Venugopal H, Lawrence MC, Jimenez V, Bosch F, Kopchick JJ, DiMarchi RD, Altindis E, Kahn CR. Moreau F, et al. Nat Commun. 2022 Nov 5;13(1):6700. doi: 10.1038/s41467-022-34391-6. Nat Commun. 2022. PMID: 36335114 Free PMC article.

A common IGF1R gene variant predicts later life breast cancer risk in women with preeclampsia.

Powell M, Fuller S, Gunderson E, Benz C. Powell M, et al. Breast Cancer Res Treat. 2023 Jan;197(1):149-159. doi: 10.1007/s10549-022-06789-9. Epub 2022 Nov 4. Breast Cancer Res Treat. 2023. PMID: 36331687 Free PMC article.

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