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37787490,37344639,36927384,34757127,32358589,32224526,32123303,31285551,31163979,31145547,31071411,30204961,30106602,29484414,29271604,28777121,27841865,27810072,27753652,27670374,27273450,26981887,25755752,25706034,24427333,23737487,22907845,22738312,22464151,22447278,22389993,22225925,22131876,22081024,22020327,21779496,21207082,20868603,20688353,20372086,20234004,19825990,19737955,19363522,19298812,19037990,18316782,17614099,17572489,17243098,17064357,16909118,16883571,16707572,16649144,16465392,16405965,16332724,16266749,15943972,15899852,15711535,15662129,15591313,15451031,15122343,15041731,14623285,12865432,12851216,12691824,12626521,12490852,12429936,12127063,12010819,11756411,11751906,10497893,8710867,8349614,7477354,3616625,3003687,2993863,2955285,1846778,1612588,37399073,37258577,36564468,35948545,34625747,34356620,32678071,32591521,32506814,32414921,31941156,31541523,31521821,31469916,31017896,30586319,30303876,30281322,29917268,28677804,28586056,28466200,28000790,26646323,26466569,26295714,26100670,25817574,25684575,25473895,25355599,25265753,24863296,24777450,24330068,23760062,23680146,23610963,23517740,23360980,23087049,22922483,22833462,22262839,22110214,21881167,21617351,21577205,21139044,20802526,20071468,19953625,19895838,19881545,19812696,19638615,19595761,19357705,19164755,19049963,19047752,18952605,18794803,18472967,18356164,18294816,18273062,18241070,18182859,18073111,17998336,17603483,17428866,17332776,17277048,16964381,16916524,16862215,16537561,16504566,16364920,16214894,16172610,16029117,15845549,15710605,15674327,15666389,15470083,14688280,12843393,12663662,12551923,12488548,12374792,12360521,12244094,12237340,12087097,12079506,11733498,11604401,11447113,11427728,11325826,11306563,11171046,11005817,10887184,10585452,10373531,10064593,9671314,9624170,9315742,9234708,9230211,9153224,9115221,9099670,9001246,8962087,8939988,8911690,8910675,8816460,8756332,8692945,8601312,8530446,8408024,8332195,8321321,8035810,8002932,7939632,7882972,7791872,7766599,7760835,7730360,7628630,7559537,2475255,1639773,38136612,37066513,37020037,35422233,34153339,32956704,32862732,31612616,31430364,30795516,30762279,30610161,30488209,29048686,28806393,27901111,27363278,27153315,26649302,26513016,26048984,24969872,24486585,24108181,23934108,23352452,23157514,22926515,22886303,22886302,22752602,22556409,22421411,22350907,22138288,22096607,21215703,20854332,20679480,20404846,20230813,20133694,20080631,19710016,19638574,18465753,18064632,17699868,17635919,17409432,17097642,16924233,16757351,16575407,16413928,16086581,15935327,15925322,15705808,15657590,15459208,15211515,15035987,14688025,12717443,12391160,11997508,11971957,11948406,11853019,11585916,11350735,11044439,10869570,10576742,10557073,10531364,10454553,9867809,9819434,9733801,9710607,9632690,9553107,8876196,8753867,8663231,8332187,8085158,7969158,7935795,7744247,7517401,37170083,35475426,34688658,34526658,34184824,32778845,31024343,30368668,30276917,30140388,29970115,29722566,29402968,29242214,28743511,28445974,28174233,28146421,27703006,27368419,27167344,25674762,25155755,25137548,25027403,25022756,24929361,24223781,23923067,23153539,22711539,22605333,22438909,21871886,21808062,21536655,20543023,20389169,20364151,20301557,20179161,20178605,20130576,20052757,20039095,19917255,19696784,19492075,19122653,19020799,18708364,18641128,18592002,18483265,17397260,17229891,17018604,16837009,16537381,15653554,12954639,12925535,12379659,11909642,11784866,11676916,11409918,11231577,10887173,10523633,10498616,10369681,9823899,9446616,9261098,9091312,8929532,8887682,8628317,8621729,8394352,8393135,8349631,8063729,7731720,7527398,32719131,27391150,25862004,25713071,24746704,24167568,23327923,23118896,23076151,22935974,22826437,22282237,21831839,21478863,20947508,20489206,20212043,20141835,19801192,19718030,19197339,19063885,19029954,18715846,18556463,16569214,16330544,16322212,16009725,15520859,15385642,15314064,15067053,14654780,14597674,12861023,12682854,11226259,10958680,10757792,10611249,9150145,9069260,8670882,8307946,7862125,7782277,7479742,33513349,30481304,26004137,24371145,21892329,21122381,19633425,19222999,19011619,18022816,18006502,17889669,17666399,16803888,16573649,16565089,16335536,15664191,15075335,11741534,10882715,10848612,10837247,10329666,10205168,9765203,9523700,8929531,8084603,7644510,7523381,36038253,26721396,26519477,23509299,22510884,22169110,20302979,20086174,19802003,19206169,19133693,19001375,17462920,16301319,16156789,15752761,15618521,15215316,14724584,12774123,11585923,10922060,10620507,9689060,9564038,8900182,8157000,24292678,21917714,19058874,15886202,15485920,15150271,12975377,10969079,10433554,9808624,9311917,9154803,8702721,36279628,30595535,28537252,26973648,25512530,24736947,21457714,20630999,19385034,17603482,16239230,15866172,15849194,12194967,11969417,1611909,24008843,21336309,20179103,19380724,17889508,15192046,10783161,10644344,10486249,15936278,11697890,9488663,24462205,23554973,16364241,15854902,15031288,11788587,26578655,23559827,22222486,21514245,19805522,18332145,15688026,15118098,14724641,31015455,21419342,16093354,14654844,20301303,20159553,16041367,10712923,19667065,37045861,9144171,9069267,17724343,10523642,34407391,22103831,21348951,12734410,12620389,26627737,11520933,9658081,11463741,34017080,16306228,16611982,35379950,28162770,19608861,23397142,23105109,34831298,28205554,34591642,17979178,23891004,19730683,15778465,30442766,24658140,25402006,25476789,20686565,34299191,22678362,35687106,25640309,19953087,24097068,17314511,21048031,18660489,24189400,38496616,23383273,37931956,32235678,36168628,26549023,25036637,24778252,25241761,22939624,25852190,35044719,23455922,24255178,34709266,30194290,30639242,36538041,34591612,23602568,27025967,34857952,26871637,36931259,36736316,28675297,31753913,35446349,27684187,17353931,27173435,36244648,30833792,32877691,26972000,35439318,17081983,31980649,8125298,35563538,19913121,29117863,32814053,32707033,26673895,36114006,21988832,22658674,31091453,31586073,34079125,36215168,35271311,26496610,32296183,28514442,8889548,33961781,15489334,12477932,21873635[uid]

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688 results

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RAF1 mutation leading to hypertrophic cardiomyopathy in a Chinese family with a history of sudden cardiac death: A diagnostic insight into Noonan syndrome.

Zheng J, Peng L, Cheng R, Li Z, Xie J, Huang E, Cheng J, Zhao Q. Zheng J, et al. Mol Genet Genomic Med. 2024 Jan;12(1):e2290. doi: 10.1002/mgg3.2290. Epub 2023 Oct 3. Mol Genet Genomic Med. 2024. PMID: 37787490 Free PMC article.

Molecular and cellular evidence for the impact of a hypertrophic cardiomyopathy-associated RAF1 variant on the structure and function of contractile machinery in bioartificial cardiac tissues.

Nakhaei-Rad S, Haghighi F, Bazgir F, Dahlmann J, Busley AV, Buchholzer M, Kleemann K, Schänzer A, Borchardt A, Hahn A, Kötter S, Schanze D, Anand R, Funk F, Kronenbitter AV, Scheller J, Piekorz RP, Reichert AS, Volleth M, Wolf MJ, Cirstea IC, Gelb BD, Tartaglia M, Schmitt JP, Krüger M, Kutschka I, Cyganek L, Zenker M, Kensah G, Ahmadian MR. Nakhaei-Rad S, et al. Commun Biol. 2023 Jun 21;6(1):657. doi: 10.1038/s42003-023-05013-8. Commun Biol. 2023. PMID: 37344639 Free PMC article.

Molecular analyses of the C-terminal CRAF variants associated with cardiomyopathy reveal their opposing impacts on the active conformation of the kinase domain.

Nakhaei-Rad S, Janatifard F, Dvorsky R, Ahmadian MR, Housaindokht MR. Nakhaei-Rad S, et al. J Biomol Struct Dyn. 2023;41(24):15328-15338. doi: 10.1080/07391102.2023.2187221. Epub 2023 Mar 16. J Biomol Struct Dyn. 2023. PMID: 36927384

The GPCR-β-arrestin complex allosterically activates C-Raf by binding its amino terminus.

Zang Y, Kahsai AW, Pakharukova N, Huang LY, Lefkowitz RJ. Zang Y, et al. J Biol Chem. 2021 Dec;297(6):101369. doi: 10.1016/j.jbc.2021.101369. Epub 2021 Oct 30. J Biol Chem. 2021. PMID: 34757127 Free PMC article.

RAF1 rearrangements are common in pancreatic acinar cell carcinomas.

Prall OWJ, Nastevski V, Xu H, McEvoy CRE, Vissers JHA, Byrne DJ, Takano E, Yerneni S, Ellis S, Green T, Mitchell CA, Murray WK, Scott CL, Grimmond SM, Hofmann O, Papenfuss A, Kee D, Fellowes A, Brown IS, Miller G, Kumarasinghe MP, Perren A, Nahm CB, Mittal A, Samra J, Ahadi M, Fox SB, Chou A, Gill AJ. Prall OWJ, et al. Mod Pathol. 2020 Sep;33(9):1811-1821. doi: 10.1038/s41379-020-0545-9. Mod Pathol. 2020. PMID: 32358589 Free article.

Gene sequencing and expression of Raf-1 in lymphatic metastasis of hypopharyngeal carcinoma.

Li Y, Lu T, Hu G. Li Y, et al. Cancer Biomark. 2020;28(2):181-191. doi: 10.3233/CBM-191238. Cancer Biomark. 2020. PMID: 32224526

Melanomas with activating RAF1 fusions: clinical, histopathologic, and molecular profiles.

Williams EA, Shah N, Montesion M, Sharaf R, Pavlick DC, Sokol ES, Alexander BM, Venstrom JM, Elvin JA, Ross JS, Tse JY, Mochel MC. Williams EA, et al. Mod Pathol. 2020 Aug;33(8):1466-1474. doi: 10.1038/s41379-020-0510-7. Epub 2020 Mar 2. Mod Pathol. 2020. PMID: 32123303 Free PMC article.

CRAF mutations in lung cancer can be oncogenic and predict sensitivity to combined type II RAF and MEK inhibition.

Noeparast A, Giron P, Noor A, Bahadur Shahi R, De Brakeleer S, Eggermont C, Vandenplas H, Boeckx B, Lambrechts D, De Grève J, Teugels E. Noeparast A, et al. Oncogene. 2019 Aug;38(31):5933-5941. doi: 10.1038/s41388-019-0866-7. Epub 2019 Jul 8. Oncogene. 2019. PMID: 31285551 Free PMC article.

Inducible Pluripotent Stem Cell-Derived Cardiomyocytes Reveal Aberrant Extracellular Regulated Kinase 5 and Mitogen-Activated Protein Kinase Kinase 1/2 Signaling Concomitantly Promote Hypertrophic Cardiomyopathy in RAF1-Associated Noonan Syndrome.

Jaffré F, Miller CL, Schänzer A, Evans T, Roberts AE, Hahn A, Kontaridis MI. Jaffré F, et al. Circulation. 2019 Jul 16;140(3):207-224. doi: 10.1161/CIRCULATIONAHA.118.037227. Epub 2019 Jun 5. Circulation. 2019. PMID: 31163979 Free PMC article.

RAF1 variant in a patient with Noonan syndrome with multiple lentigines and craniosynostosis.

Rodríguez F, Ponce D, Berward FJ, Lopetegui B, Cassorla F, Aracena M. Rodríguez F, et al. Am J Med Genet A. 2019 Aug;179(8):1598-1602. doi: 10.1002/ajmg.a.61203. Epub 2019 May 30. Am J Med Genet A. 2019. PMID: 31145547

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