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MED1 IDR acetylation reorganizes the transcription preinitiation complex, rewires 3D chromatin interactions and reprograms gene expression.

Lin R, Barrows D, Mo Y, Onikubo T, Zhang Z, Roeder RG. Lin R, et al. bioRxiv [Preprint]. 2024 Mar 18:2024.03.18.585606. doi: 10.1101/2024.03.18.585606. bioRxiv. 2024. PMID: 38562677 Free PMC article. Preprint.

Effect of Med1 on T cell development and CD4⁺ T cell differentiation in immune response.

Zheng H, Jiao A, Liu H, Lei L, Ding R, Feng Z, Zhang D, Zhang L, Zhang B. Zheng H, et al. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2023 Sept 28;48(9):1296-1303. doi: 10.11817/j.issn.1672-7347.2023.220633. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2023. PMID: 38044640 Free PMC article. Chinese, English.

Characterization of Fusarium verticillioides Med1 LxxLL Motif Involved in Fumonisin Biosynthesis.

Zhou Z, Liu J, Zhang J, Yan H, Yi T, Shim WB. Zhou Z, et al. Toxins (Basel). 2023 Nov 13;15(11):652. doi: 10.3390/toxins15110652. Toxins (Basel). 2023. PMID: 37999515 Free PMC article.

Interactions between BRD4S, LOXL2, and MED1 drive cell cycle transcription in triple-negative breast cancer.

Pascual-Reguant L, Serra-Camprubí Q, Datta D, Cianferoni D, Kourtis S, Gañez-Zapater A, Cannatá C, Espinar L, Querol J, García-López L, Musa-Afaneh S, Guirola M, Gkanogiannis A, Miró Canturri A, Guzman M, Rodríguez O, Herencia-Ropero A, Arribas J, Serra V, Serrano L, Tian TV, Peiró S, Sdelci S. Pascual-Reguant L, et al. EMBO Mol Med. 2023 Dec 7;15(12):e18459. doi: 10.15252/emmm.202318459. Epub 2023 Nov 8. EMBO Mol Med. 2023. PMID: 37937685 Free PMC article.

Mediator subunit MED1 deficiency prevents carbon tetrachloride-induced hepatic fibrosis in mice.

Gao J, Bao M, Xing Y, Ding Y, Han T, Wen E, Liu J, Yue S, Wang R, Wang L, Liu J, Zhao S, Huang J, Liu E, Bai L. Gao J, et al. Am J Physiol Gastrointest Liver Physiol. 2023 Nov 1;325(5):G418-G428. doi: 10.1152/ajpgi.00076.2023. Epub 2023 Sep 5. Am J Physiol Gastrointest Liver Physiol. 2023. PMID: 37668531

MED1 induces M2 polarization of tumor-associated macrophages to aggravate breast cancer.

Shen Y, Zhou L, Xu M, Tan Z, Yao K, Wang W. Shen Y, et al. Genes Genomics. 2023 Dec;45(12):1517-1525. doi: 10.1007/s13258-023-01435-0. Epub 2023 Aug 18. Genes Genomics. 2023. PMID: 37594664

Retrospective analysis of dissemination of the 2.MED1 phylogenetic branch of Yersinia pestis in the Caucasus.

Eroshenko GA, Balykova AN, Nikiforov KA, Krasnov YM, Kukleva LM, Naryshkina EA, Kuznetsov AA, Popov NV, Kutyrev VV. Eroshenko GA, et al. PLoS One. 2023 Mar 29;18(3):e0283670. doi: 10.1371/journal.pone.0283670. eCollection 2023. PLoS One. 2023. PMID: 36989240 Free PMC article.

MED1 Ablation Promotes Oral Mucosal Wound Healing via JNK Signaling Pathway.

Meng Z, Li Z, Guo S, Wu D, Wei R, Liu J, Hu L, Sui L. Meng Z, et al. Int J Mol Sci. 2022 Nov 2;23(21):13414. doi: 10.3390/ijms232113414. Int J Mol Sci. 2022. PMID: 36362197 Free PMC article.

MED1 Regulates BMP/TGF-β in Endothelium: Implication for Pulmonary Hypertension.

Wang C, Xing Y, Zhang J, He M, Dong J, Chen S, Wu H, Huang HY, Chou CH, Bai L, He F, She J, Su A, Wang Y, Thistlethwaite PA, Huang HD, Yuan JX, Yuan ZY, Shyy JY. Wang C, et al. Circ Res. 2022 Oct 28;131(10):828-841. doi: 10.1161/CIRCRESAHA.122.321532. Epub 2022 Oct 14. Circ Res. 2022. PMID: 36252121 Free article.

MED1, a novel binding partner of BRCA1, regulates homologous recombination and R-loop processing.

Honjoh H, Tanikawa M, Wada-Hiraike O, Oda K, Inaba H, Kukita A, Kawata Y, Kusakabe M, Tsuchimochi S, Taguchi A, Miyamoto Y, Sone K, Tsuruga T, Mori-Uchino M, Matsumoto Y, Osuga Y. Honjoh H, et al. Sci Rep. 2022 Oct 13;12(1):17140. doi: 10.1038/s41598-022-21495-8. Sci Rep. 2022. PMID: 36229463 Free PMC article.

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