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38607037,38408720,38407246,38397115,38347786,38334186,38307244,38299799,38195857,38090351,38027588,38004490,37879570,37879239,37860832,37856911,37656756,37632317,37528667,37515249,37348028,37333789,37289497,37252973,37243180,37193327,37160141,37159959,37088168,37076471,37060797,37047816,36961231,36929720,36905944,36839463,36768218,36685072,36622141,36605638,36572150,36449607,36334638,36311427,36055002,36016449,35901648,35865937,35758665,35670457,35536870,35489297,35458761,35372666,35223766,35203378,35169264,34797876,34759006,34699863,34555732,34464815,34340648,34340199,34274831,34254908,34066055,34065634,33953197,33898335,33866234,33718704,33547379,33424251,33152438,33147489,32907977,32881988,32778820,32764551,32721859,32699085,32445444,32435384,32313955,32272626,32123831,32122868,32117232,32056715,32056710,31985225,31922712,31859616,31805205,31779251,31738758,31729469,31690057,31685463,31633391,31611100,31597763,31574966,31361901,31312076,31310806,31230744,31202975,31199156,31043530,30951555,30915447,30848123,30748015,30562608,30558110,30530224,30478404,30368131,29945503,29930069,29923677,29874999,29845531,29760190,29679079,29677482,29582535,29572905,29470500,29423529,29392497,29344662,29246851,29137867,28814513,28780191,28559152,28493152,28468880,28365387,28356528,28351337,28345656,28345600,28345596,28291746,28254839,28179530,28041959,27998085,27881649,27866982,27805221,27784988,27750202,27633330,27622521,27575636,27556406,27500641,27335310,27303800,27076639,27030586,26895240,26864387,26774922,26578813,26527147,26381649,26280817,26269182,26075394,26039671,25912817,25816318,25775415,25523420,25488659,25320292,25211074,25211068,25209234,24904061,24852307,24696348,24696345,24696341,24626302,24516322,24262074,24166946,24025331,23950717,23930976,23929244,23821274,23821273,23800076,23740481,23449064,23072882,22796133,22570514,22509919,22496660,22411725,22313305,22285573,22050318,22022449,22014111,21964598,21881953,21855635,21788392,21471248,21374358,21349834,21298455,20594569,20427624,20363326,20106931,20002303,19850911,19776234,19754307,19710254,19587048,19451286,19368702,19297323,19279106,19199833,19101564,19091993,18976670,18809436,18799181,18757072,18721058,18469001,18190994,18063164,18042258,17686489,17622627,17577613,17459929,17374759,17319160,17267492,17258730,17168837,16889685,16731929,16276867,16188985,16103156,16012009,15917225,15617244,15152003,15084396,12886419,12759980,12759961,12721805,12526350,12368319,12196827,12105224,12032088,11986688,11819699,11752143,11326014,11311426,11257177,11170049,11164916,11038810,10924011,10923525,10858497,10825933,10695037,10559344,10516033,10208852,10094977,9751009,9738071,9714237,9696822,9657959,9621090,9608667,9559535,9452298,9437896,9399495,9275470,9178492,9094618,8818959,8607261,8556499,8537460,8418788,8385698,8321152,8263114,8260866,8245854,8176367,8071535,7832643,7642575,7561771,7534821,7533125,7530398,7507461,7496964,2959795,2837017,2826667,1702914,1534119,1531368,1433530,38427645,38418391,38384473,38374154,38296832,38257807,38216506,38199140,38185072,38091143,37979208,37891235,37770825,37752651,37632104,37555662,37544570,37515188,37498862,37497735,37478848,37456879,37331645,37165438,37112962,37060263,36943525,36746341,36680231,36680227,36521285,36508435,36475764,36442102,36362200,36347437,36266496,36223838,36207405,36171757,36149812,36098513,36074777,36017362,36016440,36016333,35969917,35779336,35750488,35746707,35632818,35632712,35460509,35420134,35390695,35249454,35223554,35183126,35150893,35133637,34835014,34794468,34779427,34740635,34735113,34728345,34709635,34706234,34696835,34526049,34500343,34452310,34386905,34384937,34290707,34281569,34224111,34217305,34207869,34187544,34120252,34071102,34029593,33939805,33923511,33910950,33886274,33863991,33816326,33800884,33799742,33676573,33667623,33636637,33575893,33515283,33470443,33388393,33235334,33203823,33202554,33198381,33099859,33064724,32835694,32796069,32723369,32602297,32580028,32484211,32452412,32432721,32409874,32366663,32186498,32081658,32013149,31968613,31959201,31936331,31884102,31794691,31694207,31678478,31662457,31658680,31653397,31575036,31521822,31514688,31511049,31494268,31456950,31293584,31217052,31211661,31210384,31146046,31142664,31128447,31128224,31112134,31092581,31090210,31090058,31085207,30887540,30830717,30779959,30738967,30723263,30626442,30606229,30554071,30550790,30476788,30426316,30392049,30284630,30229544,30217517,30201873,30195251,30190720,30126417,30062973,29931514,29914165,29886373,29868504,29845537,29845535,29845534,29845532,29845529,29745301,29739068,29728337,29701642,29699483,29655579,29513820,29507368,29495257,29447178,29442067,29437963,29398345,29379028,29317641,29297316,29279447,29232534,29185594,29161301,29141913,29140541,29113891,29028178,29018253,28988109,28942836,28767984,28761113,28740124,28720531,28631054,28606155,28591405,28555540,28396347,28315476,28306743,28298448,28275182,28228595,28214373,28148797,28131854,28110248,28069884,28044043,28030579,27993851,27986564,2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The ZIKV NS5 Protein Aberrantly Alters the Tubulin Cytoskeleton, Induces the Accumulation of Autophagic p62 and Affects IFN Production: HDAC6 Has Emerged as an Anti-NS5/ZIKV Factor.

Pérez-Yanes S, Lorenzo-Sánchez I, Cabrera-Rodríguez R, García-Luis J, Trujillo-González R, Estévez-Herrera J, Valenzuela-Fernández A. Pérez-Yanes S, et al. Cells. 2024 Mar 29;13(7):598. doi: 10.3390/cells13070598. Cells. 2024. PMID: 38607037 Free PMC article.

Characterization of SLA RNA promoter from dengue virus and its interaction with the viral non-structural NS5 protein.

Brillet K, Janczuk-Richter M, Poon A, Laukart-Bradley J, Ennifar E, Lebars I. Brillet K, et al. Biochimie. 2024 Feb 24;222:87-100. doi: 10.1016/j.biochi.2024.02.005. Online ahead of print. Biochimie. 2024. PMID: 38408720

Structural and energetic analysis of NS5 protein inhibition by small molecules in Japanese encephalitis virus using machine learning and steered molecular dynamics approach.

Alhazmi AY, Khan FR, Rehman ZU, Hazazi A, Alotaibi BS, Alharthi NS, Alhuthali HM, Aba Alkhayl FF, Alshehri FF, Alkhoshaiban A, Al-Otaibi F. Alhazmi AY, et al. J Biomol Struct Dyn. 2024 Feb 26:1-18. doi: 10.1080/07391102.2024.2316767. Online ahead of print. J Biomol Struct Dyn. 2024. PMID: 38407246

Identification of Novel Non-Nucleoside Inhibitors of Zika Virus NS5 Protein Targeting MTase Activity.

Fiorucci D, Meaccini M, Poli G, Stincarelli MA, Vagaggini C, Giannecchini S, Sutto-Ortiz P, Canard B, Decroly E, Dreassi E, Brai A, Botta M. Fiorucci D, et al. Int J Mol Sci. 2024 Feb 19;25(4):2437. doi: 10.3390/ijms25042437. Int J Mol Sci. 2024. PMID: 38397115 Free PMC article.

Binding of Nucleotide Inhibitors to the NS5 RdRp of the ZIKA Virus in the Replication Initiation State.

Pant S, Jena NR. Pant S, et al. Curr Med Chem. 2024 Feb 12. doi: 10.2174/0109298673259914231213052438. Online ahead of print. Curr Med Chem. 2024. PMID: 38347786

Identification and characterization of domain-specific inhibitors of DENV NS3 and NS5 proteins by in silico screening methods.

Samuel J, Ghosh S, Thiyagarajan S. Samuel J, et al. J Biomol Struct Dyn. 2024 Feb 9:1-15. doi: 10.1080/07391102.2024.2313161. Online ahead of print. J Biomol Struct Dyn. 2024. PMID: 38334186

Cell cycle and mitosis progression during ZIKA virus infection: The viral non-structural protein NS5 as a master regulator of the APC/cyclosome?

Lebeau G, Hoareau M, Rivière S, El Safadi D, Da Silva CR, Krejbich-Trotot P, Viranaicken W. Lebeau G, et al. Biochimie. 2024 Feb 1;221:75-80. doi: 10.1016/j.biochi.2024.01.016. Online ahead of print. Biochimie. 2024. PMID: 38307244

A conserved methyltransferase active site residue of Zika virus NS5 is required for the restriction of STING activation and interferon expression.

Li Y, Li Z, Zou H, Zhou P, Huo Y, Fan Y, Liu X, Wu J, Li G, Wang X. Li Y, et al. J Gen Virol. 2024 Feb;105(2). doi: 10.1099/jgv.0.001954. J Gen Virol. 2024. PMID: 38299799

A conformational selection mechanism of flavivirus NS5 for species-specific STAT2 inhibition.

Biswal M, Yao W, Lu J, Chen J, Morrison J, Hai R, Song J. Biswal M, et al. Commun Biol. 2024 Jan 10;7(1):76. doi: 10.1038/s42003-024-05768-8. Commun Biol. 2024. PMID: 38195857 Free PMC article.

Docking and MM study of non-structural protein (NS5) of Japanese Encephalitis Virus (JEV) with some derivatives of adenosyl.

Tiwari RK, Pandey V, Srivastava H, Srivastava AK, Pandey V. Tiwari RK, et al. Front Chem. 2023 Nov 27;11:1258764. doi: 10.3389/fchem.2023.1258764. eCollection 2023. Front Chem. 2023. PMID: 38090351 Free PMC article.

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