Characterisation of a mobilisable plasmid conferring florfenicol and chloramphenicol resistance in Actinobacillus pleuropneumoniae

Vet Microbiol. 2015 Aug 5;178(3-4):279-82. doi: 10.1016/j.vetmic.2015.05.020. Epub 2015 May 28.

Abstract

The complete nucleotide sequence of a 7.7kb mobilisable plasmid (pM3446F), isolated from a florfenicol resistant isolate of Actinobacillus pleuropneumoniae, showed extended similarity to plasmids found in other members of the Pasteurellaceae containing the floR gene as well as replication and mobilisation genes. Mobilisation into other Pasteurellaceae species confirmed that this plasmid can be transferred horizontally.

MeSH terms

  • Actinobacillus Infections / microbiology*
  • Actinobacillus pleuropneumoniae / drug effects*
  • Actinobacillus pleuropneumoniae / genetics
  • Animals
  • Base Sequence
  • Chloramphenicol Resistance / genetics
  • Drug Resistance, Bacterial / genetics*
  • Molecular Sequence Data
  • Pasteurellaceae / genetics*
  • Pasteurellaceae / isolation & purification
  • Pasteurellaceae Infections / microbiology*
  • Plasmids / genetics*
  • Sequence Analysis, DNA
  • Swine
  • Swine Diseases / microbiology*
  • Thiamphenicol / analogs & derivatives
  • Thiamphenicol / pharmacology

Substances

  • florfenicol
  • Thiamphenicol

Associated data

  • GENBANK/KP696484