Molecular mechanisms of macrolide resistance in clinical isolates of Mycoplasma pneumoniae from China

Antimicrob Agents Chemother. 2009 May;53(5):2158-9. doi: 10.1128/AAC.01563-08. Epub 2009 Mar 9.

Abstract

Fifty clinical Mycoplasma pneumoniae strains were isolated from 370 children with respiratory tract infections. Four strains were susceptible to macrolides, while the other 46 (92%) were macrolide resistant. The molecular mechanism of resistance was shown to be associated with point mutations in 23S rRNA at positions 2063 and 2064.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Child
  • China
  • Drug Resistance, Bacterial / genetics*
  • Humans
  • Macrolides / pharmacology*
  • Microbial Sensitivity Tests
  • Mycoplasma pneumoniae / drug effects*
  • Mycoplasma pneumoniae / genetics
  • Mycoplasma pneumoniae / isolation & purification
  • Pneumonia, Mycoplasma / microbiology
  • Point Mutation
  • RNA, Ribosomal, 23S / genetics*
  • Respiratory Tract Infections / microbiology

Substances

  • Anti-Bacterial Agents
  • Macrolides
  • RNA, Ribosomal, 23S