PubMed (MeSH Keyword) for id: 135564890

Year	Number of Results
2016	6
2017	12
2018	10
2019	14
2020	11
2021	8
2022	4
2023	7
2024	1

1

Epacadostat stabilizes the apo-form of IDO1 and signals a pro-tumorigenic pathway in human ovarian cancer cells.

Rossini S, Ambrosino S, Volpi C, Belladonna ML, Pallotta MT, Panfili E, Suvieri C, Macchiarulo A, Mondanelli G, Orabona C. Rossini S, et al. Front Immunol. 2024 Jan 25;15:1346686. doi: 10.3389/fimmu.2024.1346686. eCollection 2024. Front Immunol. 2024. PMID: 38333210 Free PMC article.

2

Sphingomyelin-derived nanovesicles for the delivery of the IDO1 inhibitor epacadostat enhance metastatic and post-surgical melanoma immunotherapy.

Wang Z, Li W, Jiang Y, Tran TB, Cordova LE, Chung J, Kim M, Wondrak G, Erdrich J, Lu J. Wang Z, et al. Nat Commun. 2023 Nov 9;14(1):7235. doi: 10.1038/s41467-023-43079-4. Nat Commun. 2023. PMID: 37945606 Free PMC article.

3

The catalytic inhibitor epacadostat can affect the non-enzymatic function of IDO1.

Panfili E, Mondanelli G, Orabona C, Gargaro M, Volpi C, Belladonna ML, Rossini S, Suvieri C, Pallotta MT. Panfili E, et al. Front Immunol. 2023 Apr 14;14:1134551. doi: 10.3389/fimmu.2023.1134551. eCollection 2023. Front Immunol. 2023. PMID: 37122718 Free PMC article.

4

Phase I/II sequencing study of azacitidine, epacadostat, and pembrolizumab in advanced solid tumors.

Luke JJ, Fakih M, Schneider C, Chiorean EG, Bendell J, Kristeleit R, Kurzrock R, Blagden SP, Brana I, Goff LW, O'Hayer K, Geschwindt R, Smith M, Zhou F, Naing A. Luke JJ, et al. Br J Cancer. 2023 Jun;128(12):2227-2235. doi: 10.1038/s41416-023-02267-1. Epub 2023 Apr 22. Br J Cancer. 2023. PMID: 37087488 Free PMC article. Clinical Trial.

5

Targeting the tumor microenvironment by liposomal Epacadostat in combination with liposomal gp100 vaccine.

Tahaghoghi-Hajghorbani S, Yazdani M, Nikpoor AR, Hatamipour M, Ajami A, Jaafari MR, Badiee A, Rafiei A. Tahaghoghi-Hajghorbani S, et al. Sci Rep. 2023 Apr 10;13(1):5802. doi: 10.1038/s41598-023-31007-x. Sci Rep. 2023. PMID: 37037839 Free PMC article.

6

A Phase II Study of Epacadostat and Pembrolizumab in Patients with Advanced Sarcoma.

Kelly CM, Qin LX, Whiting KA, Richards AL, Avutu V, Chan JE, Chi P, Dickson MA, Gounder MM, Keohan ML, Movva S, Nacev BA, Rosenbaum E, Adamson T, Singer S, Bartlett EK, Crago AM, Yoon SS, Hwang S, Erinjeri JP, Antonescu CR, Tap WD, D'Angelo SP. Kelly CM, et al. Clin Cancer Res. 2023 Jun 1;29(11):2043-2051. doi: 10.1158/1078-0432.CCR-22-3911. Clin Cancer Res. 2023. PMID: 36971773 Free PMC article. Clinical Trial.

7

Design, synthesis, biological evaluation of urea substituted 1,2,5-oxadiazole-3-carboximidamides as novel indoleamine 2,3-dioxygenase-1 (IDO1) inhibitors.

Ye K, Wang K, Wang T, Tang H, Wang L, Zhang W, Jiang S, Zhang X, Zhang K. Ye K, et al. Eur J Med Chem. 2023 Mar 15;250:115217. doi: 10.1016/j.ejmech.2023.115217. Epub 2023 Feb 20. Eur J Med Chem. 2023. PMID: 36842272

8

Phase 1/2 study of epacadostat in combination with durvalumab in patients with metastatic solid tumors.

Naing A, Algazi AP, Falchook GS, Creelan BC, Powderly J, Rosen S, Barve M, Mettu NB, Triozzi PL, Hamm J, Zhou G, Walker C, Dong Z, Patel MR. Naing A, et al. Cancer. 2023 Jan 1;129(1):71-81. doi: 10.1002/cncr.34512. Epub 2022 Oct 30. Cancer. 2023. PMID: 36309837 Free PMC article. Clinical Trial.

9

IDO1 Is a Therapeutic Target for Pancreatic Cancer-Associated Depression.

Hue JJ, Graor HJ, Zarei M, Katayama ES, Ji K, Hajihassani O, Loftus AW, Vaziri-Gohar A, Winter JM. Hue JJ, et al. Mol Cancer Ther. 2022 Dec 2;21(12):1810-1822. doi: 10.1158/1535-7163.MCT-22-0055. Mol Cancer Ther. 2022. PMID: 36190971

10

Epacadostat Plus Pembrolizumab and Chemotherapy for Advanced Solid Tumors: Results from the Phase I/II ECHO-207/KEYNOTE-723 Study.

Powderly JD, Klempner SJ, Naing A, Bendell J, Garrido-Laguna I, Catenacci DVT, Taylor MH, Lee JJ, Zheng F, Zhou F, Gong X, Gowda H, Beatty GL. Powderly JD, et al. Oncologist. 2022 Nov 3;27(11):905-e848. doi: 10.1093/oncolo/oyac174. Oncologist. 2022. PMID: 36156099 Free PMC article. Clinical Trial.

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