Saposin fold revealed by the NMR structure of NK-lysin

Nat Struct Biol. 1997 Oct;4(10):793-5. doi: 10.1038/nsb1097-793.

Abstract

NK-lysin is the first representative of a family of sequence related proteins--saposins, surfactant-associated protein B, pore forming amoeba proteins, and domains of acid sphingomyelinase, acyloxyacylhydrolase and plant aspartic proteinases--for which a structure has been determined.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Conserved Sequence
  • Disulfides
  • Glycoproteins / chemistry*
  • Humans
  • Molecular Sequence Data
  • Nuclear Magnetic Resonance, Biomolecular
  • Protein Conformation*
  • Protein Folding*
  • Protein Structure, Secondary
  • Proteolipids / chemistry*
  • Pulmonary Surfactants / chemistry*
  • Saposins
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Sphingolipid Activator Proteins
  • Swine

Substances

  • Disulfides
  • Glycoproteins
  • NK-lysin
  • PSAP protein, human
  • Proteolipids
  • Pulmonary Surfactants
  • Saposins
  • Sphingolipid Activator Proteins