Abstract
A divergently oriented ampR has been located upstream of blaL2 in Stenotrophomonas maltophilia. AmpR is necessary for L1 and L2 beta-lactamase induction in response to beta-lactam challenge, and activation of AmpR is sufficient to induce L1 and L2 production. L1 induction requires more activation of AmpR than does L2 induction.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Bacterial Proteins / metabolism*
-
Enzyme Induction*
-
Gene Expression Regulation, Bacterial*
-
Genes, Regulator
-
Humans
-
Mutation
-
Stenotrophomonas maltophilia / drug effects
-
Stenotrophomonas maltophilia / enzymology*
-
Stenotrophomonas maltophilia / genetics
-
Stenotrophomonas maltophilia / growth & development
-
beta-Lactamases / biosynthesis*
-
beta-Lactamases / genetics
-
beta-Lactams / pharmacology
Substances
-
Bacterial Proteins
-
beta-Lactams
-
AmpR protein, Bacteria
-
beta-lactamase L1
-
beta-lactamase L2
-
beta-Lactamases