18725974 22162589 18676830 15254419 26619011 20453058 22162582 15647370 15805248[uid] - Search Results

Year	Number of Results
2004	1
2005	2
2008	2
2010	1
2011	2
2012	2
2015	1
2016	1
2024	0

1

Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling.

She QB, Chandarlapaty S, Ye Q, Lobo J, Haskell KM, Leander KR, DeFeo-Jones D, Huber HE, Rosen N. She QB, et al. PLoS One. 2008 Aug 26;3(8):e3065. doi: 10.1371/journal.pone.0003065. PLoS One. 2008. PMID: 18725974 Free PMC article.

2

Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors.

Bendell JC, Rodon J, Burris HA, de Jonge M, Verweij J, Birle D, Demanse D, De Buck SS, Ru QC, Peters M, Goldbrunner M, Baselga J. Bendell JC, et al. J Clin Oncol. 2012 Jan 20;30(3):282-90. doi: 10.1200/JCO.2011.36.1360. Epub 2011 Dec 12. J Clin Oncol. 2012. PMID: 22162589 Clinical Trial.

3

An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer.

Stemke-Hale K, Gonzalez-Angulo AM, Lluch A, Neve RM, Kuo WL, Davies M, Carey M, Hu Z, Guan Y, Sahin A, Symmans WF, Pusztai L, Nolden LK, Horlings H, Berns K, Hung MC, van de Vijver MJ, Valero V, Gray JW, Bernards R, Mills GB, Hennessy BT. Stemke-Hale K, et al. Cancer Res. 2008 Aug 1;68(15):6084-91. doi: 10.1158/0008-5472.CAN-07-6854. Cancer Res. 2008. PMID: 18676830 Free PMC article.

4

The PIK3CA gene is mutated with high frequency in human breast cancers.

Bachman KE, Argani P, Samuels Y, Silliman N, Ptak J, Szabo S, Konishi H, Karakas B, Blair BG, Lin C, Peters BA, Velculescu VE, Park BH. Bachman KE, et al. Cancer Biol Ther. 2004 Aug;3(8):772-5. doi: 10.4161/cbt.3.8.994. Epub 2004 Aug 26. Cancer Biol Ther. 2004. PMID: 15254419

5

Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

Chang MT, Asthana S, Gao SP, Lee BH, Chapman JS, Kandoth C, Gao J, Socci ND, Solit DB, Olshen AB, Schultz N, Taylor BS. Chang MT, et al. Nat Biotechnol. 2016 Feb;34(2):155-63. doi: 10.1038/nbt.3391. Epub 2015 Nov 30. Nat Biotechnol. 2016. PMID: 26619011 Free PMC article.

6

Predictive biomarkers of sensitivity to the phosphatidylinositol 3' kinase inhibitor GDC-0941 in breast cancer preclinical models.

O'Brien C, Wallin JJ, Sampath D, GuhaThakurta D, Savage H, Punnoose EA, Guan J, Berry L, Prior WW, Amler LC, Belvin M, Friedman LS, Lackner MR. O'Brien C, et al. Clin Cancer Res. 2010 Jul 15;16(14):3670-83. doi: 10.1158/1078-0432.CCR-09-2828. Epub 2010 May 7. Clin Cancer Res. 2010. PMID: 20453058

7

Phosphatidylinositide-3-kinase inhibitors: addressing questions of isoform selectivity and pharmacodynamic/predictive biomarkers in early clinical trials.

Clarke PA, Workman P. Clarke PA, et al. J Clin Oncol. 2012 Jan 20;30(3):331-3. doi: 10.1200/JCO.2011.38.7167. Epub 2011 Dec 12. J Clin Oncol. 2012. PMID: 22162582 No abstract available.

8

Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic.

Kang S, Bader AG, Vogt PK. Kang S, et al. Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):802-7. doi: 10.1073/pnas.0408864102. Epub 2005 Jan 12. Proc Natl Acad Sci U S A. 2005. PMID: 15647370 Free PMC article.

9

PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma.

Saal LH, Holm K, Maurer M, Memeo L, Su T, Wang X, Yu JS, Malmström PO, Mansukhani M, Enoksson J, Hibshoosh H, Borg A, Parsons R. Saal LH, et al. Cancer Res. 2005 Apr 1;65(7):2554-9. doi: 10.1158/0008-5472-CAN-04-3913. Cancer Res. 2005. PMID: 15805248

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