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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1974 1
1975 1
1979 1
1980 1
1982 1
1983 1
1984 2
1985 2
1987 2
1988 1
1989 3
1990 3
1991 2
1992 6
1993 4
1994 2
1995 3
1996 4
1997 4
1998 8
1999 4
2000 16
2001 9
2002 8
2003 7
2004 16
2005 21
2006 12
2007 22
2008 12
2009 14
2010 25
2011 22
2012 14
2013 19
2014 17
2015 20
2016 19
2017 28
2018 19
2019 13
2020 24
2021 22
2022 16
2023 19
2024 11

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418 results

Results by year

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Page 1
Ferroptosis: molecular mechanisms and health implications.
Tang D, Chen X, Kang R, Kroemer G. Tang D, et al. Cell Res. 2021 Feb;31(2):107-125. doi: 10.1038/s41422-020-00441-1. Epub 2020 Dec 2. Cell Res. 2021. PMID: 33268902 Free PMC article. Review.
Ferroptosis can occur through two major pathways, the extrinsic or transporter-dependent pathway and the intrinsic or enzyme-regulated pathway. Ferroptosis is caused by a redox imbalance between the production of oxidants and antioxidants, which is driven by the abnorma …
Ferroptosis can occur through two major pathways, the extrinsic or transporter-dependent pathway and the intrinsic or enzyme-regulated pathw …
Pathophysiology of Sickle Cell Disease.
Sundd P, Gladwin MT, Novelli EM. Sundd P, et al. Annu Rev Pathol. 2019 Jan 24;14:263-292. doi: 10.1146/annurev-pathmechdis-012418-012838. Epub 2018 Oct 17. Annu Rev Pathol. 2019. PMID: 30332562 Free PMC article. Review.
Vaso-occlusive events and intravascular hemolysis promote inflammation and redox instability that lead to progressive small- and large-vessel vasculopathy. Based on current evidence, the pathobiology of SCD is considered to be a vicious cycle of four major processes, all t …
Vaso-occlusive events and intravascular hemolysis promote inflammation and redox instability that lead to progressive small- and larg …
Cancer Metabolism: Phenotype, Signaling and Therapeutic Targets.
Park JH, Pyun WY, Park HW. Park JH, et al. Cells. 2020 Oct 16;9(10):2308. doi: 10.3390/cells9102308. Cells. 2020. PMID: 33081387 Free PMC article. Review.
Aberrant metabolism is a major hallmark of cancer. Abnormal cancer metabolism, such as aerobic glycolysis and increased anabolic pathways, has important roles in tumorigenesis, metastasis, drug resistance, and cancer stem cells. Well-known oncogenic signaling pathways, suc …
Aberrant metabolism is a major hallmark of cancer. Abnormal cancer metabolism, such as aerobic glycolysis and increased anabolic path …
Oxidative stress and diabetic retinopathy: Molecular mechanisms, pathogenetic role and therapeutic implications.
Kang Q, Yang C. Kang Q, et al. Redox Biol. 2020 Oct;37:101799. doi: 10.1016/j.redox.2020.101799. Epub 2020 Nov 13. Redox Biol. 2020. PMID: 33248932 Free PMC article. Review.
Oxidative stress can both contribute to and result from the metabolic abnormalities induced by hyperglycemia, mainly including the increased flux of the polyol pathway and hexosamine pathway, the hyper-activation of protein kinase C (PKC) isoforms, and the accumulat …
Oxidative stress can both contribute to and result from the metabolic abnormalities induced by hyperglycemia, mainly including the in …
Hypoxic Pulmonary Vasoconstriction: From Molecular Mechanisms to Medicine.
Dunham-Snary KJ, Wu D, Sykes EA, Thakrar A, Parlow LRG, Mewburn JD, Parlow JL, Archer SL. Dunham-Snary KJ, et al. Chest. 2017 Jan;151(1):181-192. doi: 10.1016/j.chest.2016.09.001. Epub 2016 Sep 16. Chest. 2017. PMID: 27645688 Free PMC article. Review.
In response to alveolar hypoxia, a mitochondrial sensor dynamically changes reactive oxygen species and redox couples in pulmonary artery smooth muscle cells (PASMC). This inhibits potassium channels, depolarizes PASMC, activates voltage-gated calcium channels, and …
In response to alveolar hypoxia, a mitochondrial sensor dynamically changes reactive oxygen species and redox couples in pulmonary ar …
AMPK, Mitochondrial Function, and Cardiovascular Disease.
Wu S, Zou MH. Wu S, et al. Int J Mol Sci. 2020 Jul 15;21(14):4987. doi: 10.3390/ijms21144987. Int J Mol Sci. 2020. PMID: 32679729 Free PMC article. Review.
Adenosine monophosphate-activated protein kinase (AMPK) is in charge of numerous catabolic and anabolic signaling pathways to sustain appropriate intracellular adenosine triphosphate levels in response to energetic and/or cellular stress. ...Accumulating studies have demon …
Adenosine monophosphate-activated protein kinase (AMPK) is in charge of numerous catabolic and anabolic signaling pathways to sustain …
Physiological and pathophysiological roles of NAMPT and NAD metabolism.
Garten A, Schuster S, Penke M, Gorski T, de Giorgis T, Kiess W. Garten A, et al. Nat Rev Endocrinol. 2015 Sep;11(9):535-46. doi: 10.1038/nrendo.2015.117. Epub 2015 Jul 28. Nat Rev Endocrinol. 2015. PMID: 26215259 Review.
Through its NAD-biosynthetic activity, NAMPT influences the activity of NAD-dependent enzymes, thereby regulating cellular metabolism. In addition to its enzymatic function, extracellular NAMPT (eNAMPT) has cytokine-like activity. Abnormal levels of eN …
Through its NAD-biosynthetic activity, NAMPT influences the activity of NAD-dependent enzymes, thereby regulating cellular met …
Metabolic Reprogramming of Colorectal Cancer Cells and the Microenvironment: Implication for Therapy.
Nenkov M, Ma Y, Gaßler N, Chen Y. Nenkov M, et al. Int J Mol Sci. 2021 Jun 10;22(12):6262. doi: 10.3390/ijms22126262. Int J Mol Sci. 2021. PMID: 34200820 Free PMC article. Review.
Metabolic reprogramming, a hallmark of cancer, is closely related to the initiation and progression of carcinomas, including CRC. Accumulating evidence shows that activation of oncogenic pathways and loss of tumor suppressor genes regulate the metabolic reprogramming that …
Metabolic reprogramming, a hallmark of cancer, is closely related to the initiation and progression of carcinomas, including CRC. Accumulati …
Metabolic features of the cell danger response.
Naviaux RK. Naviaux RK. Mitochondrion. 2014 May;16:7-17. doi: 10.1016/j.mito.2013.08.006. Epub 2013 Aug 24. Mitochondrion. 2014. PMID: 23981537 Free article. Review.
After the danger has been eliminated or neutralized, a choreographed sequence of anti-inflammatory and regenerative pathways is activated to reverse the CDR and to heal. When the CDR persists abnormally, whole body metabolism and the gut microbiome are disturbed, th …
After the danger has been eliminated or neutralized, a choreographed sequence of anti-inflammatory and regenerative pathways is activated …
The role of mitochondrial dysfunction in cardiovascular disease: a brief review.
Chistiakov DA, Shkurat TP, Melnichenko AA, Grechko AV, Orekhov AN. Chistiakov DA, et al. Ann Med. 2018 Mar;50(2):121-127. doi: 10.1080/07853890.2017.1417631. Epub 2017 Dec 18. Ann Med. 2018. PMID: 29237304 Review.
In CVD, such an adaptation is impaired, which, in turn, leads to a progressive decline of the mitochondrial function associated with abnormalities in the respiratory chain and ATP synthesis, increased oxidative stress, and loss of the structural integrity of mitochondria. …
In CVD, such an adaptation is impaired, which, in turn, leads to a progressive decline of the mitochondrial function associated with abno …
418 results