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1977
2025

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1977 2
1984 1
1985 1
1986 4
1987 5
1989 2
1990 5
1991 7
1992 4
1993 7
1994 4
1995 4
1996 8
1997 9
1998 12
1999 5
2000 14
2001 10
2002 14
2003 10
2004 16
2005 17
2006 15
2007 13
2008 12
2009 17
2010 15
2011 19
2012 14
2013 21
2014 19
2015 22
2016 35
2017 53
2018 65
2019 77
2020 96
2021 102
2022 96
2023 110
2024 90
2025 7

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951 results

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Page 1
Atherosclerosis: Recent developments.
Björkegren JLM, Lusis AJ. Björkegren JLM, et al. Cell. 2022 May 12;185(10):1630-1645. doi: 10.1016/j.cell.2022.04.004. Epub 2022 May 2. Cell. 2022. PMID: 35504280 Free PMC article. Review.
We place an emphasis on recent developments, some of which have yielded unexpected biology, including previously unknown heterogeneity of inflammatory and smooth muscle cells in atherosclerotic lesions, roles for senescence and clonal hematopoiesis, and links to the …
We place an emphasis on recent developments, some of which have yielded unexpected biology, including previously unknown heterogeneity of in …
Clonal hematopoiesis in human aging and disease.
Jaiswal S, Ebert BL. Jaiswal S, et al. Science. 2019 Nov 1;366(6465):eaan4673. doi: 10.1126/science.aan4673. Science. 2019. PMID: 31672865 Free PMC article. Review.
When this process happens in the hematopoietic system, a substantial proportion of circulating blood cells may derive from a single mutated stem cell. This outgrowth, called "clonal hematopoiesis," is highly prevalent in the elderly population. Here we discuss recen …
When this process happens in the hematopoietic system, a substantial proportion of circulating blood cells may derive from a single mutated …
Pathophysiology of Acute Myeloid Leukemia.
Wachter F, Pikman Y. Wachter F, et al. Acta Haematol. 2024;147(2):229-246. doi: 10.1159/000536152. Epub 2024 Feb 16. Acta Haematol. 2024. PMID: 38228114 Free article. Review.
Sequential acquisition of mutations leads to expanded proliferation of clonal myeloid progenitors and failure of differentiation, leading to fulminant AML. SUMMARY: Here, we review the pathophysiology of AML with a focus on factors predisposing to AML development, includin …
Sequential acquisition of mutations leads to expanded proliferation of clonal myeloid progenitors and failure of differentiation, lea …
Clonal hematopoiesis of indeterminate potential (CHIP): Linking somatic mutations, hematopoiesis, chronic inflammation and cardiovascular disease.
Marnell CS, Bick A, Natarajan P. Marnell CS, et al. J Mol Cell Cardiol. 2021 Dec;161:98-105. doi: 10.1016/j.yjmcc.2021.07.004. Epub 2021 Jul 21. J Mol Cell Cardiol. 2021. PMID: 34298011 Free PMC article. Review.
Clonal hematopoiesis of indeterminate potential (CHIP) is the presence of a clonally expanded hematopoietic stem cell caused by a leukemogenic mutation in individuals without evidence of hematologic malignancy, dysplasia, or cytopenia. ...Heritable and acquired risk
Clonal hematopoiesis of indeterminate potential (CHIP) is the presence of a clonally expanded hematopoietic stem cell caused b
Causes and consequences of clonal hematopoiesis.
Weeks LD, Ebert BL. Weeks LD, et al. Blood. 2023 Dec 28;142(26):2235-2246. doi: 10.1182/blood.2023022222. Blood. 2023. PMID: 37931207 Free PMC article. Review.
Clonal hematopoiesis (CH) is described as the outsized contribution of expanded clones of hematopoietic stem and progenitor cells (HSPCs) to blood cell production. The prevalence of CH increases dramatically with age. CH can be caused by somatic mutations in
Clonal hematopoiesis (CH) is described as the outsized contribution of expanded clones of hematopoietic stem and progenitor ce
Clonal hematopoiesis, somatic mosaicism, and age-associated disease.
Evans MA, Walsh K. Evans MA, et al. Physiol Rev. 2023 Jan 1;103(1):649-716. doi: 10.1152/physrev.00004.2022. Epub 2022 Sep 1. Physiol Rev. 2023. PMID: 36049115 Free PMC article. Review.
Somewhat unexpectedly, epidemiological studies have found that clonal hematopoiesis is associated with an increase in the risk of all-cause mortality and age-related disease, particularly in the cardiovascular system. ...Here we provide an up-to-date r …
Somewhat unexpectedly, epidemiological studies have found that clonal hematopoiesis is associated with an increase in the risk …
Diagnosis and Treatment of Aplastic Anemia.
Peslak SA, Olson T, Babushok DV. Peslak SA, et al. Curr Treat Options Oncol. 2017 Nov 16;18(12):70. doi: 10.1007/s11864-017-0511-z. Curr Treat Options Oncol. 2017. PMID: 29143887 Free PMC article. Review.
With the recent appreciation of frequent clonal hematopoiesis in AA patients and with the growing use of next-generation sequencing in the clinic, utmost caution should be exercised in interpreting the significance of somatic mutations in AA. Future longitudinal stu …
With the recent appreciation of frequent clonal hematopoiesis in AA patients and with the growing use of next-generation seque …
Clonal Hematopoiesis, Inflammation, and Hematologic Malignancy.
Kanagal-Shamanna R, Beck DB, Calvo KR. Kanagal-Shamanna R, et al. Annu Rev Pathol. 2024 Jan 24;19:479-506. doi: 10.1146/annurev-pathmechdis-051222-122724. Epub 2023 Oct 13. Annu Rev Pathol. 2024. PMID: 37832948 Free article. Review.
Tremendous advancements over the past years have led to a deeper understanding of the role of somatic mutations in benign and malignant age-related diseases. Here, we review the somatic mutations that accumulate in the blood and their connection to disease states, w …
Tremendous advancements over the past years have led to a deeper understanding of the role of somatic mutations in benign and malignant a
JAK: Not Just Another Kinase.
Agashe RP, Lippman SM, Kurzrock R. Agashe RP, et al. Mol Cancer Ther. 2022 Dec 2;21(12):1757-1764. doi: 10.1158/1535-7163.MCT-22-0323. Mol Cancer Ther. 2022. PMID: 36252553 Free PMC article. Review.
Somatic gain-of-function JAK mutations mainly occur in hematologic malignancies, with the activating JAK2 V617F being a myeloproliferative disorder hallmark; it is also seen in clonal hematopoiesis of indeterminate potential. Several T-cell malignancies, as well as …
Somatic gain-of-function JAK mutations mainly occur in hematologic malignancies, with the activating JAK2 V617F being a myeloproliferative d …
Genetic basis and molecular profiling in myeloproliferative neoplasms.
Luque Paz D, Kralovics R, Skoda RC. Luque Paz D, et al. Blood. 2023 Apr 20;141(16):1909-1921. doi: 10.1182/blood.2022017578. Blood. 2023. PMID: 36347013 Free PMC article. Review.
BCR::ABL1-negative myeloproliferative neoplasms (MPNs) are clonal diseases originating from a single hematopoietic stem cell that cause excessive production of mature blood cells. ...Factors that control the conversion from clonal hematopoiesis to MPN disease …
BCR::ABL1-negative myeloproliferative neoplasms (MPNs) are clonal diseases originating from a single hematopoietic stem cell that cau …
951 results