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Insights into elastic fiber fragmentation: Mechanisms and treatment of aortic aneurysm in Marfan syndrome.
Seeburun S, Wu S, Hemani D, Pham L, Ju D, Xie Y, Kata P, Li L. Seeburun S, et al. Vascul Pharmacol. 2023 Dec;153:107215. doi: 10.1016/j.vph.2023.107215. Epub 2023 Aug 26. Vascul Pharmacol. 2023. PMID: 37640090 Review.
Elastic fiber fragmentation in the aortic vessel wall is a hallmark of MFS-associated aortic aneurysms. FBN1 mutations result in FBN1 fragments that also contribute to elastic fiber fragmentation. Although recent rese
Elastic fiber fragmentation in the aortic vessel wall is a hallmark of MFS-associated aortic aneurysms. F
Consensus statement on surgical pathology of the aorta from the Society for Cardiovascular Pathology and the Association For European Cardiovascular Pathology: II. Noninflammatory degenerative diseases - nomenclature and diagnostic criteria.
Halushka MK, Angelini A, Bartoloni G, Basso C, Batoroeva L, Bruneval P, Buja LM, Butany J, d'Amati G, Fallon JT, Gallagher PJ, Gittenberger-de Groot AC, Gouveia RH, Kholova I, Kelly KL, Leone O, Litovsky SH, Maleszewski JJ, Miller DV, Mitchell RN, Preston SD, Pucci A, Radio SJ, Rodriguez ER, Sheppard MN, Stone JR, Suvarna SK, Tan CD, Thiene G, Veinot JP, van der Wal AC. Halushka MK, et al. Cardiovasc Pathol. 2016 May-Jun;25(3):247-257. doi: 10.1016/j.carpath.2016.03.002. Epub 2016 Mar 12. Cardiovasc Pathol. 2016. PMID: 27031798 Review.
Surgical aortic specimens are usually examined in Pathology Departments as a result of treatment of aneurysms or dissections. ...This consensus document has established a revised, unified nomenclature for the variety of noninflammatory degenerative aortic histopatho …
Surgical aortic specimens are usually examined in Pathology Departments as a result of treatment of aneurysms or dissections. ...This …
Histologic and morphologic character of pediatric abdominal aortic developmental coarctation and hypoplasia.
Heider A, Gordon D, Coleman DM, Eliason JL, Ganesh SK, Stanley JC. Heider A, et al. J Vasc Surg. 2022 Aug;76(2):556-563.e4. doi: 10.1016/j.jvs.2022.01.121. Epub 2022 Feb 9. J Vasc Surg. 2022. PMID: 35149163 Free article. Review.
Concentric or eccentric intimal fibroplasia was observed in every aorta, often with internal elastic fragmentation and duplication (n = 4). Media abnormalities included elastic tissue disorganization (n = 3) and focal medial fibrosis (n = 1). .. …
Concentric or eccentric intimal fibroplasia was observed in every aorta, often with internal elastic fragmentation and …
Bicuspid aortic valve: The most frequent and not so benign congenital heart disease.
Thiene G, Rizzo S, Basso C. Thiene G, et al. Cardiovasc Pathol. 2024 May-Jun;70:107604. doi: 10.1016/j.carpath.2024.107604. Epub 2024 Jan 20. Cardiovasc Pathol. 2024. PMID: 38253300 Free article. Review.
Severe noninflammatory degenerative changes (elastic fiber fragmentation, smooth muscle cells death, mucoid extracellular matrix accumulation=MEMA) are observed in the aortic wall of BAV patients, with intrinsic weakness accounting for progressive aneu …
Severe noninflammatory degenerative changes (elastic fiber fragmentation, smooth muscle cells death, mucoid extracellul …
Mechanisms of cardiovascular remodeling in hyperhomocysteinemia.
Steed MM, Tyagi SC. Steed MM, et al. Antioxid Redox Signal. 2011 Oct 1;15(7):1927-43. doi: 10.1089/ars.2010.3721. Epub 2011 Apr 21. Antioxid Redox Signal. 2011. PMID: 21126196 Free PMC article. Review.
In hypertension, an increase in arterial wall thickness and loss of elasticity over time result in an increase in pulse wave velocity, a direct measure of arterial stiffness. This change is reflected in gradual fragmentation and loss of elastin fibers and accumulation of s …
In hypertension, an increase in arterial wall thickness and loss of elasticity over time result in an increase in pulse wave velocity, a dir …
Elastin-elastases and inflamm-aging.
Antonicelli F, Bellon G, Debelle L, Hornebeck W. Antonicelli F, et al. Curr Top Dev Biol. 2007;79:99-155. doi: 10.1016/S0070-2153(06)79005-6. Curr Top Dev Biol. 2007. PMID: 17498549 Review.
Degradation of elastin, the main amorphous component of elastic fibers, by elastases belonging to the serine, metallo, or cysteine families leads to the generation of elastin fragments, designated as elastokines in keeping with their cytokine-like properties. ...In …
Degradation of elastin, the main amorphous component of elastic fibers, by elastases belonging to the serine, metallo, or cysteine fa …
Nitric oxide in the Marfan vasculature: Friend or foe?
Tehrani AY, Ciufolini MA, Bernatchez P. Tehrani AY, et al. Nitric Oxide. 2021 Nov 1;116:27-34. doi: 10.1016/j.niox.2021.08.006. Epub 2021 Aug 31. Nitric Oxide. 2021. PMID: 34478846 Review.
Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in the FBN1 gene, which encodes fibrillin-1, a protein essential for the formation and stabilization of elastic fibers as well as signaling homeostasis. ...However, despite their ability to de …
Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in the FBN1 gene, which encodes fibrillin-1, a protein esse …
The molecular pathogenesis of the Marfan syndrome.
Robinson PN, Booms P. Robinson PN, et al. Cell Mol Life Sci. 2001 Oct;58(11):1698-707. doi: 10.1007/pl00000807. Cell Mol Life Sci. 2001. PMID: 11706995 Review.
The Marfan syndrome (MFS) is an autosomal dominant heritable disorder of connective tissue with highly variable clinical manifestations including aortic dilatation and dissection, ectopia lentis, and a range of skeletal anomalies. Mutations in the gene for fibrillin …
The Marfan syndrome (MFS) is an autosomal dominant heritable disorder of connective tissue with highly variable clinical manifestatio …
Soluble elastin peptides in cardiovascular homeostasis: Foe or ally.
Qin Z. Qin Z. Peptides. 2015 May;67:64-73. doi: 10.1016/j.peptides.2015.03.006. Epub 2015 Mar 17. Peptides. 2015. PMID: 25794852 Review.
Elastin peptides, also known as elastin-derived peptides or elastokines, are soluble polypeptides in blood and tissue. The blood levels of elastin peptides are usually low but can increase during cardiovascular diseases, such as atherosclerosis, aortic aneurysm and …
Elastin peptides, also known as elastin-derived peptides or elastokines, are soluble polypeptides in blood and tissue. The blood leve …
Milk Fat Globule Epidermal Growth Factor VIII Fragment Medin in Age-Associated Arterial Adverse Remodeling and Arterial Disease.
Wang M, McGraw KR, Monticone RE. Wang M, et al. Cells. 2023 Jan 7;12(2):253. doi: 10.3390/cells12020253. Cells. 2023. PMID: 36672188 Free PMC article. Review.
Medin has been reported as the most common amylogenic protein in the upper part of the arterial system, including aortic, temporal, and cerebral arterial walls in the elderly. Medin has a high affinity to elastic fibers and is closely associated with arterial degene …
Medin has been reported as the most common amylogenic protein in the upper part of the arterial system, including aortic, temporal, a …
19 results