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1979 1
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131 results

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Page 1
The complement system and human autoimmune diseases.
Coss SL, Zhou D, Chua GT, Aziz RA, Hoffman RP, Wu YL, Ardoin SP, Atkinson JP, Yu CY. Coss SL, et al. J Autoimmun. 2023 May;137:102979. doi: 10.1016/j.jaut.2022.102979. Epub 2022 Dec 18. J Autoimmun. 2023. PMID: 36535812 Free PMC article. Review.
Genetic deficiencies of early components of the classical complement activation pathway (especially C1q, r, s, and C4) are the strongest monogenic causal factors for the prototypic autoimmune disease systemic lupus erythematosus (SLE), but their prevalence is extrem …
Genetic deficiencies of early components of the classical complement activation pathway (especially C1q, r, s, and C4) are the …
Hereditary and acquired angioedema.
Patel G, Pongracic JA. Patel G, et al. Allergy Asthma Proc. 2019 Nov 1;40(6):441-445. doi: 10.2500/aap.2019.40.4267. Allergy Asthma Proc. 2019. PMID: 31690390 Review.
Hereditary angioedema (HAE) is an autosomal dominant disorder defined by a deficiency of functional C1 esterase inhibitor (C1-INH). Acquired angioedema is due to either consumption (type 1) or inactivation (type 2) of CI-INH. ...A useful test to differentiate HAE from acqu …
Hereditary angioedema (HAE) is an autosomal dominant disorder defined by a deficiency of functional C1 esterase inhibitor (C1-INH). A …
C1q: structure, function, and receptors.
Kishore U, Reid KB. Kishore U, et al. Immunopharmacology. 2000 Aug;49(1-2):159-70. doi: 10.1016/s0162-3109(00)80301-x. Immunopharmacology. 2000. PMID: 10904115 Review.
Although newer candidate receptors like C1qR(p) and CR1 have emerged, full analysis of the C1q-C1q receptor interactions is still at an early stage. In view of the diverse functions that C1q is considered to perform, it has been speculated that several C1q
Although newer candidate receptors like C1qR(p) and CR1 have emerged, full analysis of the C1q-C1q receptor interactions is st …
Immunodeficiency: Complement disorders.
McMurray JC, Schornack BJ, Weskamp AL, Park KJ, Pollock JD, Day WG, Brockshus AT, Beakes DE, Schwartz DJ, Mikita CP, Pittman LM. McMurray JC, et al. Allergy Asthma Proc. 2024 Sep 1;45(5):305-309. doi: 10.2500/aap.2024.45.240050. Allergy Asthma Proc. 2024. PMID: 39294906 Free PMC article. Review.
Classic pathway defects result from deficiencies of complement proteins C1q, C1r, C1s, C2, and C4, and typically manifest with features of systemic lupus erythematosus and infections with encapsulated organisms. ...Deficiencies in factor H and factor I, which …
Classic pathway defects result from deficiencies of complement proteins C1q, C1r, C1s, C2, and C4, and typically manifest with …
Streptococcus pneumoniae interactions with the complement system.
Gil E, Noursadeghi M, Brown JS. Gil E, et al. Front Cell Infect Microbiol. 2022 Jul 28;12:929483. doi: 10.3389/fcimb.2022.929483. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 35967850 Free PMC article. Review.
Host innate and adaptive immunity to infection with Streptococcus pneumoniae is critically dependent on the complement system, demonstrated by the high incidence of invasive S. pneumoniae infection in people with inherited deficiency of complement components. The complemen …
Host innate and adaptive immunity to infection with Streptococcus pneumoniae is critically dependent on the complement system, demonstrated …
Antibody-Dependent Enhancement (ADE) and the role of complement system in disease pathogenesis.
Thomas S, Smatti MK, Ouhtit A, Cyprian FS, Almaslamani MA, Thani AA, Yassine HM. Thomas S, et al. Mol Immunol. 2022 Dec;152:172-182. doi: 10.1016/j.molimm.2022.11.010. Epub 2022 Nov 10. Mol Immunol. 2022. PMID: 36371813 Free PMC article. Review.
Antibody-mediated effector functions are mainly driven by complement activation, and the first complement in the cascade is complement 1q (C1q) which binds to the virus-antibody complex. Reports say that deficiency in circulating plasma levels of C1q, an inde …
Antibody-mediated effector functions are mainly driven by complement activation, and the first complement in the cascade is complement 1q ( …
Monogenic autoimmunity.
Cheng MH, Anderson MS. Cheng MH, et al. Annu Rev Immunol. 2012;30:393-427. doi: 10.1146/annurev-immunol-020711-074953. Epub 2012 Jan 6. Annu Rev Immunol. 2012. PMID: 22224765 Free PMC article. Review.
For example, defects in the clearance of self-antigens and chronic stimulation of type 1 interferons lead to the systemic autoimmunity seen in C1q deficiency, SPENCDI, and AGS. In contrast, disturbances of adaptive immunity, which is built for antigen specificity, t …
For example, defects in the clearance of self-antigens and chronic stimulation of type 1 interferons lead to the systemic autoimmunity seen …
Update on hereditary C1q deficiency: pathophysiology, clinical presentation, genotype and management.
Buso H, Triaille C, Flinn AM, Gennery AR. Buso H, et al. Curr Opin Allergy Clin Immunol. 2024 Dec 1;24(6):427-433. doi: 10.1097/ACI.0000000000001034. Epub 2024 Oct 3. Curr Opin Allergy Clin Immunol. 2024. PMID: 39479952 Review.
The management of patients with C1q deficiency is challenged by the rarity of this condition and the wide clinical variability. ...RECENT FINDINGS: We focus on the concept of C1q deficiency as a bridge between the monogenic form of systemic lupus eryth …
The management of patients with C1q deficiency is challenged by the rarity of this condition and the wide clinical variability …
Acquired C1 Inhibitor Deficiency.
Otani IM, Banerji A. Otani IM, et al. Immunol Allergy Clin North Am. 2017 Aug;37(3):497-511. doi: 10.1016/j.iac.2017.03.002. Epub 2017 May 15. Immunol Allergy Clin North Am. 2017. PMID: 28687105 Review.
Acquired angioedema due to C1-INH deficiency (C1-INH-AAE) can occur when there are acquired (not inherited) deficiencies of C1-INH. A quantitative or functional C1-INH deficiency with negative family history and low C1q is diagnostic of C1-INH-AAE. The …
Acquired angioedema due to C1-INH deficiency (C1-INH-AAE) can occur when there are acquired (not inherited) deficiencies of C1 …
SLE: Novel Postulates for Therapeutic Options.
Hosszu KK, Valentino A, Peerschke EI, Ghebrehiwet B. Hosszu KK, et al. Front Immunol. 2020 Oct 7;11:583853. doi: 10.3389/fimmu.2020.583853. eCollection 2020. Front Immunol. 2020. PMID: 33117397 Free PMC article. Review.
Genetic deficiency in C1q is a strong susceptibility factor for systemic lupus erythematosus (SLE). There are two major hypotheses that potentially explain the role of C1q in SLE. The first postulates that C1q deficiency abrogates apoptotic cell …
Genetic deficiency in C1q is a strong susceptibility factor for systemic lupus erythematosus (SLE). There are two major hypoth …
131 results