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Year Number of Results
2011 2
2016 1
2019 1
2020 2
2021 1
2022 3
2023 3
2024 1

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13 results

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Page 1
Physical Activity and Health in Chronic Kidney Disease.
Wilund KR, Thompson S, Viana JL, Wang AY. Wilund KR, et al. Contrib Nephrol. 2021;199:43-55. doi: 10.1159/000517696. Epub 2021 Aug 3. Contrib Nephrol. 2021. PMID: 34343989 Review.
CKD has profound negative effects on skeletal muscle structure and function that are related to impairments in mitochondrial function, inflammation, oxidative stress, metabolic acidosis, and other uremia-related factors. ...In summary, low physical activity levels i …
CKD has profound negative effects on skeletal muscle structure and function that are related to impairments in mitochondrial function …
Myostatin/Activin Receptor Ligands in Muscle and the Development Status of Attenuating Drugs.
Rodgers BD, Ward CW. Rodgers BD, et al. Endocr Rev. 2022 Mar 9;43(2):329-365. doi: 10.1210/endrev/bnab030. Endocr Rev. 2022. PMID: 34520530 Free PMC article. Review.
As a comorbidity, muscle wasting is associated with different neuromuscular diseases and myopathies, cancer, heart failure, chronic pulmonary and renal diseases, peripheral neuropathies, inflammatory disorders, and, of course, musculoskeletal injuries. ...Each is un …
As a comorbidity, muscle wasting is associated with different neuromuscular diseases and myopathies, cancer, heart failure, chronic p …
Recent Updates on the Genetics of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia.
Kirola L, Mukherjee A, Mutsuddi M. Kirola L, et al. Mol Neurobiol. 2022 Sep;59(9):5673-5694. doi: 10.1007/s12035-022-02934-z. Epub 2022 Jun 30. Mol Neurobiol. 2022. PMID: 35768750 Review.
However, the newly identified genes show higher disease frequencies in combination with known genes that are implicated in pathogenesis, thus indicating probable digenetic/polygenic inheritance models, along with epistatic interactions. Studies suggest that these genes pla …
However, the newly identified genes show higher disease frequencies in combination with known genes that are implicated in pathogenes …
Therapeutic developments for valosin-containing protein mediated multisystem proteinopathy.
Boock V, Roy B, Pfeffer G, Kimonis V. Boock V, et al. Curr Opin Neurol. 2023 Oct 1;36(5):432-440. doi: 10.1097/WCO.0000000000001184. Epub 2023 Aug 30. Curr Opin Neurol. 2023. PMID: 37678339 Review.
PURPOSE OF REVIEW: Missense mutations in valosin-containing protein (VCP) can lead to a multisystem proteinopathy 1 (MSP1) with any combination of limb-girdle distribution inclusion body myopathy (IBM) (present in about 90% of cases), Paget's disease of bone, and frontotem …
PURPOSE OF REVIEW: Missense mutations in valosin-containing protein (VCP) can lead to a multisystem proteinopathy 1 (MSP1) with any combi …
Small molecules targeting different cellular pathologies for the treatment of amyotrophic lateral sclerosis.
Elmansy MF, Reidl CT, Rahaman M, Özdinler PH, Silverman RB. Elmansy MF, et al. Med Res Rev. 2023 Nov;43(6):2260-2302. doi: 10.1002/med.21974. Epub 2023 May 26. Med Res Rev. 2023. PMID: 37243319 Review.
There are no effective cures, albeit three drugs, riluzole, edaravone, and AMX0035 (a combination of sodium phenylbutyrate and taurursodiol), have been approved by the Food and Drug Administration, with limited improvement in patients. ...Since the disease is very heteroge …
There are no effective cures, albeit three drugs, riluzole, edaravone, and AMX0035 (a combination of sodium phenylbutyrate and taurur …
Targeting autophagy, oxidative stress, and ER stress for neurodegenerative disease treatment.
Esmaeili Y, Yarjanli Z, Pakniya F, Bidram E, Łos MJ, Eshraghi M, Klionsky DJ, Ghavami S, Zarrabi A. Esmaeili Y, et al. J Control Release. 2022 May;345:147-175. doi: 10.1016/j.jconrel.2022.03.001. Epub 2022 Mar 3. J Control Release. 2022. PMID: 35248646 Review.
Protein homeostasis is a vital process for cell function and, therefore, disruption of the molecular mechanisms involved in this process, such as autophagy, may contribute to neurodegenerative diseases (NDs). Apart from autophagy disruption, excess oxidative stress …
Protein homeostasis is a vital process for cell function and, therefore, disruption of the molecular mechanisms involved in this process, su …
Protective potential of thymoquinone against cadmium, arsenic, and lead toxicity: A short review with emphasis on oxidative pathways.
Ghasemi F, Nili-Ahmadabadi A, Omidifar N, Nili-Ahmadabadi M. Ghasemi F, et al. J Appl Toxicol. 2023 Dec;43(12):1764-1777. doi: 10.1002/jat.4459. Epub 2023 Mar 22. J Appl Toxicol. 2023. PMID: 36872630 Review.
Their extensive use has increased human susceptibility to different chronic diseases. Toxic metal exposure, especially cadmium, arsenic, and lead, causes oxidative damages, mitochondrial dysfunction, and genetic and epigenetic modifications. ...Scientific dat …
Their extensive use has increased human susceptibility to different chronic diseases. Toxic metal exposure, especially cadmium, arsen …
Maintaining the balance of TDP-43, mitochondria, and autophagy: a promising therapeutic strategy for neurodegenerative diseases.
Huang C, Yan S, Zhang Z. Huang C, et al. Transl Neurodegener. 2020 Oct 30;9(1):40. doi: 10.1186/s40035-020-00219-w. Transl Neurodegener. 2020. PMID: 33126923 Free PMC article. Review.
Importantly, TDP-43 is associated with a variety of neurodegenerative diseases, including amyotrophic lateral sclerosis, frontotemporal dementia and Alzheimer's disease, which are characterized by abnormal phosphorylation, ubiquitination, lysis or nuclear dep …
Importantly, TDP-43 is associated with a variety of neurodegenerative diseases, including amyotrophic lateral sclerosis, front …
Influence of aging on membrane permeability transition in brain mitochondria.
Toman J, Fiskum G. Toman J, et al. J Bioenerg Biomembr. 2011 Feb;43(1):3-10. doi: 10.1007/s10863-011-9337-8. J Bioenerg Biomembr. 2011. PMID: 21311961 Free PMC article. Review.
Opening of the permeability transition pore (PTP) by a combination of abnormally elevated intramitochondrial Ca2+ and oxidative stress induces the collapse of transmembrane ion gradients, resulting in membrane depolarization and uncoupling of oxidative pho …
Opening of the permeability transition pore (PTP) by a combination of abnormally elevated intramitochondrial Ca2+ and oxidative …
Peroxisome proliferator-activated receptors in cardiac energy metabolism and cardiovascular disease.
Ajith TA, Jayakumar TG. Ajith TA, et al. Clin Exp Pharmacol Physiol. 2016 Jul;43(7):649-58. doi: 10.1111/1440-1681.12579. Clin Exp Pharmacol Physiol. 2016. PMID: 27115677 Review.
Cardiomyocytes mainly depend on energy produced from the oxidation of fatty acids and mitochondrial oxidative phosphorylation. Shortage of energy or excessive fat accumulation can lead to cardiac disorders. ...Various synthetic ligands of PPAR-alpha and beta/ …
Cardiomyocytes mainly depend on energy produced from the oxidation of fatty acids and mitochondrial oxidative phosphorylati …
13 results