Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1947 2
1948 4
1962 3
1963 493
1964 767
1965 629
1966 717
1967 954
1968 1109
1969 1319
1970 1384
1971 1696
1972 1692
1973 1702
1974 1994
1975 1785
1976 1848
1977 1648
1978 2013
1979 2145
1980 2325
1981 2607
1982 2589
1983 3160
1984 3506
1985 3650
1986 4090
1987 6021
1988 9060
1989 11053
1990 11747
1991 12293
1992 12934
1993 13734
1994 15079
1995 15533
1996 16637
1997 18283
1998 18727
1999 20298
2000 22358
2001 23448
2002 25011
2003 27637
2004 29331
2005 30979
2006 32622
2007 33950
2008 34268
2009 34546
2010 36394
2011 38847
2012 41415
2013 44350
2014 46842
2015 48132
2016 50419
2017 50961
2018 47695
2019 46288
2020 54936
2021 56993
2022 50561
2023 47364
2024 16508

Text availability

Article attribute

Article type

Publication date

Search Results

1,101,408 results

Results by year

Filters applied: . Clear all
Page 1
Epigenetics in Health and Disease.
Zhang L, Lu Q, Chang C. Zhang L, et al. Adv Exp Med Biol. 2020;1253:3-55. doi: 10.1007/978-981-15-3449-2_1. Adv Exp Med Biol. 2020. PMID: 32445090 Review.
Disruption of gene expression patterns which are governed by epigenetics can result in autoimmune diseases, cancers, and various other maladies. Mechanisms of epigenetics include DNA methylation (and demethylation), histone modifications, and non-coding RNAs such as microR …
Disruption of gene expression patterns which are governed by epigenetics can result in autoimmune diseases, cancers, and various othe …
Current understanding of the human microbiome.
Gilbert JA, Blaser MJ, Caporaso JG, Jansson JK, Lynch SV, Knight R. Gilbert JA, et al. Nat Med. 2018 Apr 10;24(4):392-400. doi: 10.1038/nm.4517. Nat Med. 2018. PMID: 29634682 Free PMC article. Review.
Our understanding of the link between the human microbiome and disease, including obesity, inflammatory bowel disease, arthritis and autism, is rapidly expanding. Improvements in the throughput and accuracy of DNA sequencing of the genomes of microbial communities t …
Our understanding of the link between the human microbiome and disease, including obesity, inflammatory bowel disease, arthrit …
Social conditions as fundamental causes of disease.
Link BG, Phelan J. Link BG, et al. J Health Soc Behav. 1995;Spec No:80-94. J Health Soc Behav. 1995. PMID: 7560851 Free article. Review.
Over the last several decades, epidemiological studies have been enormously successful in identifying risk factors for major diseases. However, most of this research has focused attention on risk factors that are relatively proximal causes of disease such as diet, c …
Over the last several decades, epidemiological studies have been enormously successful in identifying risk factors for major diseases …
The exposome and health: Where chemistry meets biology.
Vermeulen R, Schymanski EL, Barabási AL, Miller GW. Vermeulen R, et al. Science. 2020 Jan 24;367(6476):392-396. doi: 10.1126/science.aay3164. Science. 2020. PMID: 31974245 Free PMC article. Review.
Despite extensive evidence showing that exposure to specific chemicals can lead to disease, current research approaches and regulatory policies fail to address the chemical complexity of our world. ...Given the increased recognition of the dominant role that nongenetic fac …
Despite extensive evidence showing that exposure to specific chemicals can lead to disease, current research approaches and regulator …
Transcriptional regulation and its misregulation in disease.
Lee TI, Young RA. Lee TI, et al. Cell. 2013 Mar 14;152(6):1237-51. doi: 10.1016/j.cell.2013.02.014. Cell. 2013. PMID: 23498934 Free PMC article. Review.
Misregulation of these gene expression programs can cause a broad range of diseases. Here, we review recent advances in our understanding of transcriptional regulation and discuss how these have provided new insights into transcriptional misregulation in disease....
Misregulation of these gene expression programs can cause a broad range of diseases. Here, we review recent advances in our understan …
An Expanded View of Complex Traits: From Polygenic to Omnigenic.
Boyle EA, Li YI, Pritchard JK. Boyle EA, et al. Cell. 2017 Jun 15;169(7):1177-1186. doi: 10.1016/j.cell.2017.05.038. Cell. 2017. PMID: 28622505 Free PMC article. Review.
A central goal of genetics is to understand the links between genetic variation and disease. Intuitively, one might expect disease-causing variants to cluster into key pathways that drive disease etiology. But for complex traits, association signals tend to b …
A central goal of genetics is to understand the links between genetic variation and disease. Intuitively, one might expect disease …
Cell death pathways: intricate connections and disease implications.
Kist M, Vucic D. Kist M, et al. EMBO J. 2021 Mar 1;40(5):e106700. doi: 10.15252/embj.2020106700. Epub 2021 Jan 13. EMBO J. 2021. PMID: 33439509 Free PMC article. Review.
Finally, a number of cell death regulators are implicated in human diseases and represent attractive therapeutic targets. Therefore, better understanding of physiological and mechanistic aspects of cell death signaling should yield improved reagents for addressing unmet me …
Finally, a number of cell death regulators are implicated in human diseases and represent attractive therapeutic targets. Therefore, …
Necroptosis in the Pathophysiology of Disease.
Khoury MK, Gupta K, Franco SR, Liu B. Khoury MK, et al. Am J Pathol. 2020 Feb;190(2):272-285. doi: 10.1016/j.ajpath.2019.10.012. Epub 2019 Nov 26. Am J Pathol. 2020. PMID: 31783008 Free PMC article. Review.
In this review, we provide an understanding of necroptotic cell-death and highlight diseases in which necroptosis has been found to play a role. We also discuss the inhibitors of necroptosis and the ways these inhibitors have been used in preclinical models of diseases …
In this review, we provide an understanding of necroptotic cell-death and highlight diseases in which necroptosis has been found to p …
Mitochondrial DNA Integrity: Role in Health and Disease.
Sharma P, Sampath H. Sharma P, et al. Cells. 2019 Jan 29;8(2):100. doi: 10.3390/cells8020100. Cells. 2019. PMID: 30700008 Free PMC article. Review.
Damage to mitochondrial DNA (mtDNA) and loss of mitochondrial genome integrity is increasingly understood to play a role in the development of both severe early-onset maladies and chronic age-related diseases. In this article, we review the processes by which mtDNA integri …
Damage to mitochondrial DNA (mtDNA) and loss of mitochondrial genome integrity is increasingly understood to play a role in the development …
Human Organoids: Tools for Understanding Biology and Treating Diseases.
Schutgens F, Clevers H. Schutgens F, et al. Annu Rev Pathol. 2020 Jan 24;15:211-234. doi: 10.1146/annurev-pathmechdis-012419-032611. Epub 2019 Sep 24. Annu Rev Pathol. 2020. PMID: 31550983 Review.
Organoids derived from adult stem cells exploit the tissue regeneration process that is driven by these cells, and they can be established directly from the healthy or diseased epithelium of many organs. Organoids are amenable to any experimental approach that has been dev …
Organoids derived from adult stem cells exploit the tissue regeneration process that is driven by these cells, and they can be established d …
1,101,408 results
You have reached the last available page of results. Please see the User Guide for more information.