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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1963 19
1964 54
1965 45
1966 62
1967 180
1968 312
1969 464
1970 525
1971 661
1972 754
1973 889
1974 990
1975 913
1976 905
1977 838
1978 983
1979 1086
1980 1156
1981 1191
1982 1455
1983 1709
1984 1965
1985 2114
1986 2092
1987 2421
1988 3142
1989 4070
1990 4750
1991 4774
1992 5038
1993 5657
1994 5954
1995 6308
1996 6827
1997 7158
1998 7734
1999 8436
2000 9702
2001 10830
2002 12225
2003 13429
2004 14440
2005 14969
2006 16199
2007 16987
2008 17599
2009 18042
2010 19344
2011 20565
2012 21953
2013 22354
2014 23406
2015 23734
2016 24388
2017 24452
2018 23796
2019 23229
2020 27143
2021 27592
2022 21953
2023 20127
2024 9425

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522,195 results

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Page 1
Cytochrome P450 Enzymes and Drug Metabolism in Humans.
Zhao M, Ma J, Li M, Zhang Y, Jiang B, Zhao X, Huai C, Shen L, Zhang N, He L, Qin S. Zhao M, et al. Int J Mol Sci. 2021 Nov 26;22(23):12808. doi: 10.3390/ijms222312808. Int J Mol Sci. 2021. PMID: 34884615 Free PMC article. Review.
In addition to the basic metabolic effects for elimination, CYPs are also capable of affecting drug responses by influencing drug action, safety, bioavailability, and drug resistance through metabolism, in both metabolic organs and …
In addition to the basic metabolic effects for elimination, CYPs are also capable of affecting drug responses by influe …
Drug Metabolism in the Liver.
Almazroo OA, Miah MK, Venkataramanan R. Almazroo OA, et al. Clin Liver Dis. 2017 Feb;21(1):1-20. doi: 10.1016/j.cld.2016.08.001. Epub 2016 Oct 15. Clin Liver Dis. 2017. PMID: 27842765 Review.
Phase II drug metabolism is a conjugation reaction. Phase III refers to transporter-mediated elimination of drug and/or metabolites from body normally via liver, gut, kidney, or lung. This review presents basic information on drug-metabolizing e …
Phase II drug metabolism is a conjugation reaction. Phase III refers to transporter-mediated elimination of drug and/or …
Regulation and metabolic functions of mTORC1 and mTORC2.
Szwed A, Kim E, Jacinto E. Szwed A, et al. Physiol Rev. 2021 Jul 1;101(3):1371-1426. doi: 10.1152/physrev.00026.2020. Epub 2021 Feb 18. Physiol Rev. 2021. PMID: 33599151 Free PMC article. Review.
Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and proliferation. The uptake of nutrients from the environment and their intracellular metabolism is a highly controlled process that involves cross talk between growth signaling and …
Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and proliferation. The uptake of nutrients from the …
Developmental Changes in Pharmacokinetics and Pharmacodynamics.
van den Anker J, Reed MD, Allegaert K, Kearns GL. van den Anker J, et al. J Clin Pharmacol. 2018 Oct;58 Suppl 10:S10-S25. doi: 10.1002/jcph.1284. J Clin Pharmacol. 2018. PMID: 30248190 Review.
Effective drug therapy to optimally influence disease requires an understanding of a drug's pharmacokinetic, pharmacodynamic, and pharmacogenomic interrelationships. ...What is known about the influence of maturation on the processes of drug absorption, distr …
Effective drug therapy to optimally influence disease requires an understanding of a drug's pharmacokinetic, pharmacodynamic, …
Adipocyte and lipid metabolism in cancer drug resistance.
Cao Y. Cao Y. J Clin Invest. 2019 Jul 2;129(8):3006-3017. doi: 10.1172/JCI127201. eCollection 2019 Jul 2. J Clin Invest. 2019. PMID: 31264969 Free PMC article. Review.
While cancer cells' dependence on glycolysis for energy production is well studied, the roles of adipocytes and lipid metabolic reprogramming in supporting cancer growth, metastasis, and drug responses are less understood. This Review focuses on emerging mech …
While cancer cells' dependence on glycolysis for energy production is well studied, the roles of adipocytes and lipid metabolic repro …
L-carnitine--metabolic functions and meaning in humans life.
Pekala J, Patkowska-Sokoła B, Bodkowski R, Jamroz D, Nowakowski P, Lochyński S, Librowski T. Pekala J, et al. Curr Drug Metab. 2011 Sep;12(7):667-78. doi: 10.2174/138920011796504536. Curr Drug Metab. 2011. PMID: 21561431 Review.
L-Carnitine is an endogenous molecule involved in fatty acid metabolism, biosynthesized within the human body using amino acids: L-lysine and L-methionine, as substrates. ...Further research is warranted in order to evaluate the biochemical, pharmacological, and physiologi …
L-Carnitine is an endogenous molecule involved in fatty acid metabolism, biosynthesized within the human body using amino acids: L-ly …
Metabolic reprogramming in triple-negative breast cancer.
Wang Z, Jiang Q, Dong C. Wang Z, et al. Cancer Biol Med. 2020 Feb 15;17(1):44-59. doi: 10.20892/j.issn.2095-3941.2019.0210. Cancer Biol Med. 2020. PMID: 32296576 Free PMC article. Review.
Understanding the mechanisms of metabolic remodeling may guide the design of metabolic strategies for the effective intervention of TNBC. Here, we review the metabolic reprogramming of glycolysis, oxidative phosphorylation, amino acid metabolism, lipid …
Understanding the mechanisms of metabolic remodeling may guide the design of metabolic strategies for the effective interventi …
Succinylation Links Metabolism to Protein Functions.
Yang Y, Gibson GE. Yang Y, et al. Neurochem Res. 2019 Oct;44(10):2346-2359. doi: 10.1007/s11064-019-02780-x. Epub 2019 Mar 22. Neurochem Res. 2019. PMID: 30903449 Free PMC article. Review.
The few completed studies demonstrate that succinylation alters rates of enzymes and pathways, especially mitochondrial metabolic pathways. Thus, succinylation provides an elegant and efficient mechanism to coordinate metabolism and signaling by utilizing metabol …
The few completed studies demonstrate that succinylation alters rates of enzymes and pathways, especially mitochondrial metabolic pat …
Understanding drug-drug interaction and pharmacogenomic changes in pharmacokinetics for metabolized drugs.
Benet LZ, Bowman CM, Koleske ML, Rinaldi CL, Sodhi JK. Benet LZ, et al. J Pharmacokinet Pharmacodyn. 2019 Apr;46(2):155-163. doi: 10.1007/s10928-019-09626-7. Epub 2019 Mar 25. J Pharmacokinet Pharmacodyn. 2019. PMID: 30911879 Free PMC article. Review.
Here we characterize and summarize the pharmacokinetic changes for metabolized drugs when drug-drug interactions and pharmacogenomic variance are observed. ...The characteristics of drugs based on the ratios of area under the curve, maximum concentration and …
Here we characterize and summarize the pharmacokinetic changes for metabolized drugs when drug-drug interactions and ph …
The signaling pathways and therapeutic potential of itaconate to alleviate inflammation and oxidative stress in inflammatory diseases.
Shi X, Zhou H, Wei J, Mo W, Li Q, Lv X. Shi X, et al. Redox Biol. 2022 Dec;58:102553. doi: 10.1016/j.redox.2022.102553. Epub 2022 Nov 23. Redox Biol. 2022. PMID: 36459716 Free PMC article. Review.
Endogenous small molecules are metabolic regulators of cell function. Itaconate is a key molecule that accumulates in cells when the Krebs cycle is disrupted. ...Itaconate is also an important bridge among metabolism, inflammation, oxidative stress, and the immune …
Endogenous small molecules are metabolic regulators of cell function. Itaconate is a key molecule that accumulates in cells when the …
522,195 results
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