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1986
2025

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1986 1
1989 3
1992 2
1993 2
1995 6
1996 3
1997 5
1998 6
1999 5
2000 3
2001 1
2002 7
2003 5
2004 3
2005 1
2006 5
2007 3
2008 3
2009 2
2010 1
2011 1
2012 8
2013 6
2014 5
2015 1
2016 3
2017 5
2018 4
2019 3
2020 5
2021 3
2022 2
2023 3
2025 0

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108 results

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Page 1
Alzheimer's disease associated with Down syndrome: a genetic form of dementia.
Fortea J, Zaman SH, Hartley S, Rafii MS, Head E, Carmona-Iragui M. Fortea J, et al. Lancet Neurol. 2021 Nov;20(11):930-942. doi: 10.1016/S1474-4422(21)00245-3. Lancet Neurol. 2021. PMID: 34687637 Free PMC article. Review.
Adults with Down syndrome develop the neuropathological hallmarks of Alzheimer's disease and are at very high risk of developing early-onset dementia, which is now the leading cause of death in this population. ...In people with Down syndrome, fluid an …
Adults with Down syndrome develop the neuropathological hallmarks of Alzheimer's disease and are at very high risk of developi …
Alzheimer's Disease: An Updated Overview of Its Genetics.
Andrade-Guerrero J, Santiago-Balmaseda A, Jeronimo-Aguilar P, Vargas-Rodríguez I, Cadena-Suárez AR, Sánchez-Garibay C, Pozo-Molina G, Méndez-Catalá CF, Cardenas-Aguayo MD, Diaz-Cintra S, Pacheco-Herrero M, Luna-Muñoz J, Soto-Rojas LO. Andrade-Guerrero J, et al. Int J Mol Sci. 2023 Feb 13;24(4):3754. doi: 10.3390/ijms24043754. Int J Mol Sci. 2023. PMID: 36835161 Free PMC article. Review.
Alzheimer's disease (AD) is the most common neurodegenerative disease in the world. It is classified as familial and sporadic. The dominant familial or autosomal presentation represents 1-5% of the total number of cases. ...
Alzheimer's disease (AD) is the most common neurodegenerative disease in the world. It is classified as familial and sp
Alzheimer's disease.
Blennow K, de Leon MJ, Zetterberg H. Blennow K, et al. Lancet. 2006 Jul 29;368(9533):387-403. doi: 10.1016/S0140-6736(06)69113-7. Lancet. 2006. PMID: 16876668 Review.
However, as our knowledge increases so does our appreciation for the pathogenic complexity of the disorder. Familial Alzheimer's disease is a very rare autosomal dominant disease with early onset, caused by mutations in the amyloid …
However, as our knowledge increases so does our appreciation for the pathogenic complexity of the disorder. Familial Alzheimer's d
Molecular genetics of early-onset Alzheimer's disease revisited.
Cacace R, Sleegers K, Van Broeckhoven C. Cacace R, et al. Alzheimers Dement. 2016 Jun;12(6):733-48. doi: 10.1016/j.jalz.2016.01.012. Epub 2016 Mar 24. Alzheimers Dement. 2016. PMID: 27016693 Free article. Review.
As the discovery of the Alzheimer's disease (AD) genes, APP, PSEN1, and PSEN2, in families with autosomal dominant early-onset AD (EOAD), gene discovery in familial EOAD came more or less to a standstill. ...Here, we aimed at summarizing …
As the discovery of the Alzheimer's disease (AD) genes, APP, PSEN1, and PSEN2, in families with autosomal dominant
Alzheimer's Disease Including Focal Presentations.
Villain N, Dubois B. Villain N, et al. Semin Neurol. 2019 Apr;39(2):213-226. doi: 10.1055/s-0039-1681041. Epub 2019 Mar 29. Semin Neurol. 2019. PMID: 30925614 Free article. Review.
Alzheimer's disease (AD) is the commonest neurodegenerative disease and the most frequent cause of dementia. ...Current epidemiological data, which mostly rely on biomarker-undetermined AD cases, have highlighted ApoE4 and age as the main risk factors. Rare
Alzheimer's disease (AD) is the commonest neurodegenerative disease and the most frequent cause of dementia. ...Current
Genetics of dementia.
Loy CT, Schofield PR, Turner AM, Kwok JB. Loy CT, et al. Lancet. 2014 Mar 1;383(9919):828-40. doi: 10.1016/S0140-6736(13)60630-3. Epub 2013 Aug 6. Lancet. 2014. PMID: 23927914 Review.
A small proportion of families have an autosomal dominant family history of early-onset dementia, which is often due to mendelian disease, caused by a mutation in one of the dementia genes. ...In this Review, we focus on the evidence for, and th …
A small proportion of families have an autosomal dominant family history of early-onset dementia, which is often …
Frontotemporal dementia.
Perry DC, Miller BL. Perry DC, et al. Semin Neurol. 2013 Sep;33(4):336-41. doi: 10.1055/s-0033-1359316. Epub 2013 Nov 14. Semin Neurol. 2013. PMID: 24234354 Review.
Frontotemporal dementia (FTD) encompasses several clinical syndromes that involve a progressive change in behavior and/or language; it is more common than Alzheimer's disease in early-onset dementia under the age of 60 years. In the behavioral variant …
Frontotemporal dementia (FTD) encompasses several clinical syndromes that involve a progressive change in behavior and/or language; it is mo …
The dementias.
Ritchie K, Lovestone S. Ritchie K, et al. Lancet. 2002 Nov 30;360(9347):1759-66. doi: 10.1016/S0140-6736(02)11667-9. Lancet. 2002. PMID: 12480441 Review.
Different forms of dementia are now distinguished-Alzheimer's disease, dementia with Lewy bodies, frontotemporal dementia, and dementia secondary to disease, such as AIDS dementia. ...Molecular diagnostic testing and genetic counselling for families with a
Different forms of dementia are now distinguished-Alzheimer's disease, dementia with Lewy bodies, frontotemporal dementia, and …
Amyloid precursor protein gene mutations responsible for early-onset autosomal dominant Alzheimer's disease.
Kowalska A. Kowalska A. Folia Neuropathol. 2003;41(1):35-40. Folia Neuropathol. 2003. PMID: 12862394 Review.
According to the "amyloid cascade hypothesis", the accumulation of A beta peptides in the brain is a primary event in the pathogenesis of Alzheimer's disease (AD). Other pathological features (neurofibrillary tangles, neuronal damage and cell death) are regarded as …
According to the "amyloid cascade hypothesis", the accumulation of A beta peptides in the brain is a primary event in the pathogenesis of …
Early-onset Alzheimer's disease: nonamnestic subtypes and type 2 AD.
Mendez MF. Mendez MF. Arch Med Res. 2012 Nov;43(8):677-85. doi: 10.1016/j.arcmed.2012.11.009. Epub 2012 Nov 21. Arch Med Res. 2012. PMID: 23178565 Free PMC article. Review.
Patients with Alzheimer's disease (AD), the most prevalent neurodegenerative dementia, are usually elderly; however, 4-5% develop early-onset AD (EOAD) with onset before age 65. Most EOAD is sporadic, but about 5% of patients with EOAD have an autos
Patients with Alzheimer's disease (AD), the most prevalent neurodegenerative dementia, are usually elderly; however, 4-5% deve …
108 results