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1963
2025

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1963 14
1964 41
1965 13
1966 12
1967 20
1968 42
1969 62
1970 65
1971 52
1972 80
1973 72
1974 72
1975 75
1976 68
1977 47
1978 51
1979 59
1980 68
1981 81
1982 76
1983 87
1984 65
1985 82
1986 69
1987 100
1988 148
1989 168
1990 242
1991 198
1992 181
1993 223
1994 267
1995 328
1996 262
1997 312
1998 310
1999 330
2000 377
2001 404
2002 458
2003 415
2004 514
2005 565
2006 570
2007 555
2008 630
2009 564
2010 616
2011 680
2012 677
2013 774
2014 938
2015 977
2016 984
2017 891
2018 873
2019 854
2020 992
2021 983
2022 984
2023 1008
2024 875
2025 53

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20,931 results

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Page 1
Molecular and cellular mechanisms of liver fibrosis and its regression.
Kisseleva T, Brenner D. Kisseleva T, et al. Nat Rev Gastroenterol Hepatol. 2021 Mar;18(3):151-166. doi: 10.1038/s41575-020-00372-7. Epub 2020 Oct 30. Nat Rev Gastroenterol Hepatol. 2021. PMID: 33128017 Review.
Chronic liver injury leads to liver inflammation and fibrosis, through which activated myofibroblasts in the liver secrete extracellular matrix proteins that generate the fibrous scar. ...Understanding the mechanisms of liver fibrosis reg …
Chronic liver injury leads to liver inflammation and fibrosis, through which activated myofibroblasts in the liver
Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues.
Parola M, Pinzani M. Parola M, et al. Mol Aspects Med. 2019 Feb;65:37-55. doi: 10.1016/j.mam.2018.09.002. Epub 2018 Sep 13. Mol Aspects Med. 2019. PMID: 30213667 Free article. Review.
Liver fibrogenesis, is a dynamic, highly integrated molecular, cellular and tissue process responsible for driving the excess accumulation of extracellular matrix (ECM) components (i.e., liver fibrosis) sustained by an eterogeneous population of hepatic
Liver fibrogenesis, is a dynamic, highly integrated molecular, cellular and tissue process responsible for driving the excess accumul
Mechanisms of hepatic stellate cell activation.
Tsuchida T, Friedman SL. Tsuchida T, et al. Nat Rev Gastroenterol Hepatol. 2017 Jul;14(7):397-411. doi: 10.1038/nrgastro.2017.38. Epub 2017 May 10. Nat Rev Gastroenterol Hepatol. 2017. PMID: 28487545 Review.
Hepatic fibrosis is a dynamic process characterized by the net accumulation of extracellular matrix resulting from chronic liver injury of any aetiology, including viral infection, alcoholic liver disease and NASH. Activation of hepatic stellate
Hepatic fibrosis is a dynamic process characterized by the net accumulation of extracellular matrix resulting from chronic
TGF-beta/SMAD Pathway and Its Regulation in Hepatic Fibrosis.
Xu F, Liu C, Zhou D, Zhang L. Xu F, et al. J Histochem Cytochem. 2016 Mar;64(3):157-67. doi: 10.1369/0022155415627681. Epub 2016 Jan 8. J Histochem Cytochem. 2016. PMID: 26747705 Free PMC article. Review.
SMAD proteins have been studied extensively as pivotal intracellular effectors of TGF-beta1, acting as transcription factors. In the context of hepatic fibrosis, SMAD3 and SMAD4 are pro-fibrotic, whereas SMAD2 and SMAD7 are protective. ...In this review, we focus on …
SMAD proteins have been studied extensively as pivotal intracellular effectors of TGF-beta1, acting as transcription factors. In the context …
Congenital hepatic fibrosis: case report and review of literature.
Hasbaoui BE, Rifai Z, Saghir S, Ayad A, Lamalmi N, Abilkassem R, Agadr A. Hasbaoui BE, et al. Pan Afr Med J. 2021 Feb 18;38:188. doi: 10.11604/pamj.2021.38.188.27941. eCollection 2021. Pan Afr Med J. 2021. PMID: 33995794 Free PMC article. Review.
Congenital hepatic fibrosis (CHF) is a rare autosomal recessive disease derived from biliary dysgenesis secondary to ductal plate malformation; it often coexists with Caroli's disease, von Meyenburg complexes, autosomal dominant polycystic kidney disease (ADPKD), an …
Congenital hepatic fibrosis (CHF) is a rare autosomal recessive disease derived from biliary dysgenesis secondary to ductal pl …
Cellular and Molecular Mechanisms Underlying Liver Fibrosis Regression.
Caligiuri A, Gentilini A, Pastore M, Gitto S, Marra F. Caligiuri A, et al. Cells. 2021 Oct 15;10(10):2759. doi: 10.3390/cells10102759. Cells. 2021. PMID: 34685739 Free PMC article. Review.
Chronic liver injury of different etiologies may result in hepatic fibrosis, a scar formation process consisting in altered deposition of extracellular matrix. Progression of fibrosis can lead to impaired liver architecture and function, resulti …
Chronic liver injury of different etiologies may result in hepatic fibrosis, a scar formation process consisting in alt …
Hepatic fibrosis 2022: Unmet needs and a blueprint for the future.
Friedman SL, Pinzani M. Friedman SL, et al. Hepatology. 2022 Feb;75(2):473-488. doi: 10.1002/hep.32285. Epub 2022 Jan 11. Hepatology. 2022. PMID: 34923653 Review.
Steady progress over four decades toward understanding the pathogenesis and clinical consequences of hepatic fibrosis has led to the expectation of effective antifibrotic drugs, yet none has been approved. ...Thus, there is an exigent need to clarify the cellular an …
Steady progress over four decades toward understanding the pathogenesis and clinical consequences of hepatic fibrosis has led …
Pathogenesis of liver fibrosis.
Hernandez-Gea V, Friedman SL. Hernandez-Gea V, et al. Annu Rev Pathol. 2011;6:425-56. doi: 10.1146/annurev-pathol-011110-130246. Annu Rev Pathol. 2011. PMID: 21073339 Review.
Liver fibrosis is a major cause of morbidity and mortality worldwide due to chronic viral hepatitis and, more recently, from fatty liver disease associated with obesity. Hepatic stellate cell activation represents a critical event in fibrosis be
Liver fibrosis is a major cause of morbidity and mortality worldwide due to chronic viral hepatitis and, more recently, from f
Mesenchymal stromal cells in hepatic fibrosis/cirrhosis: from pathogenesis to treatment.
Yang X, Li Q, Liu W, Zong C, Wei L, Shi Y, Han Z. Yang X, et al. Cell Mol Immunol. 2023 Jun;20(6):583-599. doi: 10.1038/s41423-023-00983-5. Epub 2023 Feb 24. Cell Mol Immunol. 2023. PMID: 36823236 Free PMC article. Review.
Hepatic fibrosis/cirrhosis is a significant health burden worldwide, resulting in liver failure or hepatocellular carcinoma (HCC) and accounting for many deaths each year. The pathogenesis of hepatic fibrosis/cirrhosis is very comp
Hepatic fibrosis/cirrhosis is a significant health burden worldwide, resulting in liver failure or hepatocellula
Hepatic stellate cell senescence in liver fibrosis: Characteristics, mechanisms and perspectives.
Zhang M, Serna-Salas S, Damba T, Borghesan M, Demaria M, Moshage H. Zhang M, et al. Mech Ageing Dev. 2021 Oct;199:111572. doi: 10.1016/j.mad.2021.111572. Epub 2021 Sep 16. Mech Ageing Dev. 2021. PMID: 34536446 Free article. Review.
Senescent hepatic stellate cells were identified in liver fibrosis. Senescent hepatic stellate cells display decreased collagen production and proliferation. Therefore, induction of senescence could be a protective mechanism against progression of l
Senescent hepatic stellate cells were identified in liver fibrosis. Senescent hepatic stellate cells display dec …
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