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Towards Point-of-Care Heart Failure Diagnostic Platforms: BNP and NT-proBNP Biosensors.
Alawieh H, Chemaly TE, Alam S, Khraiche M. Alawieh H, et al. Sensors (Basel). 2019 Nov 16;19(22):5003. doi: 10.3390/s19225003. Sensors (Basel). 2019. PMID: 31744130 Free PMC article. Review.
Natriuretic neurohormone peptides, B-type natriuretic peptide (BNP) and N-terminal prohormone of BNP (NT-proBNP), are among the most promising biomarkers for clinical use. Remarkably, they result in an increased diagnostic accuracy of around 80% owing to the …
Natriuretic neurohormone peptides, B-type natriuretic peptide (BNP) and N-terminal prohormone of BNP (NT-proBNP), are among th …
Novel biomarkers in acute heart failure: MR-pro-adrenomedullin.
Peacock WF. Peacock WF. Clin Chem Lab Med. 2014 Oct;52(10):1433-5. doi: 10.1515/cclm-2014-0222. Clin Chem Lab Med. 2014. PMID: 24756062 Free article. Review.
ADM expression occurs in many tissues and organ systems, including cardiovascular, renal, pulmonary, cerebrovascular, gastrointestinal, and endocrine tissues where it acts as a circulating hormone and a local autocrine and paracrine hormone. ADM plasma concentrations
ADM expression occurs in many tissues and organ systems, including cardiovascular, renal, pulmonary, cerebrovascular, gastrointestinal, and …
Current biochemistry, molecular biology, and clinical relevance of natriuretic peptides.
Nishikimi T, Kuwahara K, Nakao K. Nishikimi T, et al. J Cardiol. 2011 Mar;57(2):131-40. doi: 10.1016/j.jjcc.2011.01.002. Epub 2011 Feb 5. J Cardiol. 2011. PMID: 21296556 Free article. Review.
By contrast, CNP is mainly expressed in the central nervous system, bone and vasculature. Plasma concentrations of both ANP and BNP are elevated in patients with cardiovascular disease, though the magnitude of the increase in BNP is usually greater than the incre
By contrast, CNP is mainly expressed in the central nervous system, bone and vasculature. Plasma concentrations of both ANP and BNP a …
Clinical pharmacology of levosimendan.
Antila S, Sundberg S, Lehtonen LA. Antila S, et al. Clin Pharmacokinet. 2007;46(7):535-52. doi: 10.2165/00003088-200746070-00001. Clin Pharmacokinet. 2007. PMID: 17596101 Review.
Despite an improvement in ventricular function, levosimendan does not increase myocardial oxygen uptake significantly. An increase in coronary blood flow and a reduction in coronary vascular resistance have been observed. ...The effects of a 24-hour levosimen …
Despite an improvement in ventricular function, levosimendan does not increase myocardial oxygen uptake significantly. An increase
N-terminal prohormone B-type natriuretic peptide and cardiovascular risk in stable coronary artery disease: a meta-analysis of nine prospective studies.
Wei G, Yaqi R, Ningfu W, Xuwei H. Wei G, et al. Rev Cardiovasc Med. 2013;14(2-4):e92-8. doi: 10.3909/ricm0644. Rev Cardiovasc Med. 2013. PMID: 24448259 Review.
In a subanalysis grouped by the median value, per 1 standard deviation increase or per 1000 pg/mL increase of NT-proBNP, the overall effect also showed that poor prognosis was significantly increased with the elevation of NT-proBNP
In a subanalysis grouped by the median value, per 1 standard deviation increase or per 1000 pg/mL increase of NT-pro
Advances in congestive heart failure management in the intensive care unit: B-type natriuretic peptides in evaluation of acute heart failure.
Omland T. Omland T. Crit Care Med. 2008 Jan;36(1 Suppl):S17-27. doi: 10.1097/01.CCM.0000296266.74913.85. Crit Care Med. 2008. PMID: 18158473 Review.
BACKGROUND: Circulating concentrations of B-type natriuretic peptide (BNP) and the aminoterminal fragment (NT-proBNP) of its prohormone (proBNP) are increased in congestive heart failure in proportion to the severity of symptoms, the degree of l …
BACKGROUND: Circulating concentrations of B-type natriuretic peptide (BNP) and the aminoterminal fragment (NT-proBNP
[Brain natriuretic peptide: physiological, biological and clinical aspects].
Cauliez B, Berthe MC, Lavoinne A. Cauliez B, et al. Ann Biol Clin (Paris). 2005 Jan-Feb;63(1):15-25. Ann Biol Clin (Paris). 2005. PMID: 15689309 Free article. Review. French.
The BNP and NT-proBNP concentrations are measured using automated rapid immunoassay techniques. ...These peptides are prognostic markers both in heart failure and in acute coronary syndromes. In renal insufficiency, the interpretation of the increase i …
The BNP and NT-proBNP concentrations are measured using automated rapid immunoassay techniques. ...These peptides are p …
[Natriuretic peptides--new diagnostic markers in heart disease].
Angermann CE, Ertl G. Angermann CE, et al. Herz. 2004 Sep;29(6):609-17. doi: 10.1007/s00059-004-2619-8. Herz. 2004. PMID: 15912436 Review. German.
In patients with heart failure, increased wall stretch due to volume and pressure overload leads to an increase in circulating natriuretic peptides (ANP and BNP and their N-terminal fragments NT-proANP and NT-proBNP). ...Thus, increased p …
In patients with heart failure, increased wall stretch due to volume and pressure overload leads to an increase in circulat
Circulating B-type natriuretic peptides in patients with acute coronary syndromes. Pathophysiological, prognostical and therapeutical considerations.
Jarai R, Wojta J, Huber K. Jarai R, et al. Thromb Haemost. 2005 Nov;94(5):926-32. doi: 10.1160/TH05-06-0395. Thromb Haemost. 2005. PMID: 16363232 Review.
The underlying mechanisms of BNP/Nt-proBNP elevations in patients with ACS are still not known at present. ...The remarkably high short- and long-term mortality rate associated with increases of BNP/Nt-proBNP elevations clearly show the need of …
The underlying mechanisms of BNP/Nt-proBNP elevations in patients with ACS are still not known at present. ...The remarkably h …