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2015 2
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Page 1
Galectin-3 Is Associated with Cardiac Fibrosis and an Increased Risk of Sudden Death.
Sherpa MD, Sonkawade SD, Jonnala V, Pokharel S, Khazaeli M, Yatsynovich Y, Kalot MA, Weil BR, Canty JM Jr, Sharma UC. Sherpa MD, et al. Cells. 2023 Apr 23;12(9):1218. doi: 10.3390/cells12091218. Cells. 2023. PMID: 37174619 Free PMC article. Review.
BACKGROUND: Myocardial fibrosis is a common postmortem finding among individuals with Sudden Cardiac Death (SCD). Numerous in vivo and in vitro studies have shown that increased galectin-3 (gal3) expression into the myocardium is associated with higher incide …
BACKGROUND: Myocardial fibrosis is a common postmortem finding among individuals with Sudden Cardiac Death (SCD). Numerous in vivo and in vi …
Biomarkers of disease activity in dermatomyositis.
Lu X, Peng Q, Wang G. Lu X, et al. Curr Opin Rheumatol. 2022 Nov 1;34(6):289-294. doi: 10.1097/BOR.0000000000000905. Epub 2022 Aug 30. Curr Opin Rheumatol. 2022. PMID: 36082751 Review.
PURPOSE OF REVIEW: This review provides updates regarding biomarker studies that address key clinical unmet needs, which relate to the evaluation of the disease activity in patients with dermatomyositis. RECENT FINDINGS: Increasing evidence supports that the serum level …
PURPOSE OF REVIEW: This review provides updates regarding biomarker studies that address key clinical unmet needs, which relate to the evalu …
beta-Adrenoceptor activation affects galectin-3 as a biomarker and therapeutic target in heart disease.
Du XJ, Zhao WB, Nguyen MN, Lu Q, Kiriazis H. Du XJ, et al. Br J Pharmacol. 2019 Jul;176(14):2449-2464. doi: 10.1111/bph.14620. Epub 2019 Apr 7. Br J Pharmacol. 2019. PMID: 30756388 Free PMC article. Review.
However, our knowledge is poor on the mechanism(s) that determine the blood level or regulate cardiac expression of Gal-3. Recent studies have demonstrated that enhanced beta-adrenoceptor activity is a determinant of both circulating concentration and cardiac …
However, our knowledge is poor on the mechanism(s) that determine the blood level or regulate cardiac expression of Gal-3. Rec …
Galectin-3 and post-myocardial infarction cardiac remodeling.
Meijers WC, van der Velde AR, Pascual-Figal DA, de Boer RA. Meijers WC, et al. Eur J Pharmacol. 2015 Sep 15;763(Pt A):115-21. doi: 10.1016/j.ejphar.2015.06.025. Epub 2015 Jun 19. Eur J Pharmacol. 2015. PMID: 26101067 Review.
In clinical studies, circulating galectin-3 levels have been shown to identify patients at risk for new-onset heart failure and atrial fibrillation. Circulating galectin-3 levels also predict progressive left ventricular dil …
In clinical studies, circulating galectin-3 levels have been shown to identify patients at risk for new-onset he …
Galectin-3 is Associated with Heart Failure Incidence: A Meta-Analysis.
Baccouche BM, Mahmoud MA, Nief C, Patel K, Natterson-Horowitz B. Baccouche BM, et al. Curr Cardiol Rev. 2023;19(3):e171122211004. doi: 10.2174/1573403X19666221117122012. Curr Cardiol Rev. 2023. PMID: 36397629 Free PMC article. Review.
This paper aimed to qualitatively and quantitatively evaluate the evidence associating levels of galectin-3 with the risk of incident HF. METHODS: A review of PUBMED-indexed peer-reviewed literature was performed. ...CONCLUSION: There is a significant positiv …
This paper aimed to qualitatively and quantitatively evaluate the evidence associating levels of galectin-3 with the ri …
Circulating Galectin-3 levels in women with polycystic ovary syndrome: A meta-analysis.
Bahreiny SS, Bastani MN, Aghaei M, Dabbagh MR, Mahdizade AH. Bahreiny SS, et al. Taiwan J Obstet Gynecol. 2024 Jan;63(1):37-45. doi: 10.1016/j.tjog.2023.10.003. Taiwan J Obstet Gynecol. 2024. PMID: 38216266 Free article. Review.
Pooled standardized mean difference (SMD) and 95 % confidence interval [CI] were used to evaluate the association between Galectin-3 levels and PCOS. The results indicated a significant association between PCOS and galectin-3 levels (SMD …
Pooled standardized mean difference (SMD) and 95 % confidence interval [CI] were used to evaluate the association between Galectin- …
Galectins as potential pharmacological targets in renal injuries of diverse etiology.
Gu M, Mei X, Zhao Y. Gu M, et al. Eur J Pharmacol. 2020 Aug 15;881:173213. doi: 10.1016/j.ejphar.2020.173213. Epub 2020 May 22. Eur J Pharmacol. 2020. PMID: 32450176 Review.
There is an increase in galectin-3 in the circulation as well as on the kidneys in chronic kidney disease patients. ...The preclinical studies also correlate the increase in galectin-3 levels with renal dysfunction. Accordin …
There is an increase in galectin-3 in the circulation as well as on the kidneys in chronic kidney disease patien …
The search for efficient diagnostic and prognostic biomarkers of heart failure.
Emdin M, Mirizzi G, Pastormerlo LE, Poletti R, Giannelli E, Prontera C, Passino C, Vergaro G. Emdin M, et al. Future Cardiol. 2016 May;12(3):327-37. doi: 10.2217/fca.16.1. Epub 2016 Apr 19. Future Cardiol. 2016. PMID: 27092725 Review.
Several biomarkers have been tested for screening, diagnosis and prognosis purposes, as well as to guide treatment in heart failure, but only the assay of circulating B-type natriuretic peptides has widely recognized applications for clinical decision-making. Natriuretic p …
Several biomarkers have been tested for screening, diagnosis and prognosis purposes, as well as to guide treatment in heart failure, but onl …
ST2 in stable and unstable ischemic heart diseases.
Richards AM, Di Somma S, Mueller T. Richards AM, et al. Am J Cardiol. 2015 Apr 2;115(7 Suppl):48B-58B. doi: 10.1016/j.amjcard.2015.01.041. Epub 2015 Jan 23. Am J Cardiol. 2015. PMID: 25678392 Review.
Circulating suppression of tumorigenicity 2 (ST2) predicts cardiovascular outcomes and mortality in ischemic heart disease (IHD). ...Although of little diagnostic utility in IHD, ST2 does offer prognostic information. In ST elevation myocardial infarction, ST2 levels …
Circulating suppression of tumorigenicity 2 (ST2) predicts cardiovascular outcomes and mortality in ischemic heart disease (IHD). ... …