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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1969 1
1974 1
1978 1
1983 1
1985 1
1988 3
1990 1
1991 4
1992 6
1993 6
1994 8
1995 7
1996 3
1997 3
1998 4
1999 6
2000 6
2001 7
2002 14
2003 10
2004 34
2005 27
2006 35
2007 30
2008 32
2009 19
2010 27
2011 43
2012 43
2013 75
2014 88
2015 92
2016 79
2017 87
2018 73
2019 96
2020 84
2021 99
2022 90
2023 102
2024 20

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1,191 results

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Page 1
Role of cytokines in intervertebral disc degeneration: pain and disc content.
Risbud MV, Shapiro IM. Risbud MV, et al. Nat Rev Rheumatol. 2014 Jan;10(1):44-56. doi: 10.1038/nrrheum.2013.160. Epub 2013 Oct 29. Nat Rev Rheumatol. 2014. PMID: 24166242 Free PMC article. Review.
Degeneration of the intervertebral discs (IVDs) is a major contributor to back, neck and radicular pain. ...The resulting imbalance in catabolic and anabolic responses leads to the degeneration of IVD tissues, as well as disc herniation and radicular p
Degeneration of the intervertebral discs (IVDs) is a major contributor to back, neck and radicular pain. ...The resulting imba
Macrophages and Intervertebral Disc Degeneration.
Koroth J, Buko EO, Abbott R, Johnson CP, Ogle BM, Stone LS, Ellingson AM, Bradley EW. Koroth J, et al. Int J Mol Sci. 2023 Jan 10;24(2):1367. doi: 10.3390/ijms24021367. Int J Mol Sci. 2023. PMID: 36674887 Free PMC article. Review.
With little inherent regenerative capacity, degeneration of the intervertebral disc results in intervertebral disc disease, which contributes to low back pain and significant disability in many individuals. ...Moreover, studies show elevated mac …
With little inherent regenerative capacity, degeneration of the intervertebral disc results in intervertebral
Intervertebral Disc Diseases PART 2: A Review of the Current Diagnostic and Treatment Strategies for Intervertebral Disc Disease.
Wu PH, Kim HS, Jang IT. Wu PH, et al. Int J Mol Sci. 2020 Mar 20;21(6):2135. doi: 10.3390/ijms21062135. Int J Mol Sci. 2020. PMID: 32244936 Free PMC article. Review.
With an aging population, there is a proportional increase in the prevalence of intervertebral disc diseases. Intervertebral disc diseases are the leading cause of lower back pain and disability. With a high prevalence of asymptomatic intervertebral
With an aging population, there is a proportional increase in the prevalence of intervertebral disc diseases. Intervertebra
MicroRNAs in Intervertebral Disc Degeneration, Apoptosis, Inflammation, and Mechanobiology.
Cazzanelli P, Wuertz-Kozak K. Cazzanelli P, et al. Int J Mol Sci. 2020 May 20;21(10):3601. doi: 10.3390/ijms21103601. Int J Mol Sci. 2020. PMID: 32443722 Free PMC article. Review.
Intervertebral disc (IVD) degeneration is a multifactorial pathological process associated with low back pain, the leading cause of years lived in disability worldwide. ...The impact of nonphysiological mechanical stresses on IVD degeneration and infla
Intervertebral disc (IVD) degeneration is a multifactorial pathological process associated with low back pain, the lead
Mesenchymal Stem Cell-Derived Exosomes and Intervertebral Disc Regeneration: Review.
Bhujel B, Shin HE, Choi DJ, Han I. Bhujel B, et al. Int J Mol Sci. 2022 Jun 30;23(13):7306. doi: 10.3390/ijms23137306. Int J Mol Sci. 2022. PMID: 35806304 Free PMC article. Review.
Intervertebral disc degeneration (IVDD) is a common cause of lower back pain (LBP), which burdens individuals and society as a whole. IVDD occurs as a result of aging, mechanical trauma, lifestyle factors, and certain genetic abnormalities, leads to loss of n
Intervertebral disc degeneration (IVDD) is a common cause of lower back pain (LBP), which burdens individuals and socie
Mechanics and biology in intervertebral disc degeneration: a vicious circle.
Vergroesen PP, Kingma I, Emanuel KS, Hoogendoorn RJ, Welting TJ, van Royen BJ, van Dieën JH, Smit TH. Vergroesen PP, et al. Osteoarthritis Cartilage. 2015 Jul;23(7):1057-70. doi: 10.1016/j.joca.2015.03.028. Epub 2015 Mar 27. Osteoarthritis Cartilage. 2015. PMID: 25827971 Free article. Review.
Intervertebral disc degeneration is a major cause of low back pain. Despite its long history and large socio-economical impact in western societies, the initiation and progress of disc degeneration is not well understood and a generic disease mo
Intervertebral disc degeneration is a major cause of low back pain. Despite its long history and large socio-economical
Stem Cells and Exosomes: New Therapies for Intervertebral Disc Degeneration.
Krut Z, Pelled G, Gazit D, Gazit Z. Krut Z, et al. Cells. 2021 Aug 29;10(9):2241. doi: 10.3390/cells10092241. Cells. 2021. PMID: 34571890 Free PMC article. Review.
Intervertebral disc degeneration (IVDD) occurs as a result of an imbalance of the anabolic and catabolic processes in the intervertebral disc, leading to an alteration in the composition of the extracellular matrix (ECM), loss of nucleus pulposu
Intervertebral disc degeneration (IVDD) occurs as a result of an imbalance of the anabolic and catabolic processes in t
MRI Findings of Disc Degeneration are More Prevalent in Adults with Low Back Pain than in Asymptomatic Controls: A Systematic Review and Meta-Analysis.
Brinjikji W, Diehn FE, Jarvik JG, Carr CM, Kallmes DF, Murad MH, Luetmer PH. Brinjikji W, et al. AJNR Am J Neuroradiol. 2015 Dec;36(12):2394-9. doi: 10.3174/ajnr.A4498. Epub 2015 Sep 10. AJNR Am J Neuroradiol. 2015. PMID: 26359154 Free PMC article. Review.
Two reviewers evaluated each article for the following outcomes: disc bulge, disc degeneration, disc extrusion, disc protrusion, annular fissures, Modic 1 changes, any Modic changes, central canal stenosis, spondylolisthesis, and spondylolysis. …
Two reviewers evaluated each article for the following outcomes: disc bulge, disc degeneration, disc extrusion, …
The role of IL-1beta and TNF-alpha in intervertebral disc degeneration.
Wang Y, Che M, Xin J, Zheng Z, Li J, Zhang S. Wang Y, et al. Biomed Pharmacother. 2020 Nov;131:110660. doi: 10.1016/j.biopha.2020.110660. Epub 2020 Aug 24. Biomed Pharmacother. 2020. PMID: 32853910 Free article. Review.
Low back pain (LBP), a prevalent and costly disease around the world, is predominantly caused by intervertebral disc (IVD) degeneration (IDD). LBP also presents a substantial burden to public health and the economy. ...Because IL-1beta and TNF-alpha inhibitio …
Low back pain (LBP), a prevalent and costly disease around the world, is predominantly caused by intervertebral disc (IVD) …
A new immunometabolic perspective of intervertebral disc degeneration.
Francisco V, Pino J, González-Gay MÁ, Lago F, Karppinen J, Tervonen O, Mobasheri A, Gualillo O. Francisco V, et al. Nat Rev Rheumatol. 2022 Jan;18(1):47-60. doi: 10.1038/s41584-021-00713-z. Epub 2021 Nov 29. Nat Rev Rheumatol. 2022. PMID: 34845360 Review.
Intervertebral disc (IVD) degeneration is a common finding on spine imaging that increases in prevalence with age. IVD degeneration is a frequent cause of low back pain, which is a leading cause of disability. ...
Intervertebral disc (IVD) degeneration is a common finding on spine imaging that increases in prevalence with age. IVD
1,191 results