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1988
2025

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1988 1
1990 3
1992 3
1993 2
1994 2
1995 1
1997 1
1999 2
2000 1
2001 6
2002 3
2003 3
2004 2
2006 4
2007 1
2008 3
2010 3
2011 2
2012 1
2013 2
2014 6
2015 3
2016 5
2017 6
2018 1
2019 4
2020 4
2021 3
2022 4
2023 3
2024 3
2025 0

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80 results

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Page 1
Ferroptosis in Parkinson's disease: Molecular mechanisms and therapeutic potential.
Ding XS, Gao L, Han Z, Eleuteri S, Shi W, Shen Y, Song ZY, Su M, Yang Q, Qu Y, Simon DK, Wang XL, Wang B. Ding XS, et al. Ageing Res Rev. 2023 Nov;91:102077. doi: 10.1016/j.arr.2023.102077. Epub 2023 Sep 24. Ageing Res Rev. 2023. PMID: 37742785 Review.
Parkinson's Disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra (SN), leading to motor and non-motor symptoms. While the exact mechanisms remain complex and multifaceted, several molecular pathways have been implicat …
Parkinson's Disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra (SN), leadin …
The role of zinc, copper, manganese and iron in neurodegenerative diseases.
Mezzaroba L, Alfieri DF, Colado Simão AN, Vissoci Reiche EM. Mezzaroba L, et al. Neurotoxicology. 2019 Sep;74:230-241. doi: 10.1016/j.neuro.2019.07.007. Epub 2019 Aug 1. Neurotoxicology. 2019. PMID: 31377220 Review.
The aim of this study was to review the effects of the essential metals zinc (Zn), copper (Cu), manganese (Mn) and iron (Fe) on the central nervous system (CNS), as well as the mechanisms involved in their neurotoxicity. ...High levels of Cu, Mn and Fe participate in the f …
The aim of this study was to review the effects of the essential metals zinc (Zn), copper (Cu), manganese (Mn) and iron (Fe) on the c …
A brief history of brain iron accumulation in Parkinson disease and related disorders.
Foley PB, Hare DJ, Double KL. Foley PB, et al. J Neural Transm (Vienna). 2022 Jun;129(5-6):505-520. doi: 10.1007/s00702-022-02505-5. Epub 2022 May 9. J Neural Transm (Vienna). 2022. PMID: 35534717 Free PMC article. Review.
Iron has a long and storied history in Parkinson disease and related disorders. This essential micronutrient is critical for normal brain function, but abnormal brain iron accumulation has been associated with extrapyramidal disease for a century. Precisely w
Iron has a long and storied history in Parkinson disease and related disorders. This essential micronutrient is critical for normal b
Neuromelanin in parkinsonian disorders: an update.
Martin-Bastida A, Pietracupa S, Piccini P. Martin-Bastida A, et al. Int J Neurosci. 2017 Dec;127(12):1116-1123. doi: 10.1080/00207454.2017.1325883. Epub 2017 May 11. Int J Neurosci. 2017. PMID: 28460588 Review.
Neuromelanin (NM) is a dark pigment that accumulates linearly with aging in substantia nigra (SN) and locus coeruleus (LC). The dual protective and toxic role of NM has been hypothesized according to its intraneuronal or extraneuronal deposition. ...The param …
Neuromelanin (NM) is a dark pigment that accumulates linearly with aging in substantia nigra (SN) and locus coeruleus ( …
Mitochondrial iron dyshomeostasis and its potential as a therapeutic target for Parkinson's disease.
Xiao Z, Wang X, Pan X, Xie J, Xu H. Xiao Z, et al. Exp Neurol. 2024 Feb;372:114614. doi: 10.1016/j.expneurol.2023.114614. Epub 2023 Nov 23. Exp Neurol. 2024. PMID: 38007207 Review.
Abnormal iron accumulation has been implicated in the etiology of Parkinson's disease (PD). Understanding how iron damages dopaminergic neurons in the substantia nigra (SN) of PD is particularly important for developing targeted neurotherapeutic …
Abnormal iron accumulation has been implicated in the etiology of Parkinson's disease (PD). Understanding how iron dama …
The neurotoxicity of iron, copper and manganese in Parkinson's and Wilson's diseases.
Dusek P, Roos PM, Litwin T, Schneider SA, Flaten TP, Aaseth J. Dusek P, et al. J Trace Elem Med Biol. 2015;31:193-203. doi: 10.1016/j.jtemb.2014.05.007. Epub 2014 Jun 2. J Trace Elem Med Biol. 2015. PMID: 24954801 Review.
In Parkinson's disease local dysregulation of iron metabolism in the substantia nigra (SN) seems to be related to neurodegeneration with an increase in SN iron concentration, accompanied by decreased SN Cu and ceruloplasmin concentrations and increased …
In Parkinson's disease local dysregulation of iron metabolism in the substantia nigra (SN) seems to be related to neuro …
Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease.
Zucca FA, Segura-Aguilar J, Ferrari E, Muñoz P, Paris I, Sulzer D, Sarna T, Casella L, Zecca L. Zucca FA, et al. Prog Neurobiol. 2017 Aug;155:96-119. doi: 10.1016/j.pneurobio.2015.09.012. Epub 2015 Oct 9. Prog Neurobiol. 2017. PMID: 26455458 Free PMC article. Review.
There are several interrelated mechanisms involving iron, dopamine, and neuromelanin in neurons. Neuromelanin accumulates during aging and is the catecholamine-derived pigment of the dopamine neurons of the substantia nigra and norepinephrine neurons o …
There are several interrelated mechanisms involving iron, dopamine, and neuromelanin in neurons. Neuromelanin accumulates duri …
Neurodegeneration with Brain Iron Accumulation.
Schneider SA. Schneider SA. Curr Neurol Neurosci Rep. 2016 Jan;16(1):9. doi: 10.1007/s11910-015-0608-3. Curr Neurol Neurosci Rep. 2016. PMID: 26739693 Review.
Syndromes with neurodegeneration with brain iron accumulation (NBIA) are a group of neurodegenerative disorders characterized by abnormalities in brain iron metabolism with excess iron accumulation in the globus pallidus and to a lesser degree i …
Syndromes with neurodegeneration with brain iron accumulation (NBIA) are a group of neurodegenerative disorders characterized …
Brain Iron Metabolism Dysfunction in Parkinson's Disease.
Jiang H, Wang J, Rogers J, Xie J. Jiang H, et al. Mol Neurobiol. 2017 May;54(4):3078-3101. doi: 10.1007/s12035-016-9879-1. Epub 2016 Apr 2. Mol Neurobiol. 2017. PMID: 27039308 Review.
Understanding how iron accumulates in the substantia nigra (SN) and why it specifically targets dopaminergic (DAergic) neurons is particularly warranted for PD, as this knowledge may provide new therapeutic avenues for a more targeted neurotherapeutic …
Understanding how iron accumulates in the substantia nigra (SN) and why it specifically targets dopaminergic (DA …
Iron and dopamine: a toxic couple.
Hare DJ, Double KL. Hare DJ, et al. Brain. 2016 Apr;139(Pt 4):1026-35. doi: 10.1093/brain/aww022. Brain. 2016. PMID: 26962053 Review.
Iron accumulation is a cardinal feature of degenerating regions in the Parkinson's disease brain. As a potent pro-oxidant, redox-active iron may be a key player in upstream mechanisms that precipitate cell death in this disorder. ...
Iron accumulation is a cardinal feature of degenerating regions in the Parkinson's disease brain. As a potent pro-oxidant, red
80 results