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hERG quality control and the long QT syndrome.
Foo B, Williamson B, Young JC, Lukacs G, Shrier A. Foo B, et al. J Physiol. 2016 May 1;594(9):2469-81. doi: 10.1113/JP270531. Epub 2016 Feb 9. J Physiol. 2016. PMID: 26718903 Free PMC article. Review.
A Practical Approach to Avoiding Cardiovascular Adverse Effects of Psychoactive Medications.
Brouillette J, Nattel S. Brouillette J, et al. Can J Cardiol. 2017 Dec;33(12):1577-1586. doi: 10.1016/j.cjca.2017.09.001. Epub 2017 Sep 11. Can J Cardiol. 2017. PMID: 29173600 Review.
We consider adverse reactions in terms of: (1) arrhythmias (particularly acquired long QT syndrome); (2) blood pressure; (3) ventricular function; (4) effect on risk factors; (5) teratogenicity; and (6) drug interactions. ...
We consider adverse reactions in terms of: (1) arrhythmias (particularly acquired long QT syndrome); (2) blood p …
Defective protein trafficking in hERG-associated hereditary long QT syndrome (LQT2): molecular mechanisms and restoration of intracellular protein processing.
Thomas D, Kiehn J, Katus HA, Karle CA. Thomas D, et al. Cardiovasc Res. 2003 Nov 1;60(2):235-41. doi: 10.1016/j.cardiores.2003.08.002. Cardiovasc Res. 2003. PMID: 14613852 Review.
Mutations in the human-ether-a-go-go-related gene (hERG), encoding the protein underlying the repolarizing cardiac I(Kr) potassium current, cause chromosome 7-linked long QT syndrome 2. Loss of function of mutant hERG channels may be caused by several …
Mutations in the human-ether-a-go-go-related gene (hERG), encoding the protein underlying the repolarizing cardiac I(Kr) potassium current, …