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Page 1
Ion channels, long QT syndrome and arrhythmogenesis in ageing.
Jeevaratnam K, Chadda KR, Salvage SC, Valli H, Ahmad S, Grace AA, Huang CL. Jeevaratnam K, et al. Clin Exp Pharmacol Physiol. 2017 Dec;44 Suppl 1(Suppl Suppl 1):38-45. doi: 10.1111/1440-1681.12721. Epub 2017 Sep 20. Clin Exp Pharmacol Physiol. 2017. PMID: 28024120 Free PMC article. Review.
Late sodium current associated cardiac electrophysiological and mechanical dysfunction.
Yu S, Li G, Huang CL, Lei M, Wu L. Yu S, et al. Pflugers Arch. 2018 Mar;470(3):461-469. doi: 10.1007/s00424-017-2079-7. Epub 2017 Nov 10. Pflugers Arch. 2018. PMID: 29127493 Review.
The endogenous I(NaL) is relatively small in normal hearts but exerts functionally significant effects on cardiomyocyte repolarization with potentially pro-arrhythmic effects in hearts with reduced repolarization reserve. Enhanced I(Na,L) occurs in long QT syndro
The endogenous I(NaL) is relatively small in normal hearts but exerts functionally significant effects on cardiomyocyte repolarization with …
Cardiac late Na⁺ current: proarrhythmic effects, roles in long QT syndromes, and pathological relationship to CaMKII and oxidative stress.
Belardinelli L, Giles WR, Rajamani S, Karagueuzian HS, Shryock JC. Belardinelli L, et al. Heart Rhythm. 2015 Feb;12(2):440-8. doi: 10.1016/j.hrthm.2014.11.009. Epub 2014 Nov 11. Heart Rhythm. 2015. PMID: 25460862 Review.
An increase in I(Na-L) reduces repolarization reserve in atrial and ventricular myocytes and prolongs the action potential duration and the QT interval. An enhanced I(Na-L) is a cause of long QT syndrome 3. I(Na-L) may be a cause of afterdepolarization …
An increase in I(Na-L) reduces repolarization reserve in atrial and ventricular myocytes and prolongs the action potential duration and the …
Diagnosis and treatment of arrhythmias.
Perry JC, Garson A Jr. Perry JC, et al. Adv Pediatr. 1989;36:177-99. Adv Pediatr. 1989. PMID: 2675568 Review.
Do not (1) use digoxin chronically in overt WPW syndrome, (2) miss the diagnosis of long QT syndrome, (3) diagnose "SVT with aberration"--rule out VT first, (4) use sinus-suppressant drugs in patients with sick sinus syndrome without an implanted pacem …
Do not (1) use digoxin chronically in overt WPW syndrome, (2) miss the diagnosis of long QT syndrome, (3) diagno …
Protein-protein interactions involving voltage-gated sodium channels: Post-translational regulation, intracellular trafficking and functional expression.
Shao D, Okuse K, Djamgoz MB. Shao D, et al. Int J Biochem Cell Biol. 2009 Jul;41(7):1471-81. doi: 10.1016/j.biocel.2009.01.016. Epub 2009 Feb 2. Int J Biochem Cell Biol. 2009. PMID: 19401147 Review.
VGSC abnormalities are associated with various diseases including epilepsy, long-QT syndrome 3, Brugada syndrome, sudden infant death syndrome and, more recently, various human cancers. ...
VGSC abnormalities are associated with various diseases including epilepsy, long-QT syndrome 3, Brugada syndrome …