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Page 1
Genetics of migraine: where are we now?
Grangeon L, Lange KS, Waliszewska-Prosół M, Onan D, Marschollek K, Wiels W, Mikulenka P, Farham F, Gollion C, Ducros A; European Headache Federation School of Advanced Studies (EHF-SAS). Grangeon L, et al. J Headache Pain. 2023 Feb 20;24(1):12. doi: 10.1186/s10194-023-01547-8. J Headache Pain. 2023. PMID: 36800925 Free PMC article. Review.
In monogenic migraines, including familial hemiplegic migraine and migraine with aura associated with hereditary small-vessel disorders, the identified genes code for proteins expressed in neurons, glial cells, or vessels, all of which increase suscept …
In monogenic migraines, including familial hemiplegic migraine and migraine with aura associated with hereditary …
SCN1A-related phenotypes: Epilepsy and beyond.
Scheffer IE, Nabbout R. Scheffer IE, et al. Epilepsia. 2019 Dec;60 Suppl 3:S17-S24. doi: 10.1111/epi.16386. Epilepsia. 2019. PMID: 31904117 Review.
Although seizures are the most commonly reported symptom in DS, many additional issues critically affect patients' cognitive and behavioral functioning. Hemiplegic migraine (HM) is a rare form of migraine with aura, characterized by the emergence of hemipares …
Although seizures are the most commonly reported symptom in DS, many additional issues critically affect patients' cognitive and behavioral …
Familial hemiplegic migraine.
Villar-Martinez MD, Moreno-Ajona D, Goadsby PJ. Villar-Martinez MD, et al. Handb Clin Neurol. 2024;203:135-144. doi: 10.1016/B978-0-323-90820-7.00007-0. Handb Clin Neurol. 2024. PMID: 39174245 Review.
Hemiplegic migraine consists of attacks of migraine with aura that includes reversible motor weakness. ...The most described subtypes of familial hemiplegic migraine include FHM1, FHM2, and FHM3. These have been demonstrated to have a mut
Hemiplegic migraine consists of attacks of migraine with aura that includes reversible motor weakness. ...The most desc
Migraine - a borderland disease to epilepsy: near it but not of it.
Paungarttner J, Quartana M, Patti L, Sklenárová B, Farham F, Jiménez IH, Soylu MG, Vlad IM, Tasdelen S, Mateu T, Marsico O, Reina F, Tischler V, Lampl C; European Headache Federation School of Advanced Studies (EHF – SAS). Paungarttner J, et al. J Headache Pain. 2024 Jan 26;25(1):11. doi: 10.1186/s10194-024-01719-0. J Headache Pain. 2024. PMID: 38273253 Free PMC article. Review.
There are several shared pathophysiological mechanisms, like CSD, the likely underlying cause of migraine aura, or neurotransmitters, mainly Glutamate and GABA, which represent important roles in triggering migraine attacks and seizures. The genetic interrelations b …
There are several shared pathophysiological mechanisms, like CSD, the likely underlying cause of migraine aura, or neurotransmitters, …
Familial hemiplegic migraine.
Pietrobon D. Pietrobon D. Neurotherapeutics. 2007 Apr;4(2):274-84. doi: 10.1016/j.nurt.2007.01.008. Neurotherapeutics. 2007. PMID: 17395138 Free article. Review.
Familial hemiplegic migraine (FHM) is a rare and genetically heterogeneous autosomal dominant subtype of migraine with aura. ...This review discusses the functional studies of two FHM1 knockin mice and of several FHM mutants in heterologous expression
Familial hemiplegic migraine (FHM) is a rare and genetically heterogeneous autosomal dominant subtype of migraine
CaV2.1 channelopathies.
Pietrobon D. Pietrobon D. Pflugers Arch. 2010 Jul;460(2):375-93. doi: 10.1007/s00424-010-0802-8. Epub 2010 Mar 4. Pflugers Arch. 2010. PMID: 20204399 Review.
Mutations in the CACNA1A gene that encodes the pore-forming alpha1 subunit of human voltage-gated CaV2.1 (P/Q-type) Ca2+ channels cause several autosomal-dominant neurologic disorders, including familial hemiplegic migraine type 1 (FHM1), episod …
Mutations in the CACNA1A gene that encodes the pore-forming alpha1 subunit of human voltage-gated CaV2.1 (P/Q-type) Ca2+ channels cau …
Migraine: Calcium Channels and Glia.
Kowalska M, Prendecki M, Piekut T, Kozubski W, Dorszewska J. Kowalska M, et al. Int J Mol Sci. 2021 Mar 7;22(5):2688. doi: 10.3390/ijms22052688. Int J Mol Sci. 2021. PMID: 33799975 Free PMC article. Review.
Migraine is a common neurological disease that affects about 11% of the adult population. ...The mechanism of CSD, stemming in part from aberrant interactions between neurons and glia have been studied in models of familial hemiplegic migraine (FHM), a
Migraine is a common neurological disease that affects about 11% of the adult population. ...The mechanism of CSD, stemming in part f
CaV2.1 voltage activated calcium channels and synaptic transmission in familial hemiplegic migraine pathogenesis.
Uchitel OD, Inchauspe CG, Urbano FJ, Di Guilmi MN. Uchitel OD, et al. J Physiol Paris. 2012 Jan;106(1-2):12-22. doi: 10.1016/j.jphysparis.2011.10.004. Epub 2011 Nov 2. J Physiol Paris. 2012. PMID: 22074995 Review.
In this review we focus on the role of mutated CaV2.1 (i.e., P/Q-type) voltage-activated Ca2+ channels, and on the ultimate consequences that mutations causing familial hemiplegic migraine type-1 (FHM1) have in neurotransmitter release. ...FHM1 …
In this review we focus on the role of mutated CaV2.1 (i.e., P/Q-type) voltage-activated Ca2+ channels, and on the ultimate consequen …
Genetic effects of ATP1A2 in familial hemiplegic migraine type II and animal models.
Gritz SM, Radcliffe RA. Gritz SM, et al. Hum Genomics. 2013 Apr 5;7(1):8. doi: 10.1186/1479-7364-7-8. Hum Genomics. 2013. PMID: 23561701 Free PMC article. Review.
In humans, mutations in ATP1A2 are associated with a rare form of hereditary migraines with aura known as familial hemiplegic migraine type II. Genetic studies in mice have revealed other neurological effects of Atp1a2 in mice including anxiety, fear, and lea …
In humans, mutations in ATP1A2 are associated with a rare form of hereditary migraines with aura known as familial hemiplegic
Molecular factors in migraine.
Kowalska M, Prendecki M, Kozubski W, Lianeri M, Dorszewska J. Kowalska M, et al. Oncotarget. 2016 Aug 2;7(31):50708-50718. doi: 10.18632/oncotarget.9367. Oncotarget. 2016. PMID: 27191890 Free PMC article. Review.
Migraine with aura (MA) and more common form - migraine without aura (MO) - are the two main clinical subtypes of disease. ...The first genetic studies of migraine were focused on the rare subtype of MA: familial hemiplegic migraine (FHM)
Migraine with aura (MA) and more common form - migraine without aura (MO) - are the two main clinical subtypes of disease. ...
79 results