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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1989 2
1995 1
1998 1
1999 1
2000 1
2003 1
2004 2
2005 1
2007 1
2008 2
2010 2
2011 2
2012 2
2013 5
2014 4
2015 1
2016 1
2017 1
2019 2
2020 4
2021 4
2022 2
2023 1
2024 0

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37 results

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Page 1
Ndufs4 knockout mouse models of Leigh syndrome: pathophysiology and intervention.
van de Wal MAE, Adjobo-Hermans MJW, Keijer J, Schirris TJJ, Homberg JR, Wieckowski MR, Grefte S, van Schothorst EM, van Karnebeek C, Quintana A, Koopman WJH. van de Wal MAE, et al. Brain. 2022 Mar 29;145(1):45-63. doi: 10.1093/brain/awab426. Brain. 2022. PMID: 34849584 Free PMC article. Review.
Dysfunction of these organelles is linked to a heterogeneous group of multisystemic disorders, including diabetes, cancer, ageing-related pathologies and rare mitochondrial diseases. With respect to the latter, mutations in subunit-encoding genes and assembly factors of th …
Dysfunction of these organelles is linked to a heterogeneous group of multisystemic disorders, including diabetes, cancer, ageing-related pa …
A guide to assessing cellular senescence in vitro and in vivo.
González-Gualda E, Baker AG, Fruk L, Muñoz-Espín D. González-Gualda E, et al. FEBS J. 2021 Jan;288(1):56-80. doi: 10.1111/febs.15570. Epub 2020 Oct 10. FEBS J. 2021. PMID: 32961620 Free article. Review.
This highly dynamic and regulated cellular state plays beneficial roles in physiology, such as during embryonic development and wound healing, but it can also result in antagonistic effects in age-related pathologies, degenerative disorders, ageing and cancer. In an effort to bet …
This highly dynamic and regulated cellular state plays beneficial roles in physiology, such as during embryonic development and wound healin …
Mechanism of action of Imeglimin: A novel therapeutic agent for type 2 diabetes.
Hallakou-Bozec S, Vial G, Kergoat M, Fouqueray P, Bolze S, Borel AL, Fontaine E, Moller DE. Hallakou-Bozec S, et al. Diabetes Obes Metab. 2021 Mar;23(3):664-673. doi: 10.1111/dom.14277. Epub 2020 Dec 29. Diabetes Obes Metab. 2021. PMID: 33269554 Free PMC article. Review.
At a cellular and molecular level, Imeglimin's underlying mechanism may involve correction of mitochondrial dysfunction, a common underlying element of T2D pathogenesis. It has been observed to rebalance respiratory chain activity (partial inhibition of Complex I an …
At a cellular and molecular level, Imeglimin's underlying mechanism may involve correction of mitochondrial dysfunction, a common und …
Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome.
Salminen A, Kaarniranta K, Kauppinen A, Ojala J, Haapasalo A, Soininen H, Hiltunen M. Salminen A, et al. Prog Neurobiol. 2013 Jul-Aug;106-107:33-54. doi: 10.1016/j.pneurobio.2013.06.002. Epub 2013 Jul 1. Prog Neurobiol. 2013. PMID: 23827971 Review.
Recent studies have indicated that the expression Beclin 1 is reduced in AD brain. Moreover, the deficiency of Beclin 1 in cultured neurons and transgenic mice provokes the deposition of amyloid-beta peptides whereas its overexpression reduces the accumulatio …
Recent studies have indicated that the expression Beclin 1 is reduced in AD brain. Moreover, the deficiency of Beclin 1
Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: implications for diagnostic and therapeutic strategies.
Chen Z, Zhong C. Chen Z, et al. Prog Neurobiol. 2013 Sep;108:21-43. doi: 10.1016/j.pneurobio.2013.06.004. Epub 2013 Jul 11. Prog Neurobiol. 2013. PMID: 23850509 Free article. Review.
We conclude that glucose metabolism abnormality plays a critical role in AD pathophysiological alterations through the induction of multiple pathogenic factors such as oxidative stress, mitochondrial dysfunction, and so forth. To clarify the causes, pathogeneses and conseq …
We conclude that glucose metabolism abnormality plays a critical role in AD pathophysiological alterations through the induction of multiple …
Is Type 2 Diabetes a Primary Mitochondrial Disorder?
Weksler-Zangen S. Weksler-Zangen S. Cells. 2022 May 12;11(10):1617. doi: 10.3390/cells11101617. Cells. 2022. PMID: 35626654 Free PMC article. Review.
The preferred treatment for diabetes in patients with mitochondrial disorders is SGLT-2i and mitochondrial GLP-1-related substances. ...However, despite the well-characterized role of mitochondria in GSIS, there is a relative lack of data in humans imp …
The preferred treatment for diabetes in patients with mitochondrial disorders is SGLT-2i and mitochondrial GLP-1-relate …
Ketogenic Diets in the Treatment of Epilepsy.
Elia M, Klepper J, Leiendecker B, Hartmann H. Elia M, et al. Curr Pharm Des. 2017;23(37):5691-5701. doi: 10.2174/1381612823666170809101517. Curr Pharm Des. 2017. PMID: 28799513 Review.
Ketogenic diet (KD), first proposed at the beginning of the last century, is complex and has anticonvulsant effects, yet not completely understood. ...RESULTS: KDs may be considered first choice treatment in some specific metabolic conditions, such as glucosetransporter …
Ketogenic diet (KD), first proposed at the beginning of the last century, is complex and has anticonvulsant effects, yet not complete …
Sphingolipids as a Culprit of Mitochondrial Dysfunction in Insulin Resistance and Type 2 Diabetes.
Roszczyc-Owsiejczuk K, Zabielski P. Roszczyc-Owsiejczuk K, et al. Front Endocrinol (Lausanne). 2021 Mar 18;12:635175. doi: 10.3389/fendo.2021.635175. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 33815291 Free PMC article. Review.
Sphingolipids, in addition to their direct impact on the insulin signaling pathway, may be responsible for other negative aspects of diabetes, namely mitochondrial dysfunction and deficiency. Mitochondrial health, which is characterized by appropriate mito
Sphingolipids, in addition to their direct impact on the insulin signaling pathway, may be responsible for other negative aspects of diabete …
The many faces of plectin and plectinopathies: pathology and mechanisms.
Winter L, Wiche G. Winter L, et al. Acta Neuropathol. 2013 Jan;125(1):77-93. doi: 10.1007/s00401-012-1026-0. Epub 2012 Aug 3. Acta Neuropathol. 2013. PMID: 22864774 Review.
EBS-MD patients and plectin-deficient mice display pathologic desmin-positive protein aggregates, degenerated myofibrils, and mitochondrial abnormalities, the hallmarks of myofibrillar myopathies. In addition to EBS-MD, plectin mutations have been shown to cause EBS …
EBS-MD patients and plectin-deficient mice display pathologic desmin-positive protein aggregates, degenerated myofibrils, and mito
The molecular basis of human complex I deficiency.
Tucker EJ, Compton AG, Calvo SE, Thorburn DR. Tucker EJ, et al. IUBMB Life. 2011 Sep;63(9):669-77. doi: 10.1002/iub.495. Epub 2011 Jul 15. IUBMB Life. 2011. PMID: 21766414 Free article. Review.
Disorders of oxidative phosphorylation (OXPHOS) have a birth prevalence of 1/5,000 and are the most common inborn errors of metabolism. The most common OXPHOS disorder is complex I deficiency. ...Molecular diagnosis of patients with complex I defici
Disorders of oxidative phosphorylation (OXPHOS) have a birth prevalence of 1/5,000 and are the most common inborn errors of metabolis …
37 results