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Year Number of Results
1989 2
1995 1
1996 1
1999 1
2000 1
2003 1
2004 1
2005 1
2006 1
2007 2
2008 1
2011 2
2012 2
2013 3
2015 1
2016 1
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2018 1
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2020 2
2024 0

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Page 1
The amyloid hypothesis of Alzheimer's disease at 25 years.
Selkoe DJ, Hardy J. Selkoe DJ, et al. EMBO Mol Med. 2016 Jun 1;8(6):595-608. doi: 10.15252/emmm.201606210. Print 2016 Jun. EMBO Mol Med. 2016. PMID: 27025652 Free PMC article. Review.
The human oligomers also induce hyperphosphorylation of tau at AD-relevant epitopes and cause neuritic dystrophy in cultured neurons. Crossing human APP with human tau transgenic mice enhances tau-positive neurotoxicity. ...
The human oligomers also induce hyperphosphorylation of tau at AD-relevant epitopes and cause neuritic dystrophy in cultured n …
Alzheimer's disease.
De-Paula VJ, Radanovic M, Diniz BS, Forlenza OV. De-Paula VJ, et al. Subcell Biochem. 2012;65:329-52. doi: 10.1007/978-94-007-5416-4_14. Subcell Biochem. 2012. PMID: 23225010 Review.
These further originate fibrillary Abeta species that accumulate into senile and neuritic plaques. These processes, along with a reduction of Abeta clearance from the brain, leads to the extracellular accumulation of Abeta, and the subsequent activation of neurotoxic casca …
These further originate fibrillary Abeta species that accumulate into senile and neuritic plaques. These processes, along with a redu …
Hereditary gelsolin amyloidosis.
Kiuru-Enari S, Haltia M. Kiuru-Enari S, et al. Handb Clin Neurol. 2013;115:659-81. doi: 10.1016/B978-0-444-52902-2.00039-4. Handb Clin Neurol. 2013. PMID: 23931809 Review.
Hereditary gelsolin amyloidosis (HGA) is an autosomally dominantly inherited form of systemic amyloidosis, characterized mainly by cranial and sensory peripheral neuropathy, corneal lattice dystrophy, and cutis laxa. HGA, originally reported from Finland and now increasing …
Hereditary gelsolin amyloidosis (HGA) is an autosomally dominantly inherited form of systemic amyloidosis, characterized mainly by cranial a …
Axonopathy in Huntington's disease.
Li JY, Conforti L. Li JY, et al. Exp Neurol. 2013 Aug;246:62-71. doi: 10.1016/j.expneurol.2012.08.010. Epub 2012 Aug 19. Exp Neurol. 2013. PMID: 22921535 Review.
Here we review the evidence of synaptic and axonal dysfunction and neurite dystrophy preceding neuronal loss in HD patients and models. ...
Here we review the evidence of synaptic and axonal dysfunction and neurite dystrophy preceding neuronal loss in HD patients an …
Implications of Insulin-Like Growth Factor-1 in Skeletal Muscle and Various Diseases.
Ahmad SS, Ahmad K, Lee EJ, Lee YH, Choi I. Ahmad SS, et al. Cells. 2020 Jul 24;9(8):1773. doi: 10.3390/cells9081773. Cells. 2020. PMID: 32722232 Free PMC article. Review.
IGF-1 is potentially useful in the management of Duchenne muscular dystrophy, muscle atrophy, and promotes neurite development. This review highlights the role of IGF-1 in skeletal muscle, its importance during myogenesis, and its involvement in different disease co …
IGF-1 is potentially useful in the management of Duchenne muscular dystrophy, muscle atrophy, and promotes neurite development …
Laminins and human disease.
McGowan KA, Marinkovich MP. McGowan KA, et al. Microsc Res Tech. 2000 Nov 1;51(3):262-79. doi: 10.1002/1097-0029(20001101)51:3<262::AID-JEMT6>3.0.CO;2-V. Microsc Res Tech. 2000. PMID: 11054876 Review.
In patients with laminin alpha 2 mutations, the bridge is disrupted and mature muscle cells apoptose. Congenital muscular dystrophy (CMD) results. The role of laminin in diseases of the nervous system is less well defined, but the extracellular protein has been shown to se …
In patients with laminin alpha 2 mutations, the bridge is disrupted and mature muscle cells apoptose. Congenital muscular dystrophy ( …
Astroglial Connexins as a Therapeutic Target for Alzheimer's Disease.
Yi C, Koulakoff A, Giaume C. Yi C, et al. Curr Pharm Des. 2017;23(33):4958-4968. doi: 10.2174/1381612823666171004151215. Curr Pharm Des. 2017. PMID: 28982320 Review.
This results in the decrease of gliotransmitter release and the alleviation of neuronal damage. This includes the reduction of oxidative stress and neuritic dystrophies in neurons that are typically associated with plaque formation in the hippocampus. ...
This results in the decrease of gliotransmitter release and the alleviation of neuronal damage. This includes the reduction of oxidative str …
Neuropathological spectrum of synucleinopathies.
Jellinger KA. Jellinger KA. Mov Disord. 2003 Sep;18 Suppl 6:S2-12. doi: 10.1002/mds.10557. Mov Disord. 2003. PMID: 14502650 Review.
Abnormal filamentous aggregates of misfolded alpha-synuclein protein are the major components of Lewy bodies, dystrophic (Lewy) neurites, and the Papp-Lantos filaments in oligodendroglia and neurons in multiple system atrophy linked to degeneration of affected brain region …
Abnormal filamentous aggregates of misfolded alpha-synuclein protein are the major components of Lewy bodies, dystrophic (Lewy) neurites …
Invited Review - Understanding cause and effect in Alzheimer's pathophysiology: Implications for clinical trials.
Boche D, Nicoll JAR. Boche D, et al. Neuropathol Appl Neurobiol. 2020 Dec;46(7):623-640. doi: 10.1111/nan.12642. Epub 2020 Jul 25. Neuropathol Appl Neurobiol. 2020. PMID: 32643143 Review.
Therefore, a sequence of (i) neocortical Abeta accumulation followed by (ii) a microglial inflammatory reaction to Abeta, causing neuritic dystrophy which promotes (iii) spread of tau from the limbic system to the neocortex with (iv) progressive tau accumulation and …
Therefore, a sequence of (i) neocortical Abeta accumulation followed by (ii) a microglial inflammatory reaction to Abeta, causing neuriti …
Dysfunction of autophagy and endosomal-lysosomal pathways: Roles in pathogenesis of Down syndrome and Alzheimer's Disease.
Colacurcio DJ, Pensalfini A, Jiang Y, Nixon RA. Colacurcio DJ, et al. Free Radic Biol Med. 2018 Jan;114:40-51. doi: 10.1016/j.freeradbiomed.2017.10.001. Epub 2017 Oct 6. Free Radic Biol Med. 2018. PMID: 28988799 Free PMC article. Review.
In DS and AD, defects in endocytosis and lysosomal function appear at the earliest stages of disease development and progress to widespread failure of intraneuronal waste clearance, neuritic dystrophy and neuronal cell death. The same genetic factors that cause or i …
In DS and AD, defects in endocytosis and lysosomal function appear at the earliest stages of disease development and progress to widespread …
25 results