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Page 1
Orotic aciduria.
[No authors listed] [No authors listed] Nutr Rev. 1969 May;27(5):142-4. doi: 10.1111/j.1753-4887.1969.tb04997.x. Nutr Rev. 1969. PMID: 4893711 Review. No abstract available.
Orotic aciduria and uridine monophosphate synthase: a reappraisal.
Bailey CJ. Bailey CJ. J Inherit Metab Dis. 2009 Dec;32 Suppl 1:S227-33. doi: 10.1007/s10545-009-1176-y. Epub 2009 Jun 27. J Inherit Metab Dis. 2009. PMID: 19562503 Review.
Three subtypes of hereditary orotic aciduria are described in the literature, all related to deficiencies in uridine monophosphate synthase, the multifunctional enzyme that contains both orotate: pyrophosphoryl transferase and orotidine monophosphate decarbox …
Three subtypes of hereditary orotic aciduria are described in the literature, all related to deficiencies in uridine monophosp …
Disorders of purines and pyrimidines.
Kelley RE, Andersson HC. Kelley RE, et al. Handb Clin Neurol. 2014;120:827-38. doi: 10.1016/B978-0-7020-4087-0.00055-3. Handb Clin Neurol. 2014. PMID: 24365355 Review.
Orotic aciduria and species specificity.
[No authors listed] [No authors listed] Nutr Rev. 1984 Aug;42(8):292-4. doi: 10.1111/j.1753-4887.1984.tb02363.x. Nutr Rev. 1984. PMID: 6384838 Review. No abstract available.
Orotic Acid, More Than Just an Intermediate of Pyrimidine de novo Synthesis.
Löffler M, Carrey EA, Zameitat E. Löffler M, et al. J Genet Genomics. 2015 May 20;42(5):207-19. doi: 10.1016/j.jgg.2015.04.001. Epub 2015 Apr 18. J Genet Genomics. 2015. PMID: 26059769 Review.
It is timely to consider the many facets of the small molecule orotic acid (OA), which is well-known as an essential intermediate of pyrimidine de novo synthesis. ...Recent genetic data link human Miller syndrome to defects in the dihydroorotate dehydrogenase (DHODH) gene, …
It is timely to consider the many facets of the small molecule orotic acid (OA), which is well-known as an essential intermediate of …
Orotic acid excretion and arginine metabolism.
Brosnan ME, Brosnan JT. Brosnan ME, et al. J Nutr. 2007 Jun;137(6 Suppl 2):1656S-1661S. doi: 10.1093/jn/137.6.1656S. J Nutr. 2007. PMID: 17513443 Free article. Review.
Carbamoyl phosphate, which accumulates within hepatic mitochondria in patients with ornithine transcarbamoylase deficiency, can diffuse to the cytosol and enter the pyrimidine pathway, resulting in greatly increased orotic acid production and excretion. This orotic …
Carbamoyl phosphate, which accumulates within hepatic mitochondria in patients with ornithine transcarbamoylase deficiency, can diffuse to t …
Orotate (orotic acid): An essential and versatile molecule.
Löffler M, Carrey EA, Zameitat E. Löffler M, et al. Nucleosides Nucleotides Nucleic Acids. 2016 Dec;35(10-12):566-577. doi: 10.1080/15257770.2016.1147580. Nucleosides Nucleotides Nucleic Acids. 2016. PMID: 27906623 Review.
Orotate (OA) is well-known as a precursor in biosynthesis of pyrimidines; in mammals it is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. ...It has recently been established that the amelio …
Orotate (OA) is well-known as a precursor in biosynthesis of pyrimidines; in mammals it is released from the mitochondrial dihydrooro …
Disorders of purine and pyrimidine metabolism.
Nyhan WL. Nyhan WL. Mol Genet Metab. 2005 Sep-Oct;86(1-2):25-33. doi: 10.1016/j.ymgme.2005.07.027. Mol Genet Metab. 2005. PMID: 16176880 Review.
Marked susceptibility to infection is also seen in disorders of pyrimidine metabolism, classically in orotic aciduria, but also in pyrimidine nucleotide depletion syndrome. Orotic aciduria is a disorder of pyrimidine nucleotide synthesis, UMP synthetas …
Marked susceptibility to infection is also seen in disorders of pyrimidine metabolism, classically in orotic aciduria, but als …
Conditional deficiencies of ornithine or arginine.
Zieve L. Zieve L. J Am Coll Nutr. 1986;5(2):167-76. doi: 10.1080/07315724.1986.10720123. J Am Coll Nutr. 1986. PMID: 3088083 Review.
In three of the inherited urea cycle disorders, ornithine insufficiency and ammonia excess also occur. These disorders are citrullinemia, argininosuccinic aciduria, and argininemia. In the presence of excessive lysine the availability of arginine is reduced and the formati …
In three of the inherited urea cycle disorders, ornithine insufficiency and ammonia excess also occur. These disorders are citrullinemia, ar …
Diagnostic value of urinary orotic acid levels: applicable separation methods.
Salerno C, Crifò C. Salerno C, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Dec 5;781(1-2):57-71. doi: 10.1016/s1570-0232(02)00533-0. J Chromatogr B Analyt Technol Biomed Life Sci. 2002. PMID: 12450653 Review.
Urinary orotic acid determination is a useful tool for screening hereditary orotic aciduria and for differentiating the hyperammonemia disorders which cannot be readily diagnosed by amino acid chromatography, thus reducing the need for enzyme determination in …
Urinary orotic acid determination is a useful tool for screening hereditary orotic aciduria and for differentiating the …
21 results