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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1971 1
1976 1
1977 1
1978 3
1985 2
1986 1
1987 2
1988 7
1989 3
1990 4
1991 4
1992 9
1993 10
1994 16
1995 11
1996 8
1997 7
1998 13
1999 16
2000 13
2001 23
2002 15
2003 9
2004 18
2005 12
2006 16
2007 13
2008 14
2009 18
2010 12
2011 14
2012 18
2013 18
2014 17
2015 23
2016 19
2017 18
2018 8
2019 21
2020 23
2021 18
2022 11
2023 9
2024 4

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472 results

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Page 1
Cowden syndrome and the PTEN hamartoma tumor syndrome: systematic review and revised diagnostic criteria.
Pilarski R, Burt R, Kohlman W, Pho L, Shannon KM, Swisher E. Pilarski R, et al. J Natl Cancer Inst. 2013 Nov 6;105(21):1607-16. doi: 10.1093/jnci/djt277. Epub 2013 Oct 17. J Natl Cancer Inst. 2013. PMID: 24136893 Review.
BACKGROUND: PTEN hamartoma tumor syndrome (PHTS) refers to a spectrum of disorders caused by mutations in the phosphatase and tensin homolog (PTEN) gene. Diagnostic criteria for Cowden syndrome, the principal PTEN-related disorder, …
BACKGROUND: PTEN hamartoma tumor syndrome (PHTS) refers to a spectrum of disorders caused by mutations in the ph …
The Clinical Spectrum of PTEN Mutations.
Yehia L, Keel E, Eng C. Yehia L, et al. Annu Rev Med. 2020 Jan 27;71:103-116. doi: 10.1146/annurev-med-052218-125823. Epub 2019 Aug 21. Annu Rev Med. 2020. PMID: 31433956 Review.
PTEN is a tumor suppressor gene that classically dampens the PI3K/AKT/mTOR growth-promoting signaling cascade. ...Hence, the umbrella term of PTEN hamartoma tumor syndrome (PHTS) was coined. Timely diagnosis and understanding the natural …
PTEN is a tumor suppressor gene that classically dampens the PI3K/AKT/mTOR growth-promoting signaling cascade. ...Hence, the u …
ACG clinical guideline: Genetic testing and management of hereditary gastrointestinal cancer syndromes.
Syngal S, Brand RE, Church JM, Giardiello FM, Hampel HL, Burt RW; American College of Gastroenterology. Syngal S, et al. Am J Gastroenterol. 2015 Feb;110(2):223-62; quiz 263. doi: 10.1038/ajg.2014.435. Epub 2015 Feb 3. Am J Gastroenterol. 2015. PMID: 25645574 Free PMC article. Review.
Genetic testing should be conducted in the context of pre- and post-test genetic counseling to ensure the patient's informed decision making. Patients who meet clinical criteria for a syndrome as well as those with identified pathogenic germline mutations should receive ap …
Genetic testing should be conducted in the context of pre- and post-test genetic counseling to ensure the patient's informed decision making …
Pathology and genetics of hereditary colorectal cancer.
Ma H, Brosens LAA, Offerhaus GJA, Giardiello FM, de Leng WWJ, Montgomery EA. Ma H, et al. Pathology. 2018 Jan;50(1):49-59. doi: 10.1016/j.pathol.2017.09.004. Epub 2017 Nov 21. Pathology. 2018. PMID: 29169633 Review.
Between 2 and 5% of all CRCs occur due to inherited syndromes, including Lynch syndrome, familial adenomatous polyposis, MUTYH-associated polyposis, Peutz-Jeghers syndrome, juvenile polyposis and Cowden/PTEN hamartoma syndrome. In addition, serr …
Between 2 and 5% of all CRCs occur due to inherited syndromes, including Lynch syndrome, familial adenomatous polyposis, MUTYH-associ …
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Familial Tumor Syndromes.
Nosé V, Lazar AJ. Nosé V, et al. Head Neck Pathol. 2022 Mar;16(1):143-157. doi: 10.1007/s12105-022-01414-z. Epub 2022 Mar 21. Head Neck Pathol. 2022. PMID: 35312981 Free PMC article. Review.
This review highlights the important findings within these syndromes, especially on the update on syndromes with tumors involving the head and neck region, as Gorlin syndrome/nevoid basal cell carcinoma syndrome associated with odontogenic keratocysts; Brooke-Spiegl …
This review highlights the important findings within these syndromes, especially on the update on syndromes with tumors involving the head a …
PTEN Hamartoma tumor syndrome in childhood: A review of the clinical literature.
Macken WL, Tischkowitz M, Lachlan KL. Macken WL, et al. Am J Med Genet C Semin Med Genet. 2019 Dec;181(4):591-610. doi: 10.1002/ajmg.c.31743. Epub 2019 Oct 14. Am J Med Genet C Semin Med Genet. 2019. PMID: 31609537 Review.
PTEN hamartoma tumor syndrome (PHTS) is a highly variable autosomal dominant condition associated with intellectual disability, overgrowth, and tumor predisposition phenotypes, which often overlap. PHTS incorporates a number of historical clinic …
PTEN hamartoma tumor syndrome (PHTS) is a highly variable autosomal dominant condition associated with intellect …
An update on the CNS manifestations of neurofibromatosis type 2.
Coy S, Rashid R, Stemmer-Rachamimov A, Santagata S. Coy S, et al. Acta Neuropathol. 2020 Apr;139(4):643-665. doi: 10.1007/s00401-019-02029-5. Epub 2019 Jun 4. Acta Neuropathol. 2020. PMID: 31161239 Free PMC article. Review.
Neurofibromatosis type II (NF2) is a tumor predisposition syndrome characterized by the development of distinctive nervous system lesions. ...NF2 has a highly variable clinical course, with some patients exhibiting a severe phenotype and development of multiple …
Neurofibromatosis type II (NF2) is a tumor predisposition syndrome characterized by the development of distinctive nervous sys …
PTEN hamartoma tumor syndrome: clinical risk assessment and management protocol.
Ngeow J, Eng C. Ngeow J, et al. Methods. 2015 May;77-78:11-9. doi: 10.1016/j.ymeth.2014.10.011. Epub 2014 Oct 22. Methods. 2015. PMID: 25461771 Review.
The tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is an important phosphatase that counteracts one of the most critical cancer pathways: the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathways. Clinically, deregulation of …
The tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is an important phosphatase that counterac …
A review on age-related cancer risks in PTEN hamartoma tumor syndrome.
Hendricks LAJ, Hoogerbrugge N, Schuurs-Hoeijmakers JHM, Vos JR. Hendricks LAJ, et al. Clin Genet. 2021 Feb;99(2):219-225. doi: 10.1111/cge.13875. Epub 2020 Nov 16. Clin Genet. 2021. PMID: 33140411 Free PMC article. Review.
Patients with PTEN hamartoma tumor syndrome (PHTS, comprising Cowden, Bannayan-Riley-Ruvalcaba, and Proteus-like syndromes) are at increased risk of developing cancer due to pathogenic PTEN germline variants. ...The median age at diagnosis was 3 …
Patients with PTEN hamartoma tumor syndrome (PHTS, comprising Cowden, Bannayan-Riley-Ruvalcaba, and Proteus-like …
PTEN hamartoma tumor syndrome.
Mester J, Charis E. Mester J, et al. Handb Clin Neurol. 2015;132:129-37. doi: 10.1016/B978-0-444-62702-5.00009-3. Handb Clin Neurol. 2015. PMID: 26564076 Review.
PTEN hamartoma tumor syndrome (PHTS) is the molecular diagnostic term describing patients with Cowden syndrome, Bannayan-Riley-Ruvalcaba syndrome, and other clinical presentations with germline mutation of the PTEN tumor sup …
PTEN hamartoma tumor syndrome (PHTS) is the molecular diagnostic term describing patients with Cowden syndrom …
472 results