Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1990 1
1994 1
1999 1
2003 1
2006 1
2011 1
2012 1
2013 2
2014 1
2015 3
2016 1
2018 1
2019 2
2020 1
2021 1
2023 1
2024 0

Text availability

Article attribute

Article type

Publication date

Search Results

17 results

Results by year

Filters applied: . Clear all
Page 1
Pancreatic alpha-cell hyperplasia: facts and myths.
Yu R. Yu R. J Clin Endocrinol Metab. 2014 Mar;99(3):748-56. doi: 10.1210/jc.2013-2952. Epub 2013 Nov 27. J Clin Endocrinol Metab. 2014. PMID: 24285676 Review.
CONTEXT: Pancreatic alpha-cell hyperplasia (ACH) was once an esoteric pathological entity, but it has become an important differential diagnosis of hyperglucagonemia after inactivating glucagon receptor (GCGR) genomic mutations were found in patients w …
CONTEXT: Pancreatic alpha-cell hyperplasia (ACH) was once an esoteric pathological entity, but it has become an …
Pathologic pancreatic endocrine cell hyperplasia.
Ouyang D, Dhall D, Yu R. Ouyang D, et al. World J Gastroenterol. 2011 Jan 14;17(2):137-43. doi: 10.3748/wjg.v17.i2.137. World J Gastroenterol. 2011. PMID: 21245985 Free PMC article. Review.
Pathologic hyperplasia of various pancreatic endocrine cells is rare but has been long known. beta cell hyperplasia contributes to persistent hyperinsulinemic hypoglycemia of infancy, which is commonly caused by mutations in the islet ATP-sensit …
Pathologic hyperplasia of various pancreatic endocrine cells is rare but has been long known. beta cell hyper …
Glucagon receptor signaling in metabolic diseases.
Wewer Albrechtsen NJ. Wewer Albrechtsen NJ. Peptides. 2018 Feb;100:42-47. doi: 10.1016/j.peptides.2017.11.016. Peptides. 2018. PMID: 29412830 Review.
Glucagon is a peptide hormone secreted from the pancreatic alpha cells in response to hypoglycemia but in some patients with type 2 diabetes a paradoxical hypersecretion results from the intake of glucose. ...Although the reported increases of liver enzymes, …
Glucagon is a peptide hormone secreted from the pancreatic alpha cells in response to hypoglycemia but in some patients …
Glucagon cell hyperplasia and neoplasia: a recently recognized endocrine receptor disease.
Sipos B, Klöppel G. Sipos B, et al. Endocr Relat Cancer. 2023 Jul 18;30(8):e230032. doi: 10.1530/ERC-23-0032. Print 2023 Aug 1. Endocr Relat Cancer. 2023. PMID: 37260318 Review.
Glucagon cell hyperplasia and neoplasia (GCHN) is the name of an endocrine receptor disease, whose morphology was first described in 2006. ...Recent results of several studies in GCGR knockout mice suggested that elevated serum amino acid levels probably stimulate g …
Glucagon cell hyperplasia and neoplasia (GCHN) is the name of an endocrine receptor disease, whose morphology was first descri …
Evolving function and potential of pancreatic alpha cells.
Stanojevic V, Habener JF. Stanojevic V, et al. Best Pract Res Clin Endocrinol Metab. 2015 Dec;29(6):859-71. doi: 10.1016/j.beem.2015.10.002. Epub 2015 Oct 8. Best Pract Res Clin Endocrinol Metab. 2015. PMID: 26696515 Free PMC article. Review.
Impairment of glucagon signaling both prevents the occurrence of diabetes in conditions of the near absence of insulin and expands alpha cell mass. Alpha cells appear to serve as helper cells or guardians of beta cells to ensure their hea …
Impairment of glucagon signaling both prevents the occurrence of diabetes in conditions of the near absence of insulin and expands alpha …
The Role of the alpha Cell in the Pathogenesis of Diabetes: A World beyond the Mirror.
Martínez MS, Manzano A, Olivar LC, Nava M, Salazar J, D'Marco L, Ortiz R, Chacín M, Guerrero-Wyss M, Cabrera de Bravo M, Cano C, Bermúdez V, Angarita L. Martínez MS, et al. Int J Mol Sci. 2021 Sep 1;22(17):9504. doi: 10.3390/ijms22179504. Int J Mol Sci. 2021. PMID: 34502413 Free PMC article. Review.
This phenomenon has been attributed to intra-islet defects, like modifications in pancreatic alpha cell mass or dysfunction in glucagon's secretion. Emerging evidence has shown that chronic hyperglycaemia provokes changes in the Langerhans' islets cytoarchite …
This phenomenon has been attributed to intra-islet defects, like modifications in pancreatic alpha cell mass or dysfunc …
A Primary Role for alpha-Cells as Amino Acid Sensors.
Dean ED. Dean ED. Diabetes. 2020 Apr;69(4):542-549. doi: 10.2337/dbi19-0021. Epub 2019 Oct 25. Diabetes. 2020. PMID: 31653720 Free PMC article. Review.
Interrupting glucagon signaling lowers blood glucose but also results in hyperglucagonemia and alpha-cell hyperplasia. Investigation of the mechanism for alpha-cell proliferation led to the description of a conserved liver-alpha-cell …
Interrupting glucagon signaling lowers blood glucose but also results in hyperglucagonemia and alpha-cell hyperplasia. …
Alpha cells come of age.
Habener JF, Stanojevic V. Habener JF, et al. Trends Endocrinol Metab. 2013 Mar;24(3):153-63. doi: 10.1016/j.tem.2012.10.009. Epub 2012 Dec 21. Trends Endocrinol Metab. 2013. PMID: 23260869 Review.
The alpha cells that coinhabit the islets with the insulin-producing beta cells have recently captured the attention of diabetes researchers because of new breakthrough findings highlighting the importance of these cells in the maintenance of beta c …
The alpha cells that coinhabit the islets with the insulin-producing beta cells have recently captured the attention of …
beta-Cell Fate in Human Insulin Resistance and Type 2 Diabetes: A Perspective on Islet Plasticity.
Mezza T, Cinti F, Cefalo CMA, Pontecorvi A, Kulkarni RN, Giaccari A. Mezza T, et al. Diabetes. 2019 Jun;68(6):1121-1129. doi: 10.2337/db18-0856. Diabetes. 2019. PMID: 31109941 Free PMC article. Review.
Although it is well established that type 2 diabetes (T2D) is generally due to the progressive loss of beta-cell insulin secretion against a background of insulin resistance, the actual correlation of reduced beta-cell mass to its defective function continues to be …
Although it is well established that type 2 diabetes (T2D) is generally due to the progressive loss of beta-cell insulin secretion ag …
Inhibiting or antagonizing glucagon: making progress in diabetes care.
Lefèbvre PJ, Paquot N, Scheen AJ. Lefèbvre PJ, et al. Diabetes Obes Metab. 2015 Aug;17(8):720-5. doi: 10.1111/dom.12480. Epub 2015 May 28. Diabetes Obes Metab. 2015. PMID: 25924114 Review.
It has been suggested that excess secretion of glucagon by the islet alpha cells is a direct consequence of intra-islet insulin secretory defects. ...The potential risks associated with total glucagon suppression include alpha-cell hyperplasia, …
It has been suggested that excess secretion of glucagon by the islet alpha cells is a direct consequence of intra-islet insuli …
17 results