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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1987 1
1988 2
1989 1
1991 6
1992 1
1993 6
1994 3
1995 2
1996 3
1997 3
1998 5
1999 6
2000 15
2001 7
2002 2
2003 9
2004 4
2005 8
2006 8
2007 7
2008 5
2009 10
2010 13
2011 11
2012 19
2013 13
2014 12
2015 22
2016 21
2017 10
2018 25
2019 17
2020 26
2021 20
2022 8
2023 3
2024 2

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295 results

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Page 1
Sirt1 and the Mitochondria.
Tang BL. Tang BL. Mol Cells. 2016 Feb;39(2):87-95. doi: 10.14348/molcells.2016.2318. Epub 2016 Feb 2. Mol Cells. 2016. PMID: 26831453 Free PMC article. Review.
Although primarily a nuclear protein, Sirt1's deacetylation of Peroxisome proliferator-activated receptor Gamma Coactivator-1alpha (PGC-1alpha) has been extensively implicated in metabolic control and mitochondrial biogenesis, which was proposed to partially underli …
Although primarily a nuclear protein, Sirt1's deacetylation of Peroxisome proliferator-activated receptor Gamma Coactivator-1alpha (P …
PGC-1alpha: a key regulator of energy metabolism.
Liang H, Ward WF. Liang H, et al. Adv Physiol Educ. 2006 Dec;30(4):145-51. doi: 10.1152/advan.00052.2006. Adv Physiol Educ. 2006. PMID: 17108241 Free article. Review.
Peroxisome proliferator-activated receptor-gamma coactivator (PGC)-1alpha is a member of a family of transcription coactivators that plays a central role in the regulation of cellular energy metabolism. ...It is highly likely that PGC-1alpha is intimately involved in di …
Peroxisome proliferator-activated receptor-gamma coactivator (PGC)-1alpha is a member of a family of transcription coactivators that …
Peroxisome: Metabolic Functions and Biogenesis.
Okumoto K, Tamura S, Honsho M, Fujiki Y. Okumoto K, et al. Adv Exp Med Biol. 2020;1299:3-17. doi: 10.1007/978-3-030-60204-8_1. Adv Exp Med Biol. 2020. PMID: 33417203 Review.
Such metabolic functions and the exclusive importance of peroxisomes have been highlighted in fatal human genetic disease called peroxisomal biogenesis disorders (PBDs). Recent advances in this field have identified over 30 PEX genes encoding pe …
Such metabolic functions and the exclusive importance of peroxisomes have been highlighted in fatal human genetic disease call …
Mitochondrial energetics in the kidney.
Bhargava P, Schnellmann RG. Bhargava P, et al. Nat Rev Nephrol. 2017 Oct;13(10):629-646. doi: 10.1038/nrneph.2017.107. Epub 2017 Aug 14. Nat Rev Nephrol. 2017. PMID: 28804120 Free PMC article. Review.
Mitochondria provide the energy to drive these important functions and can adapt to different metabolic conditions through a number of signalling pathways (for example, mechanistic target of rapamycin (mTOR) and AMP-activated protein kinase (AMPK) pathways) that activate the tran …
Mitochondria provide the energy to drive these important functions and can adapt to different metabolic conditions through a number of signa …
The menage a trois of autophagy, lipid droplets and liver disease.
Filali-Mouncef Y, Hunter C, Roccio F, Zagkou S, Dupont N, Primard C, Proikas-Cezanne T, Reggiori F. Filali-Mouncef Y, et al. Autophagy. 2022 Jan;18(1):50-72. doi: 10.1080/15548627.2021.1895658. Epub 2021 Apr 2. Autophagy. 2022. PMID: 33794741 Free PMC article. Review.
Here we provide an overview on our current knowledge of the biogenesis and functions of LDs, and the mechanisms underlying their lysosomal turnover by autophagic processes. ...Particular attention is paid to the role of macroautophagy and macrolipophagy in relation to the …
Here we provide an overview on our current knowledge of the biogenesis and functions of LDs, and the mechanisms underlying their lyso …
The physiological functions of human peroxisomes.
Wanders RJA, Baes M, Ribeiro D, Ferdinandusse S, Waterham HR. Wanders RJA, et al. Physiol Rev. 2023 Jan 1;103(1):957-1024. doi: 10.1152/physrev.00051.2021. Epub 2022 Aug 11. Physiol Rev. 2023. PMID: 35951481 Free article. Review.
Among others these include the Zellweger spectrum disorders, X-linked adrenoleukodystrophy, and Refsum disease. To fulfill their role in metabolism, peroxisomes require continued interaction with other subcellular organelles including lipid droplets, lysosome …
Among others these include the Zellweger spectrum disorders, X-linked adrenoleukodystrophy, and Refsum disease. To fulfill the …
Mitochondrial biogenesis in neurodegeneration.
Li PA, Hou X, Hao S. Li PA, et al. J Neurosci Res. 2017 Oct;95(10):2025-2029. doi: 10.1002/jnr.24042. Epub 2017 Mar 16. J Neurosci Res. 2017. PMID: 28301064 Review.
Therefore, preserving or promoting mitochondrial function is a potential therapeutic target for the treatment of neurodegenerative disorders. Mitochondrial biogenesis is a process by which new mitochondria are produced from existing mitochondria. This biogenesis …
Therefore, preserving or promoting mitochondrial function is a potential therapeutic target for the treatment of neurodegenerative disord …
Molecular Mechanisms of Muscle Fatigue.
Constantin-Teodosiu D, Constantin D. Constantin-Teodosiu D, et al. Int J Mol Sci. 2021 Oct 27;22(21):11587. doi: 10.3390/ijms222111587. Int J Mol Sci. 2021. PMID: 34769017 Free PMC article. Review.
The leading cause underpinning the development of chronic fatigue is related to muscle wasting mediated by aging, immobilization, insulin resistance (through high-fat dietary intake or pharmacologically mediated Peroxisome Proliferator-Activated Receptor (PPAR) agonism), d …
The leading cause underpinning the development of chronic fatigue is related to muscle wasting mediated by aging, immobilization, insulin re …
The CD36-PPARgamma Pathway in Metabolic Disorders.
Maréchal L, Laviolette M, Rodrigue-Way A, Sow B, Brochu M, Caron V, Tremblay A. Maréchal L, et al. Int J Mol Sci. 2018 May 21;19(5):1529. doi: 10.3390/ijms19051529. Int J Mol Sci. 2018. PMID: 29883404 Free PMC article. Review.
Uncovering the biological role of nuclear receptor peroxisome proliferator-activated receptors (PPARs) has greatly advanced our knowledge of the transcriptional control of glucose and energy metabolism. ...The identification of the GHRP-CD36-PPARgamma pathway in controllin …
Uncovering the biological role of nuclear receptor peroxisome proliferator-activated receptors (PPARs) has greatly advanced our knowl …
The Role of PGC-1alpha and Mitochondrial Biogenesis in Kidney Diseases.
Fontecha-Barriuso M, Martin-Sanchez D, Martinez-Moreno JM, Monsalve M, Ramos AM, Sanchez-Niño MD, Ruiz-Ortega M, Ortiz A, Sanz AB. Fontecha-Barriuso M, et al. Biomolecules. 2020 Feb 24;10(2):347. doi: 10.3390/biom10020347. Biomolecules. 2020. PMID: 32102312 Free PMC article. Review.
: Chronic kidney disease (CKD) is one of the fastest growing causes of death worldwide, emphasizing the need to develop novel therapeutic approaches. ...Mitochondrial derangements are common features of both AKI and CKD and mitochondria-targeting therapies are under study …
: Chronic kidney disease (CKD) is one of the fastest growing causes of death worldwide, emphasizing the need to develop novel therape …
295 results