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Refractory Pit1 plurihormonal tumours and thyrotroph adenomas.
Nf L, Ai M. Nf L, et al. Pituitary. 2023 Apr;26(2):182-186. doi: 10.1007/s11102-023-01312-9. Epub 2023 Apr 29. Pituitary. 2023. PMID: 37117845 Free PMC article. Review.
Pit-1 tumours are derived from neoplastic cells of either somatotroph, lactotroph or thyrotroph cell lineages, but there are also distinct mixed tumours and plurihormonal tumours within this category as described within the 2022 edition of the WHO classification of pitu …
Pit-1 tumours are derived from neoplastic cells of either somatotroph, lactotroph or thyrotroph cell lineages, but there are also dis …
Pituitary Hyperplasia, Hormonal Changes and Prolactinoma Development in Males Exposed to Estrogens-An Insight From Translational Studies.
Šošić-Jurjević B, Ajdžanović V, Miljić D, Trifunović S, Filipović B, Stanković S, Bolevich S, Jakovljević V, Milošević V. Šošić-Jurjević B, et al. Int J Mol Sci. 2020 Mar 16;21(6):2024. doi: 10.3390/ijms21062024. Int J Mol Sci. 2020. PMID: 32188093 Free PMC article. Review.
Estrogen signaling plays an important role in pituitary development and function. In sensitive rat or mice strains of both sexes, estrogen treatments promote lactotropic cell proliferation and induce the formation of pituitary adenomas (dominantly prol …
Estrogen signaling plays an important role in pituitary development and function. In sensitive rat or mice strains of both sexes, est …
The role of Notch and Hedgehog signaling pathways in pituitary development and pathogenesis of pituitary adenomas.
Yavropoulou MP, Maladaki A, Yovos JG. Yavropoulou MP, et al. Hormones (Athens). 2015 Jan-Mar;14(1):5-18. doi: 10.1007/BF03401377. Hormones (Athens). 2015. PMID: 25885100 Free article. Review.
A large diversity of pathogenetic mechanisms has been described so far including deregulation of cell cycle, molecular pathways and angiogenesis. Major signaling pathways such as Notch, Wnt and Hedgehog, which are mainly active in the early phase of pituitary organo …
A large diversity of pathogenetic mechanisms has been described so far including deregulation of cell cycle, molecular pathways and a …
Silent adenoma subtype 3 of the pituitary--immunohistochemical and ultrastructural classification: a review of 29 cases.
Horvath E, Kovacs K, Smyth HS, Cusimano M, Singer W. Horvath E, et al. Ultrastruct Pathol. 2005 Nov-Dec;29(6):511-24. doi: 10.1080/01913120500323514. Ultrastruct Pathol. 2005. PMID: 16316952 Review.
The silent adenoma subtype 3 (SAS-3) of undetermined cellular derivation is a seemingly nonfunctioning aggressive pituitary tumor with a high recurrence rate. ...The 100- to 200-nm secretory granules accumulate heavily in cell processes, which is a hallmark o …
The silent adenoma subtype 3 (SAS-3) of undetermined cellular derivation is a seemingly nonfunctioning aggressive pituitary tu …
Molecular determinants of pituitary cytodifferentiation.
Asa SL, Ezzat S. Asa SL, et al. Pituitary. 1999 May;1(3-4):159-68. doi: 10.1023/a:1009948813587. Pituitary. 1999. PMID: 11081194 Review.
The pituitary is a complex gland and is composed of several cell types, each responsible for the production of specific hormones. ...Plurihormonal adenomas were thought to be either composed of multiple cell types, each producing one hormone (plurimorp …
The pituitary is a complex gland and is composed of several cell types, each responsible for the production of specific hormon …
Role of regulatory factors in pituitary tumour formation.
Korbonits M, Morris DG, Nanzer A, Kola B, Grossman AB. Korbonits M, et al. Front Horm Res. 2004;32:63-95. doi: 10.1159/000079038. Front Horm Res. 2004. PMID: 15281340 Review.
Animal models also provide data that in the presence of excessive hypothalamic hormone stimulation, adenoma formation can occur. However, evidence in favour of the monoclonal nature of pituitary tumours argues for an intrinsic molecular defect as the primary initiat …
Animal models also provide data that in the presence of excessive hypothalamic hormone stimulation, adenoma formation can occur. Howe …
Hypothalamic thyrotropin-releasing hormone and thyrotropin biological activity.
Persani L. Persani L. Thyroid. 1998 Oct;8(10):941-6. doi: 10.1089/thy.1998.8.941. Thyroid. 1998. PMID: 9827663 Review.
TRH action affects various steps of the biosynthetic process within thyrotrophs, with major effects on the posttranslational maturation of TSH oligosaccharide chains, and is necessary for the secretion of the glycoprotein hormone with full biological activity. ...Data obta …
TRH action affects various steps of the biosynthetic process within thyrotrophs, with major effects on the posttranslational maturati …
[TSH-secreting pituitary tumors: two case reports and literature review].
Duarte FH, Jallad RS, Salgado LR, Bronstein MD. Duarte FH, et al. Arq Bras Endocrinol Metabol. 2009 Dec;53(9):1157-66. doi: 10.1590/s0004-27302009000900013. Arq Bras Endocrinol Metabol. 2009. PMID: 20126874 Review. Portuguese.
INTRODUCTION: TSH-secreting pituitary adenomas are rare pituitary functioning tumors accounting for less than 2% of the pituitary adenomas. ...CONCLUSION: In the presence of elevated thyroid hormone levels associated with inappropriate normal or …
INTRODUCTION: TSH-secreting pituitary adenomas are rare pituitary functioning tumors accounting for less than 2% of the …