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The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary.
Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P, Ellison DW. Louis DN, et al. Acta Neuropathol. 2016 Jun;131(6):803-20. doi: 10.1007/s00401-016-1545-1. Epub 2016 May 9. Acta Neuropathol. 2016. PMID: 27157931 Review.
As such, the 2016 CNS WHO presents major restructuring of the diffuse gliomas, medulloblastomas and other embryonal tumors, and incorporates new entities that are defined by both histology and molecular features, including glioblastoma, IDH-wildtype and glioblastoma, IDH-mutant; …
As such, the 2016 CNS WHO presents major restructuring of the diffuse gliomas, medulloblastomas and other embryonal tumors, and incorporates …
WHO 2016 Classification of gliomas.
Wesseling P, Capper D. Wesseling P, et al. Neuropathol Appl Neurobiol. 2018 Feb;44(2):139-150. doi: 10.1111/nan.12432. Neuropathol Appl Neurobiol. 2018. PMID: 28815663 Review.
The most important changes in the very diverse group of 'nondiffuse' gliomas and neuronal-glial tumours are the introduction of anaplastic pleomorphic xanthoastrocytoma, of diffuse leptomeningeal glioneuronal tumour and of RELA fusion-positive ependymoma
The most important changes in the very diverse group of 'nondiffuse' gliomas and neuronal-glial tumours are the introduction of anaplastic p …
Molecular pathology of tumors of the central nervous system.
Kristensen BW, Priesterbach-Ackley LP, Petersen JK, Wesseling P. Kristensen BW, et al. Ann Oncol. 2019 Aug 1;30(8):1265-1278. doi: 10.1093/annonc/mdz164. Ann Oncol. 2019. PMID: 31124566 Free PMC article. Review.
Molecular characteristics are also important for the diagnosis of several other CNS tumors, such as RELA fusion-positive subtype of ependymoma, atypical teratoid rhabdoid tumor (AT/RT), embryonal tumor with multilayered rosettes, and solitary fibrous t …
Molecular characteristics are also important for the diagnosis of several other CNS tumors, such as RELA fusion-positive
Ependymomas.
Bertero L, Ricci AA, Tampieri C, Cassoni P, Modena P. Bertero L, et al. Pathologica. 2022 Dec;114(6):436-446. doi: 10.32074/1591-951X-817. Pathologica. 2022. PMID: 36534422 Free PMC article. Review.
The recently published 5th edition of WHO Classification of Central Nervous System Tumours integrates this novel knowledge and represents a substantial update compared to the previous edition. Concerning supratentorial ependymomas, the previous RELA fusion- …
The recently published 5th edition of WHO Classification of Central Nervous System Tumours integrates this novel knowledge and represents a …
Supratentorial pediatric cortical ependymomas: a comprehensive retrospective study.
Wang Q, Cheng J, Zhang S, Li Q, Hui X, Ju Y. Wang Q, et al. Neurosurg Rev. 2021 Jun;44(3):1543-1551. doi: 10.1007/s10143-020-01336-w. Epub 2020 Jun 30. Neurosurg Rev. 2021. PMID: 32607870 Review.
Pediatric cortical ependymomas (CEs) are rare; the clinical features and optimal treatment remain ill-defined. ...Five continuous patients in our series screened for C11orf95-RELA fusion and all the patients (100%) were RELA fusion positive. Fou …
Pediatric cortical ependymomas (CEs) are rare; the clinical features and optimal treatment remain ill-defined. ...Five continuous pat …
Molecular pathology of paediatric central nervous system tumours.
Chiang JC, Ellison DW. Chiang JC, et al. J Pathol. 2017 Jan;241(2):159-172. doi: 10.1002/path.4813. Epub 2016 Nov 10. J Pathol. 2017. PMID: 27701736 Review.
In this article, we review molecular genetic alterations in paediatric CNS tumours, including those in low-grade and high-grade gliomas, ependymomas, and embryonal tumours. Some of these molecular changes with clinicopathological utility have been used for the first time i …
In this article, we review molecular genetic alterations in paediatric CNS tumours, including those in low-grade and high-grade gliomas, …
Ependymal Tumors: Overview of the Recent World Health Organization Histopathologic and Genetic Updates with an Imaging Characteristic.
Soni N, Ora M, Bathla G, Desai A, Gupta V, Agarwal A. Soni N, et al. AJNR Am J Neuroradiol. 2024 Nov 7;45(11):1624-1634. doi: 10.3174/ajnr.A8237. AJNR Am J Neuroradiol. 2024. PMID: 38844368 Review.
Supratentorial tumors are defined by zinc finger translocation associated (ZFTA) (formerly v-rel avian reticuloendotheliosis viral oncogene [RELA]), or yes-associated protein 1 (YAP1) fusion; posterior fossa tumors are classified into groups A (PFA) and B (PFB), spinal …
Supratentorial tumors are defined by zinc finger translocation associated (ZFTA) (formerly v-rel avian reticuloendotheliosis viral oncogene …
The 2016 WHO Classification of Tumours of the Central Nervous System: The Major Points of Revision.
Komori T. Komori T. Neurol Med Chir (Tokyo). 2017 Jul 15;57(7):301-311. doi: 10.2176/nmc.ra.2017-0010. Epub 2017 Jun 8. Neurol Med Chir (Tokyo). 2017. PMID: 28592714 Free PMC article. Review.
New entities that are defined by both the histological and molecular features include glioblastoma, isocitrate dehydrogenase (IDH)-wildtype and glioblastoma, IDH-mutant; diffuse midline glioma, H3 K27M-mutant; RELA fusion-positive ependymoma; medullobl …
New entities that are defined by both the histological and molecular features include glioblastoma, isocitrate dehydrogenase (IDH)-wildtype …