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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1972 1
1973 1
1974 2
1977 1
1980 2
1981 1
1982 3
1983 1
1984 2
1985 3
1986 3
1987 5
1988 2
1989 2
1990 5
1991 6
1992 3
1993 1
1994 4
1995 5
1996 3
1997 5
1998 2
1999 3
2000 3
2001 4
2002 6
2003 13
2004 4
2005 6
2006 10
2007 4
2008 8
2009 9
2010 11
2011 17
2012 20
2013 27
2014 22
2015 21
2016 33
2017 29
2018 32
2019 32
2020 44
2021 43
2022 55
2023 43
2024 13

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511 results

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Page 1
Chronic inflammation in the etiology of disease across the life span.
Furman D, Campisi J, Verdin E, Carrera-Bastos P, Targ S, Franceschi C, Ferrucci L, Gilroy DW, Fasano A, Miller GW, Miller AH, Mantovani A, Weyand CM, Barzilai N, Goronzy JJ, Rando TA, Effros RB, Lucia A, Kleinstreuer N, Slavich GM. Furman D, et al. Nat Med. 2019 Dec;25(12):1822-1832. doi: 10.1038/s41591-019-0675-0. Epub 2019 Dec 5. Nat Med. 2019. PMID: 31806905 Free PMC article. Review.
Although intermittent increases in inflammation are critical for survival during physical injury and infection, recent research has revealed that certain social, environmental and lifestyle factors can promote systemic chronic inflammation (SCI) that can, in turn, lead to several …
Although intermittent increases in inflammation are critical for survival during physical injury and infection, recent research has revealed …
Insulin resistance and insulin sensitizing agents.
Mastrototaro L, Roden M. Mastrototaro L, et al. Metabolism. 2021 Dec;125:154892. doi: 10.1016/j.metabol.2021.154892. Epub 2021 Sep 23. Metabolism. 2021. PMID: 34563556 Free article. Review.
Specifically, the severe insulin resistant diabetes (SIRD) subtype not only exhibits metabolic abnormalities, but also bears a higher risk for cardiovascular, renal and hepatic comorbidities. In humans, insulin resistance comprises dysfunctional adipose tissue, lipotoxic i …
Specifically, the severe insulin resistant diabetes (SIRD) subtype not only exhibits metabolic abnormalities, but also bears a higher risk f …
Ferroptosis and Liver Fibrosis.
Pan Q, Luo Y, Xia Q, He K. Pan Q, et al. Int J Med Sci. 2021 Jul 25;18(15):3361-3366. doi: 10.7150/ijms.62903. eCollection 2021. Int J Med Sci. 2021. PMID: 34522161 Free PMC article. Review.
A number of studies have indicated that ferroptosis is closely associated with acute renal failure, tumor, ischemia and reperfusion injury, neurodegenerative diseases and liver fibrosis. Liver fibrosis, which has long been a global health problem, still lacks …
A number of studies have indicated that ferroptosis is closely associated with acute renal failure, tumor, ischemia and reperfusion i …
Kidney lipid dysmetabolism and lipid droplet accumulation in chronic kidney disease.
Mitrofanova A, Merscher S, Fornoni A. Mitrofanova A, et al. Nat Rev Nephrol. 2023 Oct;19(10):629-645. doi: 10.1038/s41581-023-00741-w. Epub 2023 Jul 27. Nat Rev Nephrol. 2023. PMID: 37500941 Review.
Among several pathogenetic mechanisms responsible for disease progression, lipid accumulation in the kidney parenchyma might drive inflammation and fibrosis, as has been described in fatty liver diseases. Lipids and their metabolites have several important structura …
Among several pathogenetic mechanisms responsible for disease progression, lipid accumulation in the kidney parenchyma might drive inflammat …
Preeclampsia and eclampsia: the conceptual evolution of a syndrome.
Erez O, Romero R, Jung E, Chaemsaithong P, Bosco M, Suksai M, Gallo DM, Gotsch F. Erez O, et al. Am J Obstet Gynecol. 2022 Feb;226(2S):S786-S803. doi: 10.1016/j.ajog.2021.12.001. Am J Obstet Gynecol. 2022. PMID: 35177220 Free PMC article. Review.
A subset of patients diagnosed with preeclampsia are at greater risk of the subsequent development of hypertension, ischemic heart disease, heart failure, vascular dementia, and end-stage renal disease. However, these adverse events may be the result of a preexisting vascu …
A subset of patients diagnosed with preeclampsia are at greater risk of the subsequent development of hypertension, ischemic heart disease, …
Psoriasis and comorbid diseases: Epidemiology.
Takeshita J, Grewal S, Langan SM, Mehta NN, Ogdie A, Van Voorhees AS, Gelfand JM. Takeshita J, et al. J Am Acad Dermatol. 2017 Mar;76(3):377-390. doi: 10.1016/j.jaad.2016.07.064. J Am Acad Dermatol. 2017. PMID: 28212759 Free PMC article. Review.
Fructose and sugar: A major mediator of non-alcoholic fatty liver disease.
Jensen T, Abdelmalek MF, Sullivan S, Nadeau KJ, Green M, Roncal C, Nakagawa T, Kuwabara M, Sato Y, Kang DH, Tolan DR, Sanchez-Lozada LG, Rosen HR, Lanaspa MA, Diehl AM, Johnson RJ. Jensen T, et al. J Hepatol. 2018 May;68(5):1063-1075. doi: 10.1016/j.jhep.2018.01.019. Epub 2018 Feb 2. J Hepatol. 2018. PMID: 29408694 Free PMC article. Review.
Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome; its rising prevalence parallels the rise in obesity and diabetes. ...Recent evidence suggests that the predisposition to fatty liver is linked to the metaboli …
Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome; its rising prevalence parallels …
Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities.
Opazo-Ríos L, Mas S, Marín-Royo G, Mezzano S, Gómez-Guerrero C, Moreno JA, Egido J. Opazo-Ríos L, et al. Int J Mol Sci. 2020 Apr 10;21(7):2632. doi: 10.3390/ijms21072632. Int J Mol Sci. 2020. PMID: 32290082 Free PMC article. Review.
Lipotoxicity is mainly associated with dysfunctional signaling and insulin resistance response in non-adipose tissue such as myocardium, pancreas, skeletal muscle, liver, and kidney. Serum lipid abnormalities and renal ectopic lipid accumulation have been associated …
Lipotoxicity is mainly associated with dysfunctional signaling and insulin resistance response in non-adipose tissue such as myocardium, pan …
Fructose and hepatic insulin resistance.
Softic S, Stanhope KL, Boucher J, Divanovic S, Lanaspa MA, Johnson RJ, Kahn CR. Softic S, et al. Crit Rev Clin Lab Sci. 2020 Aug;57(5):308-322. doi: 10.1080/10408363.2019.1711360. Epub 2020 Jan 14. Crit Rev Clin Lab Sci. 2020. PMID: 31935149 Free PMC article. Review.
Excessive caloric intake in a form of high-fat diet (HFD) was long thought to be the major risk factor for development of obesity and its complications, such as fatty liver disease and insulin resistance. Recently, there has been a paradigm shift and more attention …
Excessive caloric intake in a form of high-fat diet (HFD) was long thought to be the major risk factor for development of obesity and its co …
The fructose survival hypothesis for obesity.
Johnson RJ, Lanaspa MA, Sanchez-Lozada LG, Tolan D, Nakagawa T, Ishimoto T, Andres-Hernando A, Rodriguez-Iturbe B, Stenvinkel P. Johnson RJ, et al. Philos Trans R Soc Lond B Biol Sci. 2023 Sep 11;378(1885):20220230. doi: 10.1098/rstb.2022.0230. Epub 2023 Jul 24. Philos Trans R Soc Lond B Biol Sci. 2023. PMID: 37482773 Free PMC article. Review.
We propose excessive fructose metabolism not only explains obesity but the epidemics of diabetes, hypertension, non-alcoholic fatty liver disease, obesity-associated cancers, vascular and Alzheimer's dementia, and even ageing. ...
We propose excessive fructose metabolism not only explains obesity but the epidemics of diabetes, hypertension, non-alcoholic fatty …
511 results