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Asymmetric diabetic retinopathy.
Azad R, Sinha S, Nishant P. Azad R, et al. Indian J Ophthalmol. 2021 Nov;69(11):3026-3034. doi: 10.4103/ijo.IJO_1525_21. Indian J Ophthalmol. 2021. PMID: 34708738 Free PMC article. Review.
Asymmetric DR is defined as proliferative DR (PDR) in one eye and nonproliferative, preproliferative, background, or no DR in the other eye lasting for at least 2 years. It is observed in 5%-10% of patients with PDR. Associated factors can be divided into (i) vascular: car …
Asymmetric DR is defined as proliferative DR (PDR) in one eye and nonproliferative, preproliferative, background, or no DR in the other eye …
Nerve Growth Factor: Early Studies and Recent Clinical Trials.
Rocco ML, Soligo M, Manni L, Aloe L. Rocco ML, et al. Curr Neuropharmacol. 2018;16(10):1455-1465. doi: 10.2174/1570159X16666180412092859. Curr Neuropharmacol. 2018. PMID: 29651949 Free PMC article. Review.
These studies revealed that NGF possesses important therapeutic properties, after topical administration, on human cutaneous pressure ulcer, corneal ulcers, glaucoma, retinal maculopathy, Retinitis Pigmentosa and in pediatric optic gliomas and brain traumas. ...
These studies revealed that NGF possesses important therapeutic properties, after topical administration, on human cutaneous pressure ulcer, …
The genetic and phenotypic landscapes of Usher syndrome: from disease mechanisms to a new classification.
Delmaghani S, El-Amraoui A. Delmaghani S, et al. Hum Genet. 2022 Apr;141(3-4):709-735. doi: 10.1007/s00439-022-02448-7. Epub 2022 Mar 30. Hum Genet. 2022. PMID: 35353227 Free PMC article. Review.
Usher syndrome (USH) is the most common cause of deaf-blindness in humans, with a prevalence of about 1/10,000 (~ 400,000 people worldwide). Cochlear implants are currently used to reduce the burden of hearing loss in severe-to-profoundly deaf patients, but many promising …
Usher syndrome (USH) is the most common cause of deaf-blindness in humans, with a prevalence of about 1/10,000 (~ 400,000 people worl …
X-linked Retinitis Pigmentosa.
Tsang SH, Sharma T. Tsang SH, et al. Adv Exp Med Biol. 2018;1085:31-35. doi: 10.1007/978-3-319-95046-4_8. Adv Exp Med Biol. 2018. PMID: 30578481 Review.
X-linked retinitis pigmentosa (XLRP) is considered to be one of the most severe forms of retinitis pigmentosa (RP). It accounts for about 6-20% of all RP cases, including about 10% in the United States and 25% in England....
X-linked retinitis pigmentosa (XLRP) is considered to be one of the most severe forms of retinitis pigmentosa (R …
Ciliopathy: Usher Syndrome.
Tsang SH, Aycinena ARP, Sharma T. Tsang SH, et al. Adv Exp Med Biol. 2018;1085:167-170. doi: 10.1007/978-3-319-95046-4_32. Adv Exp Med Biol. 2018. PMID: 30578505 Review.
Because nearly every cell in the body (including the photoreceptors) contains cilia, defects in ciliary proteins typically affect multiple organ systems. Usher syndrome is the most common syndromic cause of retinitis pigmentosa (RP) and accounts for 10-20% of …
Because nearly every cell in the body (including the photoreceptors) contains cilia, defects in ciliary proteins typically affect multiple o …
MT-ATP6 mitochondrial disease variants: Phenotypic and biochemical features analysis in 218 published cases and cohort of 14 new cases.
Ganetzky RD, Stendel C, McCormick EM, Zolkipli-Cunningham Z, Goldstein AC, Klopstock T, Falk MJ. Ganetzky RD, et al. Hum Mutat. 2019 May;40(5):499-515. doi: 10.1002/humu.23723. Epub 2019 Mar 4. Hum Mutat. 2019. PMID: 30763462 Free PMC article. Review.
Despite extensive overlap in the heteroplasmy levels of MT-ATP6 variant carriers with and without a wide range of clinical symptoms, previously reported symptomatic subjects had significantly higher heteroplasmy load (p = 2.2 x 10(-16) ). Pathogenic MT-ATP6 variants result …
Despite extensive overlap in the heteroplasmy levels of MT-ATP6 variant carriers with and without a wide range of clinical symptoms, previou …
Sildenafil in ophthalmology: An update.
Arora S, Surakiatchanukul T, Arora T, Cagini C, Lupidi M, Chhablani J. Arora S, et al. Surv Ophthalmol. 2022 Mar-Apr;67(2):463-487. doi: 10.1016/j.survophthal.2021.06.004. Epub 2021 Jun 25. Surv Ophthalmol. 2022. PMID: 34175342 Review.
Sildenafil citrate, a selective oral phosphodiesterase 5 inhibitor, is a widely used drug for erectile dysfunction that acts by elevating cGMP levels and causing smooth muscle relaxation. It also has 10% activity against PDE6, a key enzyme in phototransduction cascade in t …
Sildenafil citrate, a selective oral phosphodiesterase 5 inhibitor, is a widely used drug for erectile dysfunction that acts by elevating cG …
Molecular Strategies for RPGR Gene Therapy.
Cehajic Kapetanovic J, McClements ME, Martinez-Fernandez de la Camara C, MacLaren RE. Cehajic Kapetanovic J, et al. Genes (Basel). 2019 Sep 4;10(9):674. doi: 10.3390/genes10090674. Genes (Basel). 2019. PMID: 31487940 Free PMC article. Review.
Mutations affecting the Retinitis Pigmentosa GTPase Regulator (RPGR) gene are the commonest cause of X-linked and recessive retinitis pigmentosa (RP), accounting for 10%-20% of all cases of RP. ...
Mutations affecting the Retinitis Pigmentosa GTPase Regulator (RPGR) gene are the commonest cause of X-linked and recessive …
Retinitis pigmentosa and other dystrophies.
Sahel J, Bonnel S, Mrejen S, Paques M. Sahel J, et al. Dev Ophthalmol. 2010;47:160-167. doi: 10.1159/000320079. Epub 2010 Aug 10. Dev Ophthalmol. 2010. PMID: 20703049 Review.
Retinitis pigmentosa (RP) is an inherited retinal degeneration that affects predominantly peripheral visual fields. ...Fluorescein angiography and/or optical coherence tomography detect the presence of macular edema in 10-20% of RP patients. Macular edema can …
Retinitis pigmentosa (RP) is an inherited retinal degeneration that affects predominantly peripheral visual fields. ...Fluores …
Cell Ferroptosis: New Mechanism and New Hope for Retinitis Pigmentosa.
Yang M, So KF, Lam WC, Lo ACY. Yang M, et al. Cells. 2021 Aug 21;10(8):2153. doi: 10.3390/cells10082153. Cells. 2021. PMID: 34440922 Free PMC article. Review.
Retinitis pigmentosa (RP) is a leading cause of inherited retinal degeneration, with more than 60 gene mutations. ...
Retinitis pigmentosa (RP) is a leading cause of inherited retinal degeneration, with more than 60 gene mutations. ...
107 results