H - Coenzyme transport and metabolism

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COG definitions	Organims	Proteins	Median Protein Length	Genes
258	2,294	391,169	296.0	250

Organism	Protein	COG	Cat	Annotation
1714	2498	COG0001	H	Glutamate-1-semialdehyde aminotransferase
1634	2474	COG0007	H	Uroporphyrinogen-III methylase (siroheme synthase)
705	797	COG0011	H	Thiamin-binding stress-response protein YqgV, UPF0045 family
1982	5797	COG0028	E H	Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme
1539	1704	COG0029	H	Aspartate oxidase
1098	1392	COG0043	H	3-polyprenyl-4-hydroxybenzoate decarboxylase
1934	2062	COG0054	H	6,7-dimethyl-8-ribityllumazine synthase (Riboflavin synthase beta chain)
1880	1948	COG0059	E H	Ketol-acid reductoisomerase
2178	2516	COG0061	H	NAD kinase
980	1511	COG0095	H	Lipoate-protein ligase A
1915	2165	COG0108	H	3,4-dihydroxy-2-butanone 4-phosphate synthase
1464	1584	COG0109	H I	Polyprenyltransferase (heme O synthase)
2036	5765	COG0111	H	Phosphoglycerate dehydrogenase or related dehydrogenase
1868	1915	COG0113	H	Delta-aminolevulinic acid dehydratase, porphobilinogen synthase
2079	4990	COG0115	E H	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase
1782	1835	COG0117	H	Riboflavin biosynthesis protein RibD, pyrimidine deaminase domain
1194	1297	COG0132	H	Dethiobiotin synthetase
2196	4701	COG0142	H	Geranylgeranyl pyrophosphate synthase
1952	3586	COG0147	E H	Anthranilate/para-aminobenzoate synthases component I
1676	3219	COG0156	H	7-keto-8-aminopelargonate synthetase or related enzyme
1716	1876	COG0157	H	Nicotinate-nucleotide pyrophosphorylase
1440	2987	COG0161	H	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase
1070	1164	COG0163	H	Flavin prenyltransferase UbiX
2153	2421	COG0171	H	NH3-dependent NAD+ synthetase
1566	3102	COG0175	E H	Phosphoadenylyl sulfate (PAPS) reductase/FAD synthetase or related enzyme
1881	1919	COG0181	H	Porphobilinogen deaminase
1589	3446	COG0189	J E H Q	Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily
2155	2367	COG0190	H	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase
2039	2238	COG0192	H	S-adenosylmethionine synthetase
2006	2084	COG0196	H	FAD synthase
1932	2076	COG0212	H	5-formyltetrahydrofolate cyclo-ligase
722	746	COG0214	H	Pyridoxal 5'-phosphate synthase subunit PdxS
2212	2273	COG0237	H	Dephospho-CoA kinase
1182	1350	COG0259	H	Pyridoxine/pyridoxamine 5'-phosphate oxidase
1714	3789	COG0262	H	Dihydrofolate reductase
1577	1682	COG0276	H	Protoheme ferro-lyase (ferrochelatase)
2079	2241	COG0285	H	Folylpolyglutamate synthase/Dihydropteroate synthase
1998	2471	COG0294	H	Dihydropteroate synthase
780	822	COG0301	J H	Adenylyl- and sulfurtransferase ThiI (thiamine and tRNA 4-thiouridine biosynthesis)
1514	1793	COG0302	H	GTP cyclohydrolase I
1701	3036	COG0303	H	Molybdopterin Mo-transferase (molybdopterin biosynthesis)
1866	1938	COG0307	H	Riboflavin synthase alpha chain
674	682	COG0311	H	Pyridoxal 5'-phosphate synthase subunit PdxT (glutamine amidotransferase)
1502	1541	COG0314	H	Molybdopterin synthase catalytic subunit MoaE
1666	1692	COG0315	H	Molybdenum cofactor biosynthesis enzyme MoaC
1711	1846	COG0320	H	Lipoate synthase
1469	1500	COG0321	H	Lipoate-protein ligase B
1942	2023	COG0325	H	Pyridoxal 5'-phosphate homeostasis protein YggS, UPF0001 family
1569	1710	COG0327	H	Putative GTP cyclohydrolase 1 type 2, NIF3 family
2119	2284	COG0340	H	Biotin-protein ligase
1706	2044	COG0351	H	Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase
1732	2632	COG0352	H	Thiamine monophosphate synthase
1206	1230	COG0368	H	Cobalamin synthase CobS (adenosylcobinamide-GDP ribazoletransferase)
1582	1663	COG0373	H	Glutamyl-tRNA reductase
1580	1617	COG0379	H	Quinolinate synthase
1719	2871	COG0382	H	4-hydroxybenzoate polyprenyltransferase
1018	1175	COG0391	G H	Archaeal 2-phospho-L-lactate transferase/Bacterial gluconeogenesis factor, CofD/UPF0052 family
1705	2640	COG0407	H	Uroporphyrinogen-III decarboxylase HemE
959	977	COG0408	H	Coproporphyrinogen-III oxidase HemH, oxygen-dependent
1723	1832	COG0413	H	Ketopantoate hydroxymethyltransferase
1622	1653	COG0414	H	Panthothenate synthetase
1360	1482	COG0422	H	4-amino-2-methyl-5-hydroxymethylpyrimidine (HMP) synthase ThiC
1436	2495	COG0425	J O H	Sulfur carrier protein TusA (tRNA thiolation, molybdenum cofactor biosynthesis)
1252	1646	COG0432	H	Thiamin phosphate synthase YjbQ, UPF0047 family
837	875	COG0447	H	1,4-Dihydroxy-2-naphthoyl-CoA synthase
2083	2328	COG0452	H	Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC
1832	2756	COG0476	H	Molybdopterin or thiamine biosynthesis adenylyltransferase
1600	1742	COG0499	H	S-adenosylhomocysteine hydrolase
1451	1721	COG0502	H	Biotin synthase or related enzyme
606	838	COG0510	H	Thiamine kinase or a related kinase
1937	2515	COG0512	E H	Anthranilate/para-aminobenzoate synthase component II (glutamine amidotransferase)
1631	1838	COG0521	H	Molybdopterin adenylyltransferase MoaB/MogA
1548	4743	COG0535	D H	Radical SAM superfamily maturase, SkfB/NifB/PqqE family
1343	2441	COG0543	C H	NAD(P)H-flavin reductase
1605	4596	COG0561	H R	Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases
2096	22530	COG0596	H R	2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold
1575	1883	COG0602	H	Organic radical activating enzyme NrdG/QueE
1578	1601	COG0611	H	Thiamine monophosphate kinase
1170	2545	COG0619	H	ECF-type transporter transmembrane protein EcfT
1979	3392	COG0635	H	Coproporphyrinogen-III oxidase HemN (oxygen-independent) or related Fe-S oxidoreductase
1361	6530	COG0654	C H	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
1608	2608	COG0661	T H	Predicted protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family
1757	8211	COG0667	H R	Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family
1986	2025	COG0669	H	Phosphopantetheine adenylyltransferase
1524	2053	COG0720	H	6-pyruvoyl-tetrahydropterin synthase
1555	1662	COG0746	H	Molybdopterin-guanine dinucleotide biosynthesis protein A
1367	1924	COG0775	F H	Nucleoside phosphorylase/nucleosidase, includes 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase MtnN and futalosine hydrolase MqnB
1836	2078	COG0801	H	7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase (folate biosynthesis)
1804	2505	COG0807	H	GTP cyclohydrolase II
584	762	COG0819	H	Aminopyrimidine aminohydrolase TenA (thiamine salvage pathway)
1150	1196	COG0853	H	Aspartate 1-decarboxylase
1200	1212	COG0854	H	Pyridoxine 5'-phosphate synthase PdxJ
851	902	COG1010	H	Precorrin-3B methylase
1903	5365	COG1011	H	FMN and 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase YigB, HAD superfamily (riboflavin biosynthesis)
149	167	COG1019	H	Phosphopantetheine adenylyltransferase
1573	3063	COG1052	C H R	Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase
465	539	COG1056	H	Nicotinamide mononucleotide adenylyltransferase
1958	2056	COG1057	H	Nicotinate-nucleotide adenylyltransferase NadD
989	1856	COG1060	H	2-iminoacetate synthase ThiH/Menaquinone biosynthesis enzymes MqnC and MqnE
641	830	COG1072	H	Pantothenate kinase
1754	4229	COG1120	H P	ABC-type cobalamin/Fe3+-siderophores transport system, ATPase component
1794	1913	COG1154	H I	Deoxyxylulose-5-phosphate synthase
778	792	COG1165	H	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
830	921	COG1169	H Q	Isochorismate synthase EntC
973	1352	COG1232	H	Protoporphyrinogen oxidase HemY/PPOX
683	1048	COG1239	H	Mg-chelatase subunit ChlI
1245	2356	COG1240	H	vWFA (von Willebrand factor type A) domain of Mg and Co chelatases
1025	1189	COG1268	H	Biotin transporter BioY
1168	1288	COG1270	H	Cobalamin biosynthesis protein CobD/CbiB
1776	4907	COG1335	H R	Nicotinamidase-related amidase
189	194	COG1339	H	Archaeal CTP-dependent riboflavin kinase
452	679	COG1348	H P	Nitrogenase ATPase subunit NifH/coenzyme F430 biosynthesis subunit CfbC
837	1351	COG1402	H	Creatinine amidohydrolase/Fe(II)-dependent FAPy formamide hydrolase (riboflavin and F420 biosynthesis)
60	61	COG1424	H	Pimeloyl-CoA synthetase
334	336	COG1427	H	Chorismate dehydratase (menaquinone biosynthesis, futalosine pathway)
657	992	COG1429	H	Cobalamin biosynthesis protein CobN, Mg-chelatase
126	126	COG1441	H	O-succinylbenzoate synthase
657	698	COG1469	H	GTP cyclohydrolase FolE2
1342	1972	COG1477	O H	FAD:protein FMN transferase ApbE
382	450	COG1478	H	F420-0:Gamma-glutamyl ligase (F420 biosynthesis)
1635	1785	COG1488	H	Nicotinic acid phosphoribosyltransferase
1122	1197	COG1492	H	Cobyric acid synthase
1524	1597	COG1521	H	Pantothenate kinase type III
1630	1794	COG1539	H	Dihydroneopterin aldolase
1191	2514	COG1541	H	Phenylacetate-coenzyme A ligase PaaK, adenylate-forming domain family
1958	2159	COG1546	H	Nicotinamide mononucleotide (NMN) deamidase PncC
144	145	COG1548	H	Methanofuran synthetase MfnF, hydantoinase/oxoprolinase family
665	671	COG1564	H	Thiamine pyrophosphokinase
1083	1258	COG1575	H	1,4-dihydroxy-2-naphthoate polyprenyltransferase
1910	2346	COG1587	H	Uroporphyrinogen-III synthase
1268	1347	COG1612	H	Heme A synthase
166	168	COG1634	H	6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase MptE (tetrahydrofolate and tetrahydromethanopterin biosynthesis)
180	188	COG1635	G H	Thiazole synthase/Archaeal ribulose 1,5-bisphosphate synthetase
583	663	COG1641	H	CTP-dependent cyclometallase, nickel-pincer nucleotide (NPN) cofactor biosynthesis
1317	1459	COG1648	H	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain)
157	159	COG1701	H	Archaeal phosphopantothenate synthetase
74	74	COG1731	H	Archaeal riboflavin synthase
832	893	COG1763	H	Molybdopterin-guanine dinucleotide biosynthesis protein
467	536	COG1767	H	Triphosphoribosyl-dephospho-CoA synthetase
1017	1175	COG1797	H	Cobyrinic acid a,c-diamide synthase
191	206	COG1809	H	Phosphosulfolactate synthase, CoM biosynthesis protein A
205	215	COG1812	H	Archaeal S-adenosylmethionine synthetase
125	128	COG1821	H	Tyramine-glutamate ligase MfnD (methanofuran biosynthesis), ATP-grasp superfamily
255	284	COG1827	K H	Transcriptional regulator of NAD metabolism, contains HTH and 3H domains
168	175	COG1829	H	Archaeal pantoate kinase
1249	2657	COG1840	G H	ABC-type transport systems for B6 and hexose phosphate, periplasmic component
315	348	COG1865	H	Adenosylcobinamide amidohydrolase
151	151	COG1891	H	4-(hydroxymethyl)-2-furancarboxaldehyde phosphate synthase MfnB
1226	1922	COG1893	H	Ketopantoate reductase
642	649	COG1903	H	Cobalt-precorrin-5B methyltransferase
233	255	COG1907	H	Beta-ribofuranosylaminobenzene 5'-phosphate synthase (methanopterin biosynthesis)
178	178	COG1909	H	Archaeal dephospho-CoA kinase
669	722	COG1912	V H	Stereoselective (R,S)-S-adenosylmethionine hydrolase (adenosine-forming)
306	316	COG1920	H	2-phospho-L-lactate guanylyltransferase, coenzyme F420 biosynthesis enzyme, CobY/MobA/RfbA family
1487	1548	COG1932	E H	Phosphoserine aminotransferase
329	430	COG1953	F H	Cytosine/uracil/thiamine/allantoin permease
67	89	COG1962	H	Tetrahydromethanopterin S-methyltransferase, subunit H
277	309	COG1964	H I	Archaeal tetraether lipid synthase/C-terminal domain of the GTP 3',8'-cyclase MoaA, radical SAM superfamily
1537	2208	COG1977	H	Molybdopterin synthase sulfur carrier subunit MoaD
846	918	COG1981	H	Protoporphyrinogen oxidase HemJ (unrelated to HemG or HemY)
1973	2531	COG1985	H	Pyrimidine reductase, riboflavin biosynthesis
1368	1631	COG1995	H	4-hydroxy-L-threonine phosphate dehydrogenase PdxA
1258	1286	COG2022	H	Thiazole synthase ThiGH, ThiG subunit (thiamin biosynthesis)
1189	1294	COG2038	H	NaMN:DMB phosphoribosyltransferase
463	497	COG2045	H	Phosphosulfolactate phosphohydrolase or related enzyme
147	147	COG2054	H	5-(aminomethyl)-3-furanmethanol-phosphate kinase MfnE (methanofuran biosynthesis)
1057	1174	COG2068	H	CTP:molybdopterin cytidylyltransferase MocA
661	724	COG2073	H	Cobalt-precorrin 5A hydrolase
854	952	COG2082	H	Precorrin-8X methylmutase CbiC/CobH
1046	1139	COG2087	H	Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase
961	1196	COG2091	H	Phosphopantetheinyl transferase
1305	1411	COG2096	H	Cob(II)alamin adenosyltransferase
122	123	COG2098	H	7,8-dihydroneopterin aldolase MptD (tetrahydrofolate and tetrahydromethanopterin biosynthesis)
664	687	COG2099	H	Precorrin-6x reductase
1394	1531	COG2104	J H	Sulfur carrier protein ThiS/TtuB (thiamine biosynthesis, tRNA 2-thiouridylation)
313	321	COG2107	H	1,4-dihydroxy-6-naphtoate synthase (menaquinone biosynthesis, futalosine pathway)
1119	1341	COG2109	H	ATP:corrinoid adenosyltransferase
861	1136	COG2138	H	Sirohydrochlorin ferrochelatase
1245	8519	COG2141	H R	Flavin-dependent oxidoreductase, luciferase family (includes alkanesulfonate monooxygenase SsuD and methylene tetrahydromethanopterin reductase)
680	708	COG2145	H	Hydroxyethylthiazole kinase, sugar kinase family
1226	1400	COG2154	H	Pterin-4a-carbinolamine dehydratase
2207	18977	COG2226	J H	Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG or 23S rRNA G745 methylase RmlAII or tRNA-U5 methylase TRM9
1942	8109	COG2227	H	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase
711	798	COG2236	H	Hypoxanthine phosphoribosyltransferase
542	596	COG2240	H	Pyridoxal/pyridoxine/pyridoxamine kinase
877	915	COG2241	H	Precorrin-6B methylase 1
974	1243	COG2242	H	Precorrin-6B methylase 2
848	1048	COG2243	H	Precorrin-2 methylase
194	200	COG2266	H	GTP:adenosylcobinamide-phosphate guanylyltransferase
985	1547	COG2329	H	Heme-degrading monooxygenase HmoA and related ABM domain proteins
520	592	COG2510	H	Riboflavin transporter RibN, EamA domain
371	1657	COG2710	H P	Nitrogenase Mo-Fe protein NifD/coenzyme F430 biosynthesis subunit CfbD
858	897	COG2875	H	Precorrin-4 methylase
1689	1925	COG2896	H	GTP 3',8-cyclase (molybdenum cofactor biosynthesis protein MoaA)
421	439	COG2918	H	Gamma-glutamylcysteine synthetase
384	410	COG2941	H	Demethoxyubiquinone hydroxylase, CLK1/Coq7/Cat5 family (ubiquinone biosynthesis)
678	680	COG2960	H	Ubiquinone biosynthesis accessory factor UbiK
324	446	COG2978	H	p-Aminobenzoyl-glutamate transporter AbgT
299	302	COG3154	H	Ubiquinone biosynthesis accessory factor UbiT, lipid carrier SCP2 domain
522	530	COG3161	H	4-hydroxybenzoate synthetase (chorismate-pyruvate lyase)
452	457	COG3165	H	Ubiquinone biosynthesis protein UbiJ, contains SCP2 domain
397	431	COG3172	H	Nicotinamide riboside kinase
640	735	COG3201	H	Nicotinamide riboside transporter PnuC
289	354	COG3236	V H	N-glycosidase YbiA/RibX (riboflavin biosynthesis, damage control), NADAR superfamily
210	215	COG3252	H	Methenyltetrahydromethanopterin cyclohydrolase
504	514	COG3253	H P	Coproheme decarboxylase/chlorite dismutase
97	98	COG3445	H	Autonomous glycyl radical cofactor GrcA
468	492	COG3572	H	Gamma-glutamylcysteine synthetase
666	890	COG3585	H	Molybdopterin-binding protein MopI
338	357	COG3601	H	Riboflavin transporter FmnP
159	171	COG3697	H I	Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase)
233	234	COG3840	H	ABC-type thiamine transport system, ATPase component ThiQ
246	255	COG3859	H	Thiamine transporter ThiT
245	280	COG3961	G H R	TPP-dependent 2-oxoacid decarboxylase, includes indolepyruvate decarboxylase
14	14	COG4016	H	Iron-guanylylpyridinol (FeGP) cofactor biosynthesis protein HcgF, CinA family
13	13	COG4017	H	Iron-guanylylpyridinol (FeGP) cofactor biosynthesis protein, methyltransferase HcgC
14	14	COG4018	H	Iron-guanylylpyridinol (FeGP) cofactor biosynthesis protein, fibrillarin family
13	13	COG4019	H	Iron-guanylylpyridinol (FeGP) cofactor biosynthesis protein HcgB, guanylyltransferase
173	199	COG4032	H	Sulfopyruvate decarboxylase, TPP-binding subunit (coenzyme M biosynthesis)
45	56	COG4054	H	Methyl coenzyme M reductase, beta subunit
44	55	COG4055	H	Methyl coenzyme M reductase, subunit D
45	46	COG4056	H	Methyl coenzyme M reductase, subunit C
45	57	COG4057	H	Methyl coenzyme M reductase, gamma subunit
45	59	COG4058	H	Methyl coenzyme M reductase, alpha subunit
36	36	COG4059	H	Tetrahydromethanopterin S-methyltransferase, subunit E
35	35	COG4060	H	Tetrahydromethanopterin S-methyltransferase, subunit D
36	36	COG4061	H	Tetrahydromethanopterin S-methyltransferase, subunit C
36	36	COG4062	H	Tetrahydromethanopterin S-methyltransferase, subunit B
63	89	COG4063	H	Tetrahydromethanopterin S-methyltransferase, subunit A
25	25	COG4064	H	Tetrahydromethanopterin S-methyltransferase, subunit G
543	716	COG4111	H	ATP-responsive regulator of NAD biosynthesis
74	76	COG4138	H	ABC-type cobalamin transport system, ATPase component BtuD
98	101	COG4139	H	ABC-type cobalamin transport system, permease component BtuC
459	476	COG4143	H	ABC-type thiamine transport system, periplasmic component TbpA
259	281	COG4145	H	Na+/panthothenate symporter
979	3721	COG4206	H	Outer membrane cobalamin receptor protein BtuB
29	29	COG4218	H	Tetrahydromethanopterin S-methyltransferase, subunit F
337	365	COG4256	K H	RNA-binding regulator of hemin uptake HemP/HmuP
400	433	COG4547	H	Cobalamin biosynthesis cobaltochelatase CobT subunit
472	564	COG4635	H	Protoporphyrinogen IX oxidase, menaquinone-dependent (flavodoxin domain)
294	389	COG4720	H	ECF-type riboflavin transporter, membrane (S) component
221	236	COG4721	H	ABC-type thiamine/hydroxymethylpyrimidine transport system, permease component
151	151	COG4732	H	ECF-type thiazole transporter, membrane (S) component ThiW
225	282	COG4822	H	Cobalamin biosynthesis protein CbiK, Co2+ chelatase
114	198	COG5031	H	Ubiquinone biosynthesis protein Coq4
50	50	COG5146	H	Pantothenate kinase
201	253	COG5398	H	Heme oxygenase
376	471	COG5424	H	Pyrroloquinoline quinone (PQQ) biosynthesis protein C
198	208	COG5590	H	Ubiquinone biosynthesis protein COQ9
175	678	COG5598	H	Trimethylamine:corrinoid methyltransferase
193	276	COG5746	H	Light-independent protochlorophyllide reductase subunit B, BchB (=ChlB)
155	155	COG5747	H	Light-independent protochlorophyllide reductase subunit N, BchN (=ChlN)
581	1094	COG5748	H	Light-dependent NADPH-protochlorophyllide oxidoreductase
579	1406	COG5749	H	Chlorophyllide a oxygenase/letal leaf spot protein
82	82	COG5753	H	Bacteriochlorophyllide reductase subunit BchX
81	81	COG5754	H	Bacteriochlorophyllide reductase subunit BchY
82	82	COG5755	H	Bacteriochlorophyllide reductase subunit BchZ
131	184	COG5759	H	Mg-protoporphyrin IX monomethyl ester cyclase BchE, aerobic (=Ycf59)