O - Posttranslational modification, protein turnover, chaperones

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COG definitions	Organims	Proteins	Median Protein Length	Genes
211	1,309	175,601	280.0	186

Organism	Protein	COG	Cat	Annotation
421	445	COG0068	O	Hydrogenase maturation factor HypF (carbamoyltransferase)
1049	2461	COG0071	O	Small heat shock protein IbpA, HSP20 family
177	209	COG0170	M O	Dolichol kinase
1093	1586	COG0225	O	Peptide methionine sulfoxide reductase MsrA
1041	1359	COG0229	O	Peptide methionine sulfoxide reductase MsrB
1184	1437	COG0234	O	Co-chaperonin GroES (HSP10)
1215	3940	COG0265	O	Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain
568	607	COG0278	O	Glutaredoxin-related protein
427	528	COG0298	O	Hydrogenase maturation factor HybG, HypC/HupF family
503	604	COG0309	O	Carbamoyl dehydratase HypE (hydrogenase maturation factor)
964	2023	COG0316	O	Fe-S cluster assembly iron-binding protein IscA
789	936	COG0326	O	Molecular chaperone, HSP90 family
1163	3060	COG0330	O	Regulator of protease activity HflC, stomatin/prohibitin superfamily
670	869	COG0339	O	Zn-dependent oligopeptidase, M3 family
690	697	COG0354	O	Folate-binding protein YgfZ, synthesis and repair of Fe-S clusters
444	506	COG0375	O	Hydrogenase maturation factor HypA/HybF, metallochaperone involved in Ni insertion
687	947	COG0378	O	Hydrogenase/urease maturation factor HypB, Ni2+-binding GTPase
1000	1038	COG0396	O	Fe-S cluster assembly ATPase SufC
531	560	COG0397	O	Protein adenylyltransferase (AMPylase) SelO/YdiU (selenoprotein O)
424	439	COG0409	O	Hydrogenase maturation factor HypD
832	1439	COG0425	J O H	Sulfur carrier protein TusA (tRNA thiolation, molybdenum cofactor biosynthesis)
1263	2652	COG0443	O	Molecular chaperone DnaK (HSP70)
1295	1892	COG0459	O	Chaperonin GroEL (HSP60 family)
1172	1777	COG0465	O	ATP-dependent Zn proteases
943	1278	COG0466	O	ATP-dependent Lon protease, bacterial type
1260	3406	COG0484	O	DnaJ-class molecular chaperone with C-terminal Zn finger domain
1280	3109	COG0492	O	Thioredoxin reductase
1008	2119	COG0501	O	Zn-dependent protease with chaperone function
1005	2959	COG0526	O	Thiol-disulfide isomerase or thioredoxin
1172	3035	COG0542	O	ATP-dependent Clp protease, ATP-binding subunit ClpA
1158	1209	COG0544	O	FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor)
707	1561	COG0545	O	FKBP-type peptidyl-prolyl cis-trans isomerase
1260	1389	COG0576	O	Molecular chaperone GrpE (heat shock protein HSP-70)
1011	1191	COG0606	O	Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family
965	1572	COG0616	O	Periplasmic serine protease, ClpP class
570	4926	COG0625	O	Glutathione S-transferase
218	538	COG0638	O	20S proteasome, alpha and beta subunits
399	736	COG0641	O	Sulfatase maturation enzyme AslB, radical SAM superfamily
1107	2246	COG0652	O	Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family
353	426	COG0678	O	Peroxiredoxin
1181	1189	COG0691	O	tmRNA-binding protein
769	1019	COG0694	O	Fe-S cluster biogenesis protein NfuA, 4Fe-4S-binding domain
971	1875	COG0695	O	Glutaredoxin
972	1833	COG0705	O	Membrane-associated serine protease, rhomboid family
1003	1941	COG0719	O	Fe-S cluster assembly scaffold protein SufB
1160	2108	COG0740	O	ATP-dependent protease ClpP, protease subunit
1235	1418	COG0750	K O	Membrane-associated protease RseP, regulator of RpoE activity
928	1112	COG0755	O	ABC-type transport system involved in cytochrome c biogenesis, permease component
943	2381	COG0760	O	Peptidyl-prolyl isomerase, parvulin family
677	712	COG0762	O	Cytochrome b6 maturation protein CCB3/Ycf19 and related maturases, YggT family
592	882	COG0785	O C	Cytochrome c biogenesis protein CcdA
1044	2673	COG0793	O	C-terminal processing protease CtpA/Prc, contains a PDZ domain
1024	1274	COG0822	O	Fe-S cluster assembly scaffold protein IscU, NifU family
406	435	COG0829	O	Urease accessory protein UreH
408	436	COG0830	O	Urease accessory protein UreF
848	1109	COG0846	O	NAD-dependent protein deacetylase, SIR2 family
123	143	COG1025	O	Secreted/periplasmic Zn-dependent peptidases, insulinase-like
140	147	COG1026	O	Zn-dependent peptidase, M16 (insulinase) family
392	477	COG1030	O	Membrane-bound serine protease NfeD, ClpP class
690	1131	COG1047	O	Peptidyl-prolyl cis-trans isomerase, FKBP type
418	536	COG1067	O	Predicted ATP-dependent protease
435	571	COG1076	O	DnaJ domain-containing protein
875	1586	COG1086	M O	NDP-sugar epimerase, includes UDP-GlcNAc-inverting 4,6-dehydratase FlaA1 and capsular polysaccharide biosynthesis protein EpsC
886	2984	COG1123	O	ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain
507	584	COG1138	O C	Cytochrome c biogenesis protein CcmF
651	1367	COG1180	O	Pyruvate-formate lyase-activating enzyme
1137	1268	COG1219	O	ATP-dependent protease Clp, ATPase subunit ClpX
700	702	COG1220	O	ATP-dependent protease HslVU (ClpYQ), ATPase subunit HslU
320	457	COG1222	O	ATP-dependent 26S proteasome regulatory subunit
1131	4137	COG1225	O	Peroxiredoxin
678	2312	COG1262	O	Formylglycine-generating enzyme, required for sulfatase activity, contains SUMF1/FGE domain
604	1082	COG1266	O	Membrane protease YdiL, CAAX protease family
529	939	COG1277	O	ABC-type transport system involved in multi-copper enzyme maturation, permease component
690	699	COG1281	O	Redox-regulated molecular chaperone, HSP33 family
158	216	COG1287	O	Asparagine N-glycosylation enzyme, membrane subunit Stt3
469	482	COG1293	J O	Ribosome quality control (RQC) protein RqcH, Rqc2/NEMF/Tae2 family, contains fibronectin-(FbpA) and RNA- (NFACT) binding domains
898	2389	COG1305	O	Transglutaminase-like enzyme, putative cysteine protease
385	494	COG1310	O	Proteasome lid subunit RPN8/RPN11, contains Jab1/MPN domain metalloenzyme (JAMM) motif
383	423	COG1333	O C	Cytochrome c biogenesis protein ResB
132	133	COG1382	O	Prefoldin, chaperonin cofactor
608	616	COG1391	O	Glutamine synthetase adenylyltransferase
524	857	COG1397	O	ADP-ribosylglycohydrolase
806	2868	COG1404	O	Serine protease, subtilisin family
355	736	COG1433	O	Predicted Fe-Mo cluster-binding protein, NifX family
759	1102	COG1477	O H	FAD:protein FMN transferase ApbE
518	600	COG1495	O	Disulfide bond formation protein DsbB
100	152	COG1572	O	Serine protease, subtilase family
602	617	COG1585	O	Membrane protein implicated in regulation of membrane protease activity
870	2028	COG1651	O	Protein thiol-disulfide isomerase DsbC
1083	6267	COG1670	J O	Protein N-acetyltransferase, RimJ/RimL family
551	809	COG1703	O	GTPase of the G3E family (not a periplasmic protein kinase)
123	126	COG1730	O	Prefoldin subunit 5
471	1110	COG1858	O	Cytochrome c peroxidase
284	339	COG1899	J O	Deoxyhypusine synthase
199	215	COG1928	O	Dolichyl-phosphate-mannose--protein O-mannosyl transferase
39	39	COG1973	O	Hydrogenase maturation factor HypE
629	1031	COG1975	O	Molybdoenzyme maturation factor PaoD (Mo cofactor insertion), XdhC/CoxF family
754	1044	COG1994	O	Zn-dependent protease (includes sporulation protein SpoIVFB)
634	1263	COG1999	O	Cytochrome oxidase Cu insertion factor, SCO1/SenC/PrrC family
590	954	COG2020	O	Protein-S-isoprenylcysteine O-methyltransferase Ste14
296	315	COG2039	O	Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase)
462	484	COG2077	O	Peroxiredoxin
770	843	COG2127	O	ATP-dependent Clp protease adapter protein ClpS
898	908	COG2137	O	SOS response regulatory protein OraA/RecX, interacts with RecA
194	279	COG2143	O	Thioredoxin-related protein SoxW
829	1313	COG2151	O	Metal-sulfur cluster biosynthetic enzyme
577	642	COG2166	O	Sulfur transfer protein SufE, Fe-S cluster assembly
419	597	COG2170	O	Gamma-glutamyl:cysteine ligase YbdK, ATP-grasp superfamily
236	271	COG2180	O C P	Nitrate reductase assembly protein NarJ, required for insertion of molybdenum cofactor
541	1635	COG2234	O E	Zn-dependent amino- or carboxypeptidase, M28 family
362	389	COG2317	O	Zn-dependent carboxypeptidase, M32 family
211	248	COG2322	O	Cytochrome oxidase assembly protein CtaM/YozB, DUF420 family
498	508	COG2332	O C	Cytochrome c biogenesis protein CcmE
523	798	COG2355	O E	Zn-dependent dipeptidase, microsomal dipeptidase homolog
642	653	COG2360	O	Leu/Phe-tRNA-protein transferase
195	241	COG2370	O	Hydrogenase/urease accessory protein HupE
342	360	COG2371	O	Urease accessory protein UreE
495	500	COG2386	O	ABC-type transport system involved in cytochrome c biogenesis, permease component
809	1355	COG2518	O	Protein-L-isoaspartate O-methyltransferase
330	335	COG2738	O	Zn-dependent membrane protease YugP
643	913	COG2761	O	Predicted dithiol-disulfide isomerase, DsbA/YjbH family (virulence, stress resistance)
627	824	COG2825	M O	Periplasmic chaperone for outer membrane proteins, Skp family
579	597	COG2844	T O	UTP:GlnB (protein PII) uridylyltransferase
250	284	COG2846	O	Iron-sulfur cluster repair protein YtfE, RIC family, contains ScdAN and hemerythrin domains
511	810	COG2856	O	Zn-dependent peptidase ImmA, M78 family
353	355	COG2924	O P	Fe-S cluster biosynthesis and repair protein YggX
384	390	COG2935	O	Arginyl-tRNA--protein-N-Asp/Glu arginylyltransferase
438	434	COG2938	O	Succinate dehydrogenase flavin-adding protein, antitoxin component of the CptAB toxin-antitoxin module
314	314	COG2969	O	Stringent starvation protein B, binds SsrA peptide
200	199	COG2975	O	Fe-S-cluster formation regulator IscX/YfhJ
128	134	COG2991	O C	Na+-NQR maturation protein NqrM
50	64	COG2994	O	ACP:hemolysin acyltransferase (hemolysin-activating protein)
79	88	COG2999	O	Glutaredoxin 2
189	204	COG3058	O C	Formate dehydrogenase maturation protein FdhE
151	156	COG3062	O	Cytoplasmic chaperone NapD for the signal peptide of periplasmic nitrate reductase NapAB
416	473	COG3088	O C	Cytochrome c-type biogenesis protein CcmH/NrfF
1255	3504	COG3118	O	Chaperedoxin CnoX, contains thioredoxin-like and TPR-like domains, YbbN/TrxSC family
278	279	COG3175	O C	Cytochrome c oxidase assembly protein Cox11
402	530	COG3187	O	Heat shock protein HslJ
388	404	COG3197	O	Cytochrome oxidase maturation protein, CcoS/FixS family
289	388	COG3212	O	PepSY domain containing protein, regulator of zincin peptidase activity
217	435	COG3227	O	Zn-dependent metalloprotease (Neutral protease B)
287	428	COG3336	O C	Cytochrome c oxidase assembly protein CtaG
424	571	COG3346	O	Cytochrome oxidase assembly protein ShyY1
280	555	COG3381	O	Cytoplasmic chaperone TorD involved in molybdoenzyme TorA maturation
61	61	COG3389	O	Presenilin-like membrane protease, A22 family
238	247	COG3484	O	Predicted proteasome-type protease
132	154	COG3531	O	Predicted protein-disulfide isomerase, contains CxxC motif
158	213	COG3555	O	Aspartyl/asparaginyl beta-hydroxylase, cupin superfamily
336	478	COG3590	O	Predicted metalloendopeptidase
298	543	COG3591	O	V8-like Glu-specific endopeptidase
135	248	COG3640	O	CO dehydrogenase nickel-insertion accessory protein CooC1
185	278	COG3672	O	Predicted transglutaminase-like protein
225	308	COG3678	O	Periplasmic chaperone Spy, Spy/CpxP family
234	291	COG3751	J O	Proline 4-hydroxylase (includes Rps23 Pro-64 3,4-dihydroxylase Tpa1), contains SM-20 domain
187	185	COG3785	O	Heat shock protein HspQ
153	154	COG3814	O	SspB-like protein, predicted to bind SsrA peptide
205	217	COG3823	O	Glutamine cyclotransferase
270	306	COG3824	O	Predicted Zn-dependent protease, minimal metalloprotease (MMP)-like domain
172	173	COG3869	O	Protein-arginine kinase McsB
180	187	COG3880	O	Protein-arginine kinase activator protein McsA
189	225	COG3897	O	Protein N-terminal and lysine N-methylase, NNT1/EFM7 family
212	428	COG3914	O	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family
478	507	COG4133	O	ABC-type transport system involved in cytochrome c biogenesis, ATPase component
658	1006	COG4232	O	Thiol:disulfide interchange protein DsbD
249	275	COG4233	O C	Thiol-disulfide interchange protein, contains DsbC and DsbD domains
595	915	COG4235	O C	Cytochrome c-type biogenesis protein CcmH/NrfG
257	277	COG4260	O	Membrane protease subunit, stomatin/prohibitin family, contains C-terminal Zn-ribbon domain
35	36	COG4346	O	Predicted membrane-bound dolichyl-phosphate-mannose-protein mannosyltransferase
132	187	COG4412	O	Bacillopeptidase F, M6 metalloprotease family
37	39	COG4545	O	Glutaredoxin-related protein
64	63	COG4574	O	Serine protease inhibitor ecotin
905	3378	COG4783	M O	Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains
174	236	COG4826	O	Serine protease inhibitor
44	44	COG4837	O	Disulfide oxidoreductase YuzD
48	55	COG4846	O C	Cytochrome c biogenesis protein CcdC
163	263	COG4870	O	Cysteine protease, C1A family
66	73	COG4875	O	Protein kinase association domain CaMKII_AD, NTF2-like superfamily
102	110	COG4930	O	Predicted ATP-dependent Lon-type protease
92	260	COG4934	O	Serine protease, subtilase family
152	298	COG4935	O	Regulatory P domain of the subtilisin-like proprotein convertases and other proteases
287	410	COG4959	U O	Type IV secretory pathway, protease TraF
188	220	COG4960	T O	Flp pilus assembly protein, peptidase CpaA
418	437	COG4987	O C	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components
455	508	COG4988	O C	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components
16	18	COG5029	O I	Prenyltransferase, beta subunit
19	22	COG5078	O	Ubiquitin-protein ligase
12	12	COG5131	O	Ubiquitin-like protein
4	4	COG5160	O	Protease, Ulp1 family
4	5	COG5206	O	Glycosylphosphatidylinositol transamidase (GPIT), subunit GPI8
290	302	COG5265	O	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components
9	13	COG5272	O	Ubiquitin
181	276	COG5282	O	Zn-dependent metallopeptidase, zincin/DUF2342 superfamily
47	67	COG5380	O	Lipase chaperone LimK
140	140	COG5387	O	Mitochondrial FoF1-type ATP synthase assembly chaperone ATP12
704	723	COG5405	O	ATP-dependent protease HslVU (ClpYQ), peptidase subunit
19	19	COG5494	O	Predicted thioredoxin/glutaredoxin
86	106	COG5513	O	Chagasin-like inhibitor of cysteine peptidase, I42 family
7	12	COG5533	O	Ubiquitin C-terminal hydrolase
65	72	COG5549	O	Predicted Zn-dependent protease
41	90	COG5550	O	Predicted aspartyl protease
23	23	COG5580	O	Activator of HSP90 ATPase
128	363	COG5640	O	Secreted trypsin-like serine protease
179	224	COG5646	O P	Iron-binding protein Fra/YdhG, frataxin family (Fe-S cluster biosynthesis)
47	47	COG5661	O	Predicted secreted Zn-dependent protease
15	16	COG5664	O	Predicted secreted Zn-dependent protease
40	40	COG5774	O C	Cytochrome b6 maturation protein CCB1
40	40	COG5781	O C	Cytochrome b6 maturation protein CCB2
107	107	COG5818	K D O	Stage II sporulation protein SpoIIGA (protease, processing of pro-sigma-E to active sigma-E)
108	114	COG5832	D O	Stage IV sporulation protein SpoIVB, serine protease, degrades SpoIIQ, SpoIVFA
68	73	COG5866	D O	Sporulation-specific protease YabG