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R - General function prediction only

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COG
definitions
Organims Proteins Median Protein
Length
Genes
559 2,289 515,180 309.0 281
Organism Protein COG Cat Annotation
1669 4258 COG0110 R Acetyltransferase, isoleucine patch superfamily
674 821 COG0121 R Predicted glutamine amidotransferase YafJ
1884 9239 COG0300 R Short-chain dehydrogenase
1131 1547 COG0384 R Predicted epimerase YddE/YHI9, PhzF superfamily
1073 1560 COG0385 R Predicted Na+-dependent transporter YfeH
1204 1714 COG0400 R Predicted esterase
1624 4467 COG0402 F R Cytosine/adenosine deaminase or related metal-dependent hydrolase
635 679 COG0429 R Predicted hydrolase of the alpha/beta-hydrolase fold
115 124 COG0454 K R N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2)
1537 8665 COG0457 R Tetratricopeptide (TPR) repeat
846 2343 COG0477 G E P R MFS family permease, includes anhydromuropeptide permease AmpG
1969 7381 COG0488 R ATPase components of ABC transporters with duplicated ATPase domains
2130 11220 COG0491 R Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II
1785 4090 COG0493 E R NADPH-dependent glutamate synthase beta chain or related oxidoreductase
166 179 COG0500 Q R SAM-dependent methyltransferase
1207 2680 COG0523 R Zinc metallochaperone YeiR/ZagA and related GTPases, G3E family
2239 4083 COG0537 F R Purine nucleoside phosphoramidase/Ap4A hydrolase, histidine triade (HIT) family
1605 4596 COG0561 H R Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases
2096 22530 COG0596 H R 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold
1360 2555 COG0599 R Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone decarboxylase family
1655 8394 COG0604 C R NADPH:quinone reductase or related Zn-dependent oxidoreductase
1842 4923 COG0612 R Predicted Zn-dependent peptidase, M16 family
1395 2500 COG0622 R Predicted phosphodiesterase, calcineurin family
2121 5839 COG0628 R Predicted PurR-regulated permease PerM
728 916 COG0645 R Predicted kinase, contains AAA domain
1621 2419 COG0663 R Carbonic anhydrase or acetyltransferase, isoleucine patch superfamily
1757 8211 COG0667 H R Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family
1864 13722 COG0673 R Predicted dehydrogenase
1466 2716 COG0679 R Predicted permease, AEC (auxin efflux carrier) family
2068 13867 COG0697 G E R Permease of the drug/metabolite transporter (DMT) superfamily
1453 4449 COG0702 R Uncharacterized conserved protein YbjT, contains NAD(P)-binding and DUF2867 domains
1941 7177 COG0714 R MoxR-like ATPase, includes components of a predicted archaeal secretion system
862 1301 COG0727 R Uncharacterized protein YkgJ, contains CxxCxxCC motif
881 1542 COG0733 R Na+-dependent transporter, SNF family
1008 3397 COG0790 R TPR repeat
664 726 COG0857 R BioD-like N-terminal domain of phosphotransacetylase
157 158 COG1031 R Radical SAM superfamily enzyme with C-terminal helix-hairpin-helix motif
1388 4492 COG1032 R Radical SAM superfamily enzyme YgiQ, UPF0313 family
891 1732 COG1033 R Predicted exporter protein, RND superfamily
1983 2123 COG1040 R DNA utilization protein ComFC/GntX, contains phosphoribosyltransferase domain
1573 3063 COG1052 C H R Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase
1667 5740 COG1063 E R Threonine dehydrogenase or related Zn-dependent dehydrogenase
734 891 COG1078 R HD superfamily phosphohydrolase
164 165 COG1084 R GTP-binding protein, GTP1/Obg family
1030 1244 COG1090 R NAD dependent epimerase/dehydratase family enzyme
333 463 COG1098 R Predicted RNA-binding protein, contains ribosomal protein S1 (RPS1) domain
227 242 COG1099 R Predicted metal-dependent hydrolase, TIM-barrel fold
281 805 COG1100 R GTPase SAR1 family domain
459 547 COG1101 R ABC-type uncharacterized transport system, ATPase component
386 542 COG1106 R ATPase/GTPase, AAA15 family
1206 3024 COG1122 P R Energy-coupling factor transporter ATP-binding protein EcfA2
655 1583 COG1149 R MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain
853 1083 COG1168 E R Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities
2035 3482 COG1181 M R D-alanine-D-alanine ligase or related ATP-grasp enzyme
414 542 COG1237 R Metal-dependent hydrolase, beta-lactamase superfamily II
547 584 COG1242 R Radical SAM superfamily enzyme
88 88 COG1255 R Predicted small methyltransferase MTH1000, UPF0146 family
821 878 COG1259 R Bifunctional DNase/RNase
389 570 COG1288 R Predicted membrane transporter YfcC, affects glyoxylate shunt
418 518 COG1297 R Predicted oligopeptide transporter, OPT family
1328 2098 COG1304 C I R FMN-dependent dehydrogenase, includes L-lactate dehydrogenase and type II isopentenyl diphosphate isomerase
189 203 COG1306 R Predicted glycosyl hydrolase, alpha amylase family
319 348 COG1313 R Radical SAM superfamily enzyme PflX
109 111 COG1326 R Uncharacterized archaeal Zn-finger protein
1052 1514 COG1331 R Uncharacterized conserved protein YyaL, SSP411 family, contains thoiredoxin and six-hairpin glycosidase-like domains
521 544 COG1334 R Uncharacterized conserved protein, FlaG/YvyC family
1776 4907 COG1335 H R Nicotinamidase-related amidase
337 432 COG1342 R Predicted DNA-binding protein, UPF0251 family
500 562 COG1355 R Predicted class III extradiol dioxygenase, MEMO1 family
217 386 COG1361 R S-layer protein MJ0795, predicted component of type IV pili-like system
17 19 COG1365 R Predicted ATPase, PP-loop superfamily
652 1900 COG1373 R Predicted ATPase, AAA+ superfamily
304 337 COG1379 R PHP family phosphoesterase with a Zn ribbon
663 775 COG1380 R Putative effector of murein hydrolase LrgA, UPF0299 family
1098 1897 COG1387 E R Histidinol phosphatase or related hydrolase of the PHP family
595 692 COG1407 R Metallophosphoesterase superfamily enzyme
1193 1830 COG1408 R Phosphohydrolase/phosphodiesterase, MPP superfamily
133 134 COG1411 R Uncharacterized conserved protein related to proFAR isomerase (HisA)
817 3011 COG1413 R HEAT repeat
1291 2209 COG1418 J R HD superfamily phosphodieaserase, includes HD domain of RNase Y
1216 1755 COG1432 R NYN domain, predicted PIN-related RNAse, tRNA/rRNA maturation
405 454 COG1437 T R Adenylate cyclase class IV, CYTH domain (includes archaeal enzymes of unknown function)
1393 1775 COG1451 R UTP pyrophosphatase, metal-dependent hydrolase family
433 895 COG1453 R Predicted oxidoreductase of the aldo/keto reductase family
97 97 COG1458 R Predicted RNase MK1237, contains PIN domain, UPF0278 family
1574 4269 COG1473 R Metal-dependent amidase/aminoacylase/carboxypeptidase
203 246 COG1483 R Predicted ATPase, AAA+ superfamily
207 208 COG1491 R Predicted nucleic acid-binding OB-fold protein
66 79 COG1532 R Predicted RNA-binding protein
506 1367 COG1545 R Uncharacterized OB-fold protein, contains Zn-ribbon domain
319 354 COG1563 R Uncharacterized MnhB-related membrane protein, DUF4040 domain
799 813 COG1565 R SAM-dependent methyltransferase, MidA family
387 630 COG1569 R Predicted nucleic acid-binding protein, contains PIN domain
426 794 COG1572 R Uncharacterized protein, contains DUF3344 and CARDB domains
1104 2085 COG1574 R Predicted amidohydrolase YtcJ
836 890 COG1579 R Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain
1444 2616 COG1597 I R Phosphatidylglycerol kinase, diacylglycerol kinase family
617 656 COG1606 R ATP-utilizing enzyme, PP-loop superfamily
1473 1482 COG1610 R Uncharacterized conserved protein YqeY, may have tRNA amino acid amidase activity
15 15 COG1627 R Uncharacterized conserved protein MJ0835, predicted component of type IV pili-like system, DUF1515 family
195 197 COG1628 R Endonuclease V homolog, UPF0215 family
169 171 COG1645 R Uncharacterized Zn-finger containing protein, UPF0148 family
336 341 COG1656 R Uncharacterized conserved protein, contains PIN-related Mut7-C RNAse domain
433 495 COG1661 R Predicted DNA-binding protein with PD1-like DNA-binding motif, PPC/DUF296 domain
88 107 COG1665 R Predicted nucleotidyltransferase AF1967
787 2101 COG1669 R Predicted nucleotidyltransferase MJ0435
340 683 COG1672 R Predicted ATPase, archaeal AAA+ ATPase superfamily
54 72 COG1673 R Predicted RNA-binding protein, contains PUA-like EVE domain
43 46 COG1689 R Class II terpene cyclase family protein AF1543
42 46 COG1707 R Uncharacterized protein, contains ACT and PBP-like DUF5612 domains, MJ1458 family
342 587 COG1708 R Predicted nucleotidyltransferase, MJ0604 family
22 27 COG1710 R Predicted DNA-binding protein MJ1475, contains C-terminal HTH domain
503 530 COG1713 T R Diadenosine tetraphosphatase YqeK or a related HD superfamily phosphohydrolase
306 493 COG1719 R Predicted hydrocarbon binding protein, contains 4VR domain
1628 3909 COG1721 R Uncharacterized membrane-anchored protein with extracellular vWFA and Ig-like domains, component of a predicted archaeal secretion system
516 1074 COG1724 R Predicted RNA binding protein YcfA, dsRBD-like fold, HicA-like mRNA interferase family
275 354 COG1735 R Predicted metal-dependent hydrolase, phosphotriesterase family
1310 1313 COG1739 R Putative translation regulator, IMPACT (imprinted ancient) protein family
1380 2715 COG1741 R Redox-sensitive bicupin YhaK, pirin superfamily
508 558 COG1742 R Uncharacterized inner membrane protein YnfA, drug/metabolite transporter superfamily
81 98 COG1750 R Predicted archaeal serine protease, S18 family
1478 3417 COG1752 R Predicted acylesterase/phospholipase RssA, containd patatin domain
1387 2403 COG1765 R Uncharacterized OsmC-related protein
175 177 COG1768 R Predicted phosphohydrolase, DR1119 family, metallophosphatase superfamily
957 1046 COG1778 M R 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC and related HAD superfamily phosphatases
92 92 COG1779 R C4-type Zn-finger protein
390 449 COG1782 R Predicted metal-dependent RNase, contains metallo-beta-lactamase and KH domains
124 126 COG1784 R TctA family transporter
707 890 COG1785 P R Alkaline phosphatase
13 18 COG1800 R Predicted transglutaminase-like protease, UPF0252 family
942 1302 COG1801 R Sugar isomerase-related protein YecE, UPF0759/DUF72 family
150 212 COG1817 R Predicted glycosyltransferase
133 133 COG1831 R Predicted metal-dependent hydrolase, urease superfamily
1127 1205 COG1832 R Predicted CoA-binding protein
252 254 COG1833 R Uri superfamily endonuclease
326 327 COG1836 R Cytidylyltransferase family enzyme
958 1000 COG1837 R Predicted RNA-binding protein YlqC, contains KH domain, UPF0109 family
913 970 COG1847 R Predicted RNA-binding protein Jag (SpoIIIJ-associated), conains KH and R3H domains
200 219 COG1852 R Predicted redox protein with CxxCxxC motif, DUF116 family
88 98 COG1856 R Uncharacterized conserved protein, radical SAM superfamily
500 830 COG1873 R Sporulation protein YlmC, YlmC/YmxH family, contains PRC-barrel domain
847 882 COG1875 R Predicted ribonuclease YlaK, contains NYN-type RNase and PhoH-family ATPase domains
935 1216 COG1881 R Uncharacterized protein, putative kinase inhibitor, PEBP/RKIP/YbhB/UPF0098 family
896 1152 COG1896 F R 5'-deoxynucleotidase YfbR and related HD superfamily hydrolases
93 104 COG1906 R Predicted GntP-related membrane permease AF0261, DUF401 family
1853 6942 COG1917 R Cupin domain protein related to quercetin dioxygenase
517 626 COG1926 R Predicted phosphoribosyltransferase
148 149 COG1931 R Predicted RNA binding protein with dsRBD fold, UPF0201 family
338 485 COG1938 R Predicted ATP-dependent carboligase, ATP-grasp superfamily
351 388 COG1963 R Acid phosphatase family membrane protein YuiD
155 163 COG1978 R Predicted RNase H-related nuclease YkuK, DUF458 family
599 748 COG1988 R Membrane-bound metal-dependent hydrolase YbcI, DUF457 family
178 283 COG1992 R Predicted transcriptional regulator fused phosphomethylpyrimidine kinase (thiamin biosynthesis)
59 64 COG2000 R Uncharacterized Fe-S cluster-containing protein
6 8 COG2028 R ASCH domain, putative RNA-binding protein, DUF365 family
283 375 COG2044 R Predicted peroxiredoxin, DsrE/DsrF-like family
239 266 COG2047 R Proteasome assembly chaperone (PAC2) family protein
283 292 COG2061 R Uncharacterized conserved protein, contains ACT domain
1446 2982 COG2070 R NAD(P)H-dependent flavin oxidoreductase YrpB, nitropropane dioxygenase family
590 618 COG2078 R Predicted RNA modification protein, AMMECR1 domain
1391 1833 COG2081 R Predicted flavoprotein YhiN
603 986 COG2085 R Predicted dinucleotide-binding enzyme
51 52 COG2100 R Uncharacterized Fe-S cluster-containing enzyme, radical SAM superfamily
124 124 COG2106 R Predicted RNA methylase MTH1, SPOUT superfamily
191 199 COG2118 R DNA-binding TFAR19-related protein, PDSD5 family
612 758 COG2119 R Putative Ca2+/H+ antiporter, TMEM165/GDT1 family
585 806 COG2129 R Predicted phosphoesterase, related to the Icc protein
678 927 COG2130 Q R NADPH-dependent curcumin reductase CurA
1245 8519 COG2141 H R Flavin-dependent oxidoreductase, luciferase family (includes alkanesulfonate monooxygenase SsuD and methylene tetrahydromethanopterin reductase)
164 176 COG2144 R Selenophosphate synthetase-related protein
130 139 COG2150 R Predicted regulator of amino acid metabolism, contains ACT domain
1196 1739 COG2153 R Predicted N-acyltransferase, GNAT family
132 140 COG2158 R Uncharacterized conserved protein, contains a Zn-finger-like domain
94 105 COG2164 R Uncharacterized protein with cyclophilin fold, contains DUF369 domain
119 119 COG2178 R Predicted RNA- or ssDNA-binding protein, translin family
436 450 COG2179 R Predicted phosphohydrolase YqeG, HAD superfamily
421 456 COG2187 R Aminoglycoside phosphotransferase family enzyme
385 546 COG2192 R Predicted carbamoyl transferase, NodU family
68 74 COG2248 R Predicted hydrolase, metallo-beta-lactamase superfamily
850 1502 COG2249 R Putative NADPH-quinone reductase (modulator of drug activity B)
310 350 COG2251 R Predicted nuclease, RecB family
823 1154 COG2261 R Uncharacterized membrane protein YeaQ/YmgE, transglycosylase-associated protein family
246 261 COG2263 R Predicted RNA methylase
669 797 COG2268 R Flotillin family membrane protein YqiK, contains Band7/PHB/SPFH domain
960 1084 COG2270 R MFS-type transporter involved in bile tolerance, Atg22 family
1147 3832 COG2303 I R Choline dehydrogenase or related flavoprotein
607 1004 COG2304 R Secreted protein containing bacterial Ig-like domain and vWFA domain
127 156 COG2306 R Predicted RNA-binding protein, associated with RNAse of E/G family, DUF402 domain
804 1200 COG2308 R Circularly permuted ATP-grasp protein
418 506 COG2314 R Uncharacterized membrane protein YozV, TM2 domain, contains pTyr
368 388 COG2316 R Predicted hydrolase, HD superfamily
731 4172 COG2319 R WD40 repeat
489 627 COG2320 R GrpB domain, predicted nucleotidyltransferase, UPF0157 family
759 944 COG2321 R Predicted metalloprotease
828 1127 COG2331 R Predicted nucleic acid-binding protein, contains Zn-ribbon domain
733 1483 COG2335 R Uncaracterized surface protein containing fasciclin (FAS1) repeats
1060 2014 COG2340 D R Spore germination protein YkwD and related proteins with CAP (CSP/antigen 5/PR1) domain
1099 1551 COG2350 Q R YciI superfamily enzyme, includes 5-CHQ dehydrochlorinase, contains active-site pHis
1123 2458 COG2353 R Polyisoprenoid-binding periplasmic protein YceI
782 1800 COG2358 R TRAP-type uncharacterized transport system, periplasmic component
794 1128 COG2373 R Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family
770 1065 COG2374 R Predicted extracellular nuclease
52 53 COG2380 R NurA-like predicted nuclease, RNAse H fold
790 1071 COG2388 R Predicted acetyltransferase, GNAT superfamily
583 769 COG2391 R Uncharacterized membrane protein YedE/YeeE, contains two sulfur transport domains
69 78 COG2401 R ABC-type ATPase fused to a predicted acetyltransferase domain
226 495 COG2402 R Predicted nucleic acid-binding protein, contains PIN domain
225 452 COG2405 R Predicted nucleic acid-binding protein, contains PIN domain
421 1439 COG2409 R Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily
80 81 COG2410 R Predicted nuclease (RNAse H fold)
85 100 COG2411 R Predicted RNA-binding protein, contains PUA-like ASCH domain
45 47 COG2413 R Predicted nucleotidyltransferase
159 162 COG2433 R Possible nuclease of RNase H fold, RuvC/YqgF family
39 41 COG2441 R Predicted butyrate kinase, DUF1464 family
344 516 COG2445 R Uncharacterized HEPN domain protein YutE, UPF0331/DUF86 family
87 88 COG2454 R Predicted nuclease, contains PIN domain
239 281 COG2461 R Uncharacterized conserved protein AF0170, contains SAB, hemerythrin HHE, and PAS domains
217 232 COG2503 R Predicted secreted acid phosphatase
802 959 COG2509 R FAD-dependent dehydrogenase
209 573 COG2512 R Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain
220 245 COG2516 R Biotin synthase-related protein, radical SAM superfamily
23 24 COG2517 R Predicted RNA-binding protein, contains C-terminal EMAP domain
81 85 COG2521 R Predicted archaeal methyltransferase
242 288 COG2605 R Predicted kinase related to galactokinase and mevalonate kinase
703 715 COG2607 R Predicted ATPase, AAA+ superfamily
454 460 COG2715 R Spore maturation protein SpmA (function unknown)
576 592 COG2718 R Uncharacterized conserved protein YeaH/YhbH, required for sporulation, DUF444 family
566 978 COG2819 R Predicted hydrolase of the alpha/beta superfamily
868 896 COG2824 R Uncharacterized Zn-ribbon-containing protein
37 91 COG2880 R Predicted DNA-binding protein, potential antitoxin AbrB/MazE fold
83 109 COG2881 R GTPase-interacting Yip1 domain
159 308 COG2886 R Predicted antitoxin, contains HTH domain
306 372 COG2888 R Predicted RNA-binding protein involved in translation, contains Zn-ribbon domain, DUF1610 family
574 662 COG2907 R Predicted flavin-containing amine oxidase
662 1010 COG2910 R Putative NADH-flavin reductase
736 1355 COG2936 R Predicted acyl esterase
383 487 COG2940 R SET domain-containing protein (function unknown)
793 904 COG2945 R Alpha/beta superfamily hydrolase
780 795 COG2947 R Predicted RNA-binding protein, contains EVE domain
500 526 COG2954 R CYTH domain, found in class IV adenylate cyclase and various triphosphatases
416 417 COG2959 R Proteobacterial HemX domain, involved in 2-ketogluconate production (unrelated to B. subtilis HemX, COG0755, no evidence of involvement in heme biosynthesis)
874 994 COG2962 R Membrane protein RarD, contains two EamA domains, drug/metabolite transporter family
553 559 COG2983 R Uncharacterized cysteine cluster protein YcgN, CxxCxxCC family
734 1407 COG2984 R ABC-type uncharacterized transport system, periplasmic component
385 536 COG2985 R Uncharacterized membrane protein YbjL, putative transporter
214 257 COG2992 R Uncharacterized FlgJ-related protein
569 572 COG2996 R Predicted RNA-binding protein YitL, contains S1 domains, virulence factor B family
827 989 COG3011 R Predicted thiol-disulfide oxidoreductase YuxK, DCC family
437 476 COG3016 R Putative heme-binding protein PhuW, contains EreA/ChaN-like domain
582 745 COG3021 R Uncharacterized conserved protein YafD, endonuclease/exonuclease/phosphatase (EEP) superfamily
841 845 COG3030 R FxsA protein affecting phage T7 exclusion by the F plasmid, UPF0716 family
150 191 COG3042 R Putative hemolysin
209 212 COG3044 R Predicted ATPase of the ABC class
521 527 COG3046 R Uncharacterized conserved protein related to deoxyribodipyrimidine photolyase
418 578 COG3049 M R Penicillin V acylase or related amidase, Ntn superfamily
100 116 COG3054 R Predicted transcriptional regulator YtfJ
393 408 COG3091 R Predicted Zn-dependent metalloprotease, SprT family
104 104 COG3102 R Uncharacterized conserved protein YecM, predicted metalloenzyme
681 1107 COG3103 R Uncharacterized conserved protein YgiM, contains N-terminal SH3 domain, DUF1202 family
437 557 COG3128 R Predicted 2-oxoglutarate- and Fe(II)-dependent dioxygenase YbiX
683 743 COG3146 R Predicted N-acyltransferase
402 481 COG3150 R Predicted esterase YcpF, UPF0227 family
1344 2755 COG3153 R Predicted N-acetyltransferase YhbS
944 2283 COG3173 R Predicted kinase, aminoglycoside phosphotransferase (APT) family
824 1143 COG3176 R GNAT family N-acetyltransferase domain
742 748 COG3178 R Predicted phosphotransferase, aminoglycoside/choline kinase (APH/ChoK) family
473 618 COG3180 R Uncharacterized membrane protein AbrB, regulator of aidB expression
1033 1468 COG3185 E R 4-hydroxyphenylpyruvate dioxygenase and related hemolysins
48 51 COG3196 R Colicin E2 tolerance protein CbrC, UPF0167 family
150 186 COG3204 R Uncharacterized Ca-binding beta-propeller protein YjiK
717 2583 COG3209 R Uncharacterized conserved protein RhaS, contains 28 RHS repeats
700 971 COG3211 R Secreted phosphatase, PhoX family
368 379 COG3218 R ABC-type uncharacterized transport system, auxiliary component
163 169 COG3223 R Phosphate starvation-inducible membrane PsiE (function unknown)
242 292 COG3224 R Antibiotic biosynthesis monooxygenase (ABM) superfamily enzyme
120 128 COG3233 R Predicted deacetylase
173 173 COG3235 R Uncharacterized CbiM-related membrane protein
673 854 COG3247 R Acid resistance membrane protein HdeD, DUF308 family
172 507 COG3269 R Predicted RNA-binding protein, contains TRAM domain
250 323 COG3273 R Uncharacterized protein, contains PhoU and TrkA_C domains
196 206 COG3294 R Metal-dependent phosphatase/phosphodiesterase, HD supefamily
426 563 COG3296 R Uncharacterized Tic20-related protein, DUF4870 domain
537 724 COG3313 R Predicted Fe-S protein YdhL, DUF1289 family
1109 2937 COG3324 R Lactoylglutathione lyase-related enzyme, vicinal oxygen chelate (VOC) family
229 244 COG3331 R Penicillin-binding protein-related factor A, putative recombinase
457 459 COG3332 R Uncharacterized stress-responsive protein, TANGO2 (Transport and Golgi organisation 2) family, contains NRDE motif
584 1809 COG3333 R TctA family transporter
233 241 COG3341 R Ribonuclease HI-related protein, contains viroplasmin and RNaseH domains
400 492 COG3342 R Uncharacterized conserved protein, Ntn-hydrolase superfamily
414 636 COG3349 R Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster
378 403 COG3359 R Uncharacterized conserved protein YprB, contains RNaseH-like and TPR domains
523 621 COG3360 R Flavin-binding protein dodecin
104 105 COG3364 R Predicted nucleic acid-binding protein, contains Zn-ribbon domain
390 449 COG3367 R Uncharacterized conserved protein, NAD-dependent epimerase/dehydratase family
15 17 COG3368 R Predicted permease
116 150 COG3370 R Uncharacterized conserved protein AF1964, DsrE/DsrF-like family
194 221 COG3372 R Predicted nuclease of restriction endonuclease-like (RecB) superfamily, implicated in nucleotide excision repair
149 179 COG3375 R Predicted acetyltransferase, GNAT superfamily
247 508 COG3379 R Predicted phosphohydrolase or phosphomutase, AlkP superfamily
361 379 COG3380 R Predicted NAD/FAD-dependent oxidoreductase
334 398 COG3382 R B3/B4 domain (DNA/RNA-binding domain of Phe-tRNA-synthetase)
1110 2900 COG3391 R DNA-binding beta-propeller fold protein YncE
664 1128 COG3393 R Predicted acetyltransferase, GNAT family
160 328 COG3397 R Predicted carbohydrate-binding protein, contains CBM5 and CBM33 domains
26 26 COG3400 R Uncharacterized protein AQ_414, contains TrkA and USP-like domains
259 377 COG3401 R Fibronectin type 3 domain
110 1990 COG3413 R Predicted transcriptional regulator, contains HTH domain
375 377 COG3442 R Glutamine amidotransferase related to the GATase domain of CobQ
384 590 COG3450 R Predicted enzyme of the cupin superfamily
433 591 COG3453 R Predicted phosphohydrolase, protein tyrosine phosphatase (PTP) superfamily, DUF442 family
141 146 COG3478 R Predicted nucleic-acid-binding protein, contains Zn-ribbon domain
381 484 COG3488 R Uncharacterized conserved protein with two CxxC motifs, DUF1111 family
314 352 COG3489 R Imelysin-like iron-regulated protein IrpA, duplicated M75 peptidase-like domain
416 499 COG3503 R Integral membrane N-acetyltransferase, HGSNAT/DUF1624 family
326 333 COG3526 R Predicted selenoprotein, Rdx family
186 186 COG3529 R Predicted nucleic-acid-binding protein, contains Zn-ribbon domain
558 621 COG3536 R Putative dioxygenase with GBBH-like_N/DUF971 domain
315 412 COG3541 R Predicted nucleotidyltransferase YcgL
514 532 COG3542 R Predicted sugar epimerase, cupin superfamily
435 573 COG3545 R Predicted esterase of the alpha/beta hydrolase fold
160 170 COG3554 R Spiral beta-roll protein, possibly glycolipid-binding
189 207 COG3560 R Fatty acid repression mutant protein (predicted oxidoreductase)
387 421 COG3565 R Predicted dioxygenase of extradiol dioxygenase family
1321 2572 COG3568 R Metal-dependent hydrolase, endonuclease/exonuclease/phosphatase family
351 361 COG3571 R Predicted hydrolase of the alpha/beta-hydrolase fold
267 318 COG3573 R Predicted oxidoreductase
195 202 COG3575 R Predicted nucleotidyltransferase
628 977 COG3576 R Predicted flavin-nucleotide-binding protein, pyridoxine 5'-phosphate oxidase superfamily
566 809 COG3577 R Predicted aspartyl protease
358 495 COG3580 R Predicted nucleotide-binding protein, sugar kinase/HSP70/actin superfamily
353 493 COG3581 R Predicted nucleotide-binding protein, sugar kinase/HSP70/actin superfamily
412 536 COG3583 R Putative cell wall-binding protein/resuscitation-promoting factor YabE, contains G5 and DUF348 domains
128 135 COG3586 R Uncharacterized protein domain, C-terminal to COG1479 DNAse/DNA nickase
280 375 COG3596 R Predicted GTPase
613 884 COG3607 R Lactoylglutathione lyase-related enzyme, vicinal oxygen chelate (VOC) family
822 1478 COG3608 R Predicted deacylase
630 1230 COG3618 R Predicted metal-dependent hydrolase, TIM-barrel fold
245 317 COG3621 R Patatin-like phospholipase/acyl hydrolase, includes sporulation protein CotR
719 1431 COG3631 R Ketosteroid isomerase-related protein
265 278 COG3683 R ABC-type uncharacterized transport system, periplasmic component
143 347 COG3687 R Predicted metal-dependent hydrolase
340 441 COG3694 R ABC-type uncharacterized transport system, permease component
64 67 COG3700 P R Acid phosphatase, class B
93 142 COG3729 R General stress protein YciG, contains tandem KGG domains
342 388 COG3752 R Steroid 5-alpha reductase family enzyme
305 334 COG3760 R Predicted aminoacyl-tRNA deacylase, YbaK-like aminoacyl-tRNA editing domain
443 656 COG3800 R Predicted transcriptional regulator
355 428 COG3809 R Predicted nucleic acid-binding protein, contains Zn-finger domain
106 116 COG3818 R Predicted N-acetyltransferase, GNAT superfamily
409 1134 COG3828 R Type 1 glutamine amidotransferase (GATase1)-like domain
261 304 COG3864 R Predicted metal-dependent peptidase
617 767 COG3865 R Glyoxalase superfamily enzyme, possible 3-demethylubiquinone-9 3-methyltransferase
68 75 COG3889 R Extracellular solute-binding protein, contains Ig-fold domain
595 2614 COG3899 R Predicted ATPase
262 1282 COG3903 R Predicted ATPase
203 213 COG3907 R Membrane-associated enzyme, PAP2 (acid phosphatase) superfamily
314 355 COG3910 R Predicted ATPase
258 289 COG3911 R Predicted ATPase
399 497 COG3919 R Predicted ATP-dependent carboligase, ATP-grasp superfamily
169 187 COG3930 R Regulator of flavohemoglobin expression, contains QEGLA motif
323 415 COG3945 R Hemerythrin domain
294 444 COG3950 R Predicted ATP-binding protein involved in virulence
219 230 COG3952 R Uncharacterized N-terminal domain of lipid-A-disaccharide synthase
1558 1611 COG3956 R Uncharacterized conserved protein YabN, contains tetrapyrrole methylase and MazG-like pyrophosphatase domain
245 280 COG3961 G H R TPP-dependent 2-oxoacid decarboxylase, includes indolepyruvate decarboxylase
217 284 COG3964 R Predicted amidohydrolase
69 77 COG3969 R Predicted phosphoadenosine phosphosulfate sulfurtransferase, contains C-terminal DUF3440 domain
313 334 COG3970 R Fumarylacetoacetate (FAA) hydrolase family protein
584 805 COG3975 R Predicted metalloprotease, contains C-terminal PDZ domain
302 614 COG3976 R Uncharacterized conserved protein, contains FMN-binding domain
298 375 COG3981 R Predicted acetyltransferase
49 51 COG4002 R Predicted methyltransferase MtxX, methanogen marker protein 4
10 15 COG4007 R Predicted dehydrogenase related to H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase
61 61 COG4012 R Uncharacterized protein, DUF1786 family, actin-like ATPase superfamily
14 14 COG4015 R Predicted dinucleotide-utilizing enzyme of the ThiF/HesA family
34 34 COG4020 R Predicted ATPase/kinase of ASKHA (acetate and sugar kinases, HSC70, actin) superfamily
9 9 COG4025 R Uncharacterized conserved protein MTH423, predicted component of type IV pili-like system, DUF2101 family
16 16 COG4026 R Uncharacterized conserved protein, contains TOPRIM domain, potential nuclease
63 64 COG4028 R Predicted P-loop ATPase/GTPase
34 34 COG4030 R Predicted phosphohydrolase, HAD superfamily
61 77 COG4043 R ASC-1 homology (ASCH) domain, predicted RNA-binding domain
10 10 COG4049 R Uncharacterized conserved protein, contains archaeal-type C2H2 Zn-finger
44 48 COG4052 R Uncharacterized conserved protein related to methyl-CoM reductase subunit C, methanogenesis marker protein 7
34 44 COG4068 R Predicted nucleic acid-binding protein, contains Zn-ribbon domain
46 48 COG4070 R Cyclophilin family protein MJ1412, methanogenesis marker protein 3
24 24 COG4071 R Gamma-glutamyl ligase family protein MJ1361
86 89 COG4076 R Predicted RNA methylase
149 152 COG4087 R Soluble P-type ATPase
371 659 COG4099 R Predicted peptidase
378 386 COG4100 P R Cystathionine beta-lyase family protein involved in aluminum resistance
202 240 COG4101 R Uncharacterized conserved protein, RmlC-like cupin domain
99 99 COG4112 R Predicted phosphoesterase YmaB, NUDIX family
130 131 COG4116 R Predicted triphosphatase or cyclase YjbK, contains CYTH domain
169 179 COG4119 F R Predicted NTP pyrophosphohydrolase, NUDIX family
461 559 COG4120 R ABC-type uncharacterized transport system, permease component
178 190 COG4127 R Predicted restriction endonuclease, Mrr-cat superfamily
56 70 COG4128 R Zona occludens toxin, predicted ATPase
187 195 COG4132 R ABC-type uncharacterized transport system, permease component
299 350 COG4134 R ABC-type uncharacterized transport system YnjBCD, periplasmic component
135 136 COG4135 R ABC-type uncharacterized transport system YnjBCD, permease component
131 131 COG4136 R ABC-type uncharacterized transport system YnjBCD, ATPase component
593 593 COG4137 R ABC-type uncharacterized transport system, permease component
338 617 COG4146 R Uncharacterized membrane permease YidK, sodium:solute symporter family
589 637 COG4152 R ABC-type uncharacterized transport system, ATPase component
101 109 COG4158 R Predicted ABC-type sugar transport system, permease component
339 487 COG4178 R ABC-type uncharacterized transport system, permease and ATPase components
278 331 COG4185 R Predicted ABC-type ATPase or kinase
165 190 COG4186 R Uncharacterized conserved protein MJ1445, calcineurin-like phosphoesterase superfamily
502 875 COG4188 R Predicted dienelactone hydrolase
289 373 COG4226 R Predicted nuclease of the RNAse H fold, HicB family
161 164 COG4240 R Pantothenate kinase-related protein Tda10 (topoisomerase I damage affected protein)
373 562 COG4242 Q R Cyanophycinase and related exopeptidases
386 440 COG4243 R Vitamin K epoxide reductase (VKOR) family protein, predicted involvement in disulfide bond formation
172 221 COG4248 R Uncharacterized conserved protein YegI with protein kinase and helix-hairpin-helix DNA-binding domains
421 1096 COG4249 R Uncharacterized conserved protein, contains caspase domain
402 650 COG4254 R Uncharacterized peptidoglycan binding protein, contains LysM and FecR domains
288 293 COG4258 R Predicted exporter
285 293 COG4261 R Predicted acyltransferase, LPLAT superfamily
360 419 COG4262 R Predicted spermidine synthase with an N-terminal membrane domain
428 577 COG4270 R Membrane protein DoxX, possibly involved in oxidative stress resistance
142 154 COG4271 R Predicted nucleotide-binding protein containing TIR -like domain
506 613 COG4276 R Ligand-binding SRPBCC domain
458 462 COG4277 R Predicted DNA modification or repair protein, contains radical SAM and helix-hairpin-helix domains
174 190 COG4283 R Uncharacterized conserved protein DfsB/IRC4, DUF1706 (PF08020) domain
78 99 COG4285 R Glutamine amidotransferase (GATase1)-like domain
91 98 COG4287 R PhoPQ-activated pathogenicity-related protein
108 114 COG4295 R Predicted RNA repair component, a phosphatase of H2Macro superfamily, DUF2263 family
289 517 COG4299 R Predicted acyltransferase, DUF1624 domain
576 617 COG4301 R Uncharacterized protein, contains predicted SAM-dependent methyltransferase domain
257 339 COG4309 R SirA-like two-layered alpha/beta sandwich domain, DUF2249 family
90 93 COG4310 R Uncharacterized conserved protein, cotains an aminopeptidase-like domain
233 373 COG4312 R Predicted dithiol-disulfide oxidoreductase, DUF899 family
336 480 COG4321 R Predicted DNA-binding protein, contains ribbon-helix-helix (RHH) domain
143 144 COG4324 R Predicted aminopeptidase
109 112 COG4328 R Predicted nuclease (RNAse H fold)
359 432 COG4339 R Predicted metal-dependent phosphohydrolase, HD superfamily
202 218 COG4340 R Predicted dioxygenase, 2-oxoglutarate and Fe-dependent (2OG-Fe) dioxygenase superfamily
217 264 COG4341 R Predicted HD phosphohydrolase
29 30 COG4345 R Predicted DNA binding protein, Pae2254/DUF2258 family
21 21 COG4353 R Acetyltransferase superfamily protein, DUF1122 family
75 80 COG4377 R Predicted metal-dependent membrane protease YhfC, DUF2324 family
307 347 COG4405 R Predicted RNA-binding protein YhfF, contains PUA-like ASCH domain
56 79 COG4449 R Predicted protease, Abi (CAAX) family
290 396 COG4454 R Uncharacterized copper-binding protein, cupredoxin-like subfamily
224 233 COG4469 R Competence protein CoiA, contains predicted nuclease domain
232 234 COG4492 R ACT domain-containing protein, UPF0735 family
364 382 COG4496 R Predicted DNA-binding transcriptional regulator YerC, contains ArsR-like HTH domain
396 547 COG4529 R Uncharacterized NAD(P)/FAD-binding protein YdhS
136 141 COG4551 R Predicted protein tyrosine phosphatase
514 708 COG4552 R Predicted acetyltransferase
343 441 COG4586 R ABC-type uncharacterized transport system, ATPase component
340 444 COG4587 R ABC-type uncharacterized transport system, permease component
389 428 COG4589 R Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase
168 169 COG4590 R ABC-type uncharacterized transport system, permease component
248 310 COG4627 R Predicted SAM-depedendent methyltransferase
195 243 COG4633 R Plastocyanin domain containing protein
216 456 COG4634 R Predicted nuclease, contains PIN domain, potential toxin-antitoxin system component
437 5363 COG4636 R Endonuclease, Uma2 family (restriction endonuclease fold)
511 896 COG4637 R Predicted ATPase
619 1565 COG4638 P R Phenylpropionate dioxygenase or related ring-hydroxylating dioxygenase, large terminal subunit
338 488 COG4639 R Predicted kinase
225 275 COG4645 R Predicted acyltransferase
102 113 COG4655 R Uncharacterized conserved protein, contains TadX/Tad_C domain
556 1220 COG4666 R TRAP-type uncharacterized transport system, fused permease components
259 397 COG4671 R Predicted glycosyl transferase
477 595 COG4674 R ABC-type uncharacterized transport system, ATPase component
154 180 COG4710 R Predicted DNA-binding protein with an HTH domain
11 12 COG4740 R Predicted metalloprotease
107 157 COG4745 R Predicted membrane-bound mannosyltransferase, involved in protein glycosylation
373 475 COG4747 R ACT domain-containing protein
208 213 COG4754 R Extracellular substrate-binding protein
32 46 COG4756 R Predicted cation transporter
257 300 COG4757 R Predicted alpha/beta hydrolase
139 185 COG4759 R Uncharacterized conserved protein, contains thioredoxin-like domain
276 282 COG4764 R Predicted transglycosylase, contains SLT domain
271 404 COG4782 R Esterase/lipase superfamily enzyme
265 285 COG4784 R Putative Zn-dependent protease
55 67 COG4797 R Predicted regulatory domain of a methyltransferase
238 359 COG4798 R Predicted methyltransferase
82 87 COG4801 R Predicted acyltransferase, contains DUF342 domain
334 579 COG4804 R Predicted nuclease of restriction endonuclease-like (RecB) superfamily, DUF1016 family
235 313 COG4821 R Uncharacterized conserved protein, contains SIS (Sugar ISomerase) phosphosugar binding domain
210 212 COG4825 R Uncharacterized conserved protein, contains thiamine pyrophosphokinase N- and C- domains
28 32 COG4827 R Predicted transporter
145 151 COG4848 R YtpQ protein involved in methylglyoxal resistance, DUF1444/UPF0354 family
64 68 COG4849 R Predicted nucleotidyltransferase
136 141 COG4851 R Uncharacterized conserved protein involved in sex pheromone biosynthesis
248 264 COG4866 R N-Acyltransferase, similar to phosphatidylglycerol lysyltransferase
225 229 COG4874 R Amidinotransferase superfamily enzyme, FN0238 family
207 233 COG4880 R Secreted protein containing C-terminal beta-propeller domain distantly related to WD-40 repeats
21 26 COG4882 R Predicted aminopeptidase, Iap family
240 356 COG4889 R Predicted helicase
133 145 COG4892 R Predicted heme/steroid binding protein
37 37 COG4900 R Predicted metallopeptidase
130 150 COG4902 R Ferritin-like protein MJ0754, DUF2202 family
373 721 COG4908 R Uncharacterized conserved protein, contains a NRPS condensation (elongation) domain
31 31 COG4914 R Predicted nucleotidyltransferase
131 141 COG4915 Q R 5-bromo-4-chloroindolyl phosphatase XpaC
71 75 COG4918 R Predicted Fe-S cluster biosynthesis protein YqkB
273 361 COG4922 R Predicted SnoaL-like aldol condensation-catalyzing enzyme
130 141 COG4923 R Predicted nuclease (RNAse H fold)
182 206 COG4925 R Cyclophilin-like family protein
245 301 COG4927 R Predicted choloylglycine hydrolase
278 310 COG4928 R Predicted P-loop ATPase, KAP-like
218 297 COG4938 R Predicted ATPase
174 193 COG4947 R Esterase/lipase superfamily enzyme
1481 5489 COG4948 M R L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily
504 506 COG4956 R Uncharacterized conserved protein YacL, contains PIN and TRAM domains
552 736 COG4976 R Predicted methyltransferase, contains TPR repeat
392 532 COG4980 R Gas vesicle protein YhaH
509 529 COG4989 R Predicted oxidoreductase YdhF
149 255 COG4990 R Predicted cysteine peptidase, C39 family
25 28 COG4996 R Predicted phosphatase
169 178 COG4997 R Predicted house-cleaning noncanonical NTP pyrophosphatase, all-alpha NTP-PPase (MazG) superfamily
29 35 COG5014 R Uncharacterized conserved protein TM0948, MoaA-related, radical SAM superfamily
180 237 COG5015 R Pyridoxamine 5'-phosphate oxidase (PNPOx-like) family protein
2 61 COG5048 R Zn-finger-containing protein
18 18 COG5207 R Uncharacterized Zn-finger protein, UBP-type
78 78 COG5258 R GTPase
406 583 COG5266 R Uncharacterized protein, contains GH25 family domain
16 17 COG5275 R BRCT domain type II
69 76 COG5298 R Predicted metal-dependent carbohydrate esterase YdaL, contains NodB-like catalytic (CE4) domain
283 545 COG5305 R Uncharacterized membrane protein PF0508, contains N-terminal glycosyltransferase domain of PMT family
91 111 COG5306 R Uncharacterized conserved protein MJ1470, contains DUF2341 domain, predicted component of type IV pili-like system
2 2 COG5307 R Guanine-nucleotide exchange factor YEL1, contains Sec7 domain
199 208 COG5322 R Predicted amino acid dehydrogenase
234 450 COG5342 R Invasion protein IalB, involved in pathogenesis
122 147 COG5350 R Predicted protein tyrosine phosphatase
369 394 COG5360 R Uncharacterized conserved protein, heparinase superfamily
59 78 COG5378 R Predicted nucleic acid-binding protein, contains PIN domain
116 122 COG5383 R Uncharacterized metalloenzyme YdcJ, glyoxalase superfamily
95 113 COG5397 R Predicted nucleotidyltransferase superfamily protein
338 510 COG5426 R Uncharacterized protein STM3548, contains class I glutamine amidotransferase domain
111 111 COG5431 R Predicted nucleic acid-binding protein, contains SWIM-type Zn-finger domain
49 70 COG5439 R STAS domain
322 337 COG5465 R Uncharacterized conserved protein YbjN, helps stabilize unstable proteins
309 523 COG5476 R Microcystin degradation protein MlrC, contains DUF1485 domain
478 872 COG5485 R Predicted ester cyclase
295 719 COG5492 R Uncharacterized conserved protein YjdB, contains Ig-like domain
46 111 COG5493 R Uncharacterized protein, contains PD-(D/E)XK nuclease domain
592 595 COG5495 R Predicted oxidoreductase, contains short-chain dehydrogenase (SDR) and DUF2520 domains
350 378 COG5496 R Predicted thioesterase
133 170 COG5504 R Predicted Zn-dependent protease YjaZ, DUF2268 family
327 327 COG5512 R Predicted nucleic acid-binding protein, contains Zn-ribbon domain (includes truncated derivatives)
302 656 COG5516 R Uncharacterized conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding
159 212 COG5519 R Predicted ATPase domain of Cch-like helicases, DUF927 family
22 26 COG5526 R Lysozyme family protein
209 266 COG5553 R Predicted metal-dependent enzyme of the double-stranded beta helix superfamily
198 255 COG5573 R Predicted nucleic acid-binding protein, contains PIN domain
55 66 COG5592 R Hemerythrin domain-containing protein
52 52 COG5595 R Predicted nucleic acid-binding protein, contains Zn-ribbon domain
132 160 COG5610 R Predicted sugar hydrolase, contains GT1 and HAD domains
204 262 COG5611 R Predicted nucleic-acid-binding protein, contains PIN domain
106 138 COG5617 R Predicted membrane glycosyltransferase TK1552, contains 6-pyruvoyl-tetrahydropterin synthase (PTPS)-related domain
291 307 COG5621 R Predicted lipocalin, contains AttH/CrtC domain
106 120 COG5628 R Predicted acetyltransferase
16 25 COG5643 R Uncharacterized conserved protein containing a metal-binding domain
134 155 COG5663 R Uncharacterized conserved protein YqfW, HAD superfamily
67 72 COG5877 R Predicted amidase domain